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Time Course of Attentional Modulation in the Frontal Eye Field During Curve Tracing

¹Department of Vision and Cognition, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences; ²Department of Integrative Neurophysiology, Centre for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, The Netherlands; and ³Department of Physiology, McGill University, Montreal, Quebec, Canada

Submitted 19 September 2008; accepted in final form 23 January 2009

Neurons in the frontal eye fields (FEFs) register incoming visual information and select visual stimuli that are relevant for behavior. Here we investigated the timing of the visual response and the timing of selection by recording from single FEF neurons in a curve-tracing task that requires shifts of attention followed by an oculomotor response. We found that the behavioral selection signal in area FEF had a latency of 147 ms and that it was delayed substantially relative to the visual response, which occurred 50 ms after stimulus presentation. We compared the FEF responses to activity previously recorded in the primary visual cortex (area V1) during the same task. Visual responses in area V1 preceded the FEF responses, but the latencies of selection signals in areas V1 and FEF were similar. The similarity of timing of selection signals in structures at opposite ends of the visual cortical processing hierarchy supports the view that stimulus selection occurs in an interaction between widely separated cortical regions.