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J Neurophysiol 100: 2977-2980, 2008. First published October 1, 2008; doi:10.1152/jn.91037.2008
0022-3077/08 $8.00
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NEURO FORUM

What Can Population Calcium Imaging Tell Us About Neural Circuits?

Alex C. Kwan

School of Applied and Engineering Physics, Cornell University, Ithaca, New York

ABSTRACT

Calcium imaging of bulk-loaded fluorescent indicators can be used to record the spiking activity of hundreds of neurons. Recent advances promise imaging technologies that are faster, more efficient, and applicable to awake animals, thereby moving imaging capabilities closer to the traditional strengths of multi-electrode arrays. This article reviews these technical achievements and discusses how they can help us achieve the goal of understanding neural circuits.

Address for reprint requests and other correspondence: A. C. Kwan, School of Applied and Engineering Physics, Cornell University, Ithaca NY 14853 (E-mail: cak46{at}cornell.edu)






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