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J Neurophysiol 100: 1147-1151, 2008. First published January 30, 2008; doi:10.1152/jn.01204.2007
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N-Arachidonoyl L-Serine, a Putative Endocannabinoid, Alters the Activation of N-Type Ca2+ Channels in Sympathetic Neurons

Juan Guo, Damian J. Williams and Stephen R. Ikeda

Laboratory of Molecular Physiology; National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health; Bethesda, Maryland

Submitted 29 October 2007; accepted in final form 25 January 2008

The effect of N-arachidonoyl L-serine (ARA-S), a recently discovered lipoamino acid found in the CNS, on N-type Ca2+ channels of rat sympathetic ganglion neurons was determined using whole cell patch clamp. Application of ARA-S produced a rapid and reversible augmentation of Ca2+ current that was voltage dependent and resulted from a hyperpolarizing shift in the activation curve. ARA-S did not influence G protein modulation of Ca2+ channels and appeared to act independently of G-protein-coupled receptors. These findings provide a foundation for investigating possible roles for ARA-S in nervous system function.

Address for reprint requests and other correspondence: S. R. Ikeda, Section on Transmitter Signaling, Laboratory of Molecular Physiology, NIH/NIAAA, 5625 Fishers Ln., MSC 9411, Bethesda, MD 20892-9411 (E-mail: sikeda{at}mail.nih.gov)




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[Abstract] [Full Text] [PDF]


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