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J Neurophysiol 100: 2217-2224, 2008. First published July 23, 2008; doi:10.1152/jn.90411.2008
0022-3077/08 $8.00

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Recovery From Monocular Deprivation Using Binocular Deprivation

¹Department of Science and Technology, Bryant University, Smithfield, Rhode Island; ²Institute for Brain and Neural Systems, Brown University, Providence, Rhode Island; ³Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts; ⁴Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, Texas; and ⁵Department of Physics, Brown University, Providence, Rhode Island; and ⁶Department of Computer Science, University of Massachusetts, Amherst, Massachusetts

Submitted 27 March 2008; accepted in final form 17 July 2008

Ocular dominance (OD) plasticity is a robust paradigm for examining the functional consequences of synaptic plasticity. Previous experimental and theoretical results have shown that OD plasticity can be accounted for by known synaptic plasticity mechanisms, using the assumption that deprivation by lid suture eliminates spatial structure in the deprived channel. Here we show that in the mouse, recovery from monocular lid suture can be obtained by subsequent binocular lid suture but not by dark rearing. This poses a significant challenge to previous theoretical results. We therefore performed simulations with a natural input environment appropriate for mouse visual cortex. In contrast to previous work, we assume that lid suture causes degradation but not elimination of spatial structure, whereas dark rearing produces elimination of spatial structure. We present experimental evidence that supports this assumption, measuring responses through sutured lids in the mouse. The change in assumptions about the input environment is sufficient to account for new experimental observations, while still accounting for previous experimental results.