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J Neurophysiol 101: 855-861, 2009. First published December 3, 2008; doi:10.1152/jn.90893.2008
0022-3077/09 $8.00
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Ipsilateral Eye Cortical Maps Are Uniquely Sensitive to Binocular Plasticity

Joshua Faguet, Bruno Maranhao, Spencer L. Smith and Joshua T. Trachtenberg

Department of Neurobiology, The David Geffen School of Medicine, UCLA, Los Angeles, California

Submitted 7 August 2008; accepted in final form 27 November 2008

In the cerebral cortex, neuronal circuits are first laid down by intrinsic mechanisms and then refined by experience. In the canonical model, this refinement is driven by activity-dependent competition between inputs for some limited cortical resource. Here we examine this idea in the mouse visual cortex at the peak of the critical period for experience-dependent plasticity. By imaging intrinsic optical responses, we mapped the strength and size of each eye's cortical representation in normal mice, mice that had been deprived of patterned vision uni- or bilaterally, and in mice in which the contralateral eye had been removed. We find that for both eyes, a period of visual deprivation results in a loss of cortical responsiveness to stimulation through the deprived eye. In addition, the ipsilateral eye pathway is affected by the quality of vision through the opposite eye. Our findings indicate that although both contra- and ipsilateral eye pathways require visual experience for their maintenance, ipsilateral eye projections bear an additional, unique sensitivity to binocular interactions.

Address for reprint requests and other correspondence J. T. Trachtenberg, Dept. of Neurobiology, The David Geffen School of Medicine, UCLA, 635 Charles Young Dr., Los Angeles, CA 90095 (E-mail: jtrachtenberg{at}mednet.ucla.edu)






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