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J Neurophysiol (June 24, 2009). doi:10.1152/jn.00441.2009
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00441.2009v1
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Submitted on May 21, 2009
Revised on June 19, 2009
Accepted on June 19, 2009

Presynaptic mechanisms of endocannabinoid - mediated long term depression in the hippocampus

Carlos A Lafourcade1*

1 University of Maryland School of Medicine

* To whom correspondence should be addressed. E-mail: clafo001{at}umaryland.edu.

Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid receptors (CB1Rs), and thereby inhibit synaptic transmitter release. The inhibition can be either brief (seconds) or long-lasting (minutes to hours). Recent studies provide insight into the presynaptic mechanisms responsible for long-lasting, eCB-mediated long-term depression (eCB-LTD). Among these, the proteins PKA and RIM1{alpha} appear to be crucial, though other possibilities are emerging.






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