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INNOVATIVE METHODOLOGY

Large-Scale Chronically Implantable Precision Motorized Microdrive Array for Freely Behaving Animals

The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Departments of Brain and Cognitive Sciences, and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts

Submitted 17 June 2008; accepted in final form 23 July 2008

Multiple single-unit recording has become one of the most powerful in vivo electro-physiological techniques for studying neural circuits. The demand has been increasing for small and lightweight chronic recording devices that allow fine adjustments to be made over large numbers of electrodes across multiple brain regions. To achieve this, we developed precision motorized microdrive arrays that use a novel motor multiplexing headstage to dramatically reduce wiring while preserving precision of the microdrive control. Versions of the microdrive array were chronically implanted on both rats (21 microdrives) and mice (7 microdrives), and relatively long-term recordings were taken.