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INVITED REVIEW

Neurobiology of a Simple Memory

¹Neurobehavioral Institute, Department of Zoology, University of Oklahoma, Norman, Oklahoma; and ²Department of Neurobiology and Behavior, Cornell University, Ithaca, New York

Submitted 17 April 2008; accepted in final form 2 May 2008

ABSTRACT

Habituation is one of the simplest forms of memory, yet its neurobiological mechanisms remain largely unknown in mammalian systems. This review summarizes recent multidisciplinary analyses of the neurobiology of mammalian odor habituation including in vitro and in vivo synaptic physiology, sensory physiology, behavioral pharmacology, and computational modeling approaches. The findings show that a metabotropic glutamate receptor–mediated depression of afferent synapses to the olfactory cortex is necessary and perhaps sufficient to account for cortical sensory adaptation and short-term behavioral habituation. Furthermore, long-term habituation is an N-methyl-D-aspartate (NMDA) receptor–dependent process within the olfactory bulb. Thus there is both a pharmacological and anatomical distinction between short-term and long-term memory for habituation. The differential locus of change underlying short- and long-term memory leads to predictable differences in their behavioral characteristics, such as specificity.

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