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J Neurophysiol 101: 1690-1694, 2009. First published June 18, 2008; doi:10.1152/jn.90428.2008
0022-3077/09 $8.00
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Interaction Between Finger Opposition Movements and Aftereffects of 1Hz-rTMS on Ipsilateral Motor Cortex

Laura Avanzino1,2, Marco Bove2, Andrea Tacchino2, Carlo Trompetto1, Carla Ogliastro1 and Giovanni Abbruzzese1

1Departments of Neurosciences, Ophthalmology and Genetics and 2Experimental Medicine, Section of Human Physiology, University of Genoa, Italy

Submitted 2 April 2008; accepted in final form 12 June 2008

Abstract

One-hertz repetitive transcranial magnetic stimulation (1Hz-rTMS) over ipsilateral motor cortex is able to modify up to 30 min the motor performance of repetitive finger opposition movements paced with a metronome at 2 Hz. We investigated whether the long-lasting rTMS effect on motor behavior can be modulated by subsequent engagement of the contralateral sensorimotor system. Motor task was performed in different experimental conditions: immediately after rTMS, 30 min after rTMS, or when real rTMS was substituted with sham rTMS. Subjects performing the motor task immediately after rTMS showed modifications in motor behavior ≤30 min after rTMS. On the other hand, when real rTMS was substituted with sham stimulation or when subjects performed the motor task 30 min after the rTMS session, the effect was no longer present. These findings suggest that the combination of ipsilateral 1Hz-rTMS and voluntary movement is crucial to endure the effect of rTMS on the movement itself, probably acting on synaptic plasticity-like mechanism. This finding might provide some useful hints for neurorehabilitation protocols.

Address for reprint requests and other correspondence: G. Abbruzzese, Dept. of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132, Genoa, Italy (E-mail: giabbr{at}unige.it)






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