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This Article Full Text Full Text (PDF) All Versions of this Article: 100/4/2282    most recent 90564.2008v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Greenspan, J. D. Articles by Lenz, F. A. Search for Related Content PubMed PubMed Citation Articles by Greenspan, J. D. Articles by Lenz, F. A.

Cold Stimuli Evoke Potentials That Can Be Recorded Directly From Parasylvian Cortex in Humans

Departments of ¹Neurosurgery and ²Neurology, Johns Hopkins Hospital; ³Program in Neuroscience, Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland; and ⁴Division of Perioperative Care and Emergency Medicine, University Medical Center Utrecht, Utrecht, The Netherlands

Submitted 15 May 2008; accepted in final form 20 June 2008

Anatomic, imaging, and lesion studies suggest that insular or parietal opercular cortical structures mediate the sensation of nonpainful cold. We have now tested the hypothesis that cold stimuli evoke electrical responses from these cortical structures in humans. We recorded the response to cold stimuli from electrodes implanted directly over parasylvian cortex for the investigation of intractable seizures. The results demonstrate that slow potentials can be evoked consistently over structures adjacent to the sylvian fissure in response to nonpainful cold. The polarity of these cold evoked potentials (EPs) for electrodes above the sylvian fissure is opposite to those below. These results suggest that the generator of cold EPs is close to the sylvian fissure in the parietal operculum or insula.