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J Neurophysiol 100: 1113-1126, 2008. First published June 18, 2008; doi:10.1152/jn.90267.2008
0022-3077/08 $8.00
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Reciprocal Stimulation of Decay Between Serotonergic Facilitation and Depression of Synaptic Transmission

Sun Hee Cho Lee1, Karen Taylor1 and Franklin B. Krasne1,2

1Department of Psychology and 2Brain Research Institute, UCLA, Los Angeles, California

Submitted 28 February 2008; accepted in final form 17 June 2008

Serotonin can produce multiple, contradictory modulatory effects on strength of synaptic transmission in both vertebrate and invertebrate nerve circuits. In crayfish, serotonin (5-HT) can both facilitate and depress transmission to lateral giant escape command neurons; however, which effect is manifest during application, as well as the sign and duration of effects that may continue long after 5-HT washout, may depend on history of application as well as on concentration. We report that protein kinase A (PKA) signaling is essential to the production of facilitation but depression is mediated by non-cAMP/PKA signaling pathways. However, we unexpectedly found that PKA activity is essential for the decay of depression when serotonin is washed out. This, and evidence from the effects of a variety of serotonin application regimens, suggest that facilitatory and depressive states coexist and compete and that the decay of each is dependent on stimulation by the other. A computational model that incorporates these assumptions can account for and rationalize the varied effects of a wide range of serotonin application regimens.

Address for reprint requests and other correspondence: F. Krasne, Dept. of Psychology, UCLA, Los Angeles, CA 90095 (E-mail: krasne{at}psych.ucla.edu)






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