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J Neurophysiol 101: 1876-1882, 2009. First published January 28, 2009; doi:10.1152/jn.91002.2008
0022-3077/09 $8.00
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Cortically Activated Interneurons Shape Spatial Aspects of Cortico-Accumbens Processing

Aaron J. Gruber1, Elizabeth M. Powell1,2 and Patricio O'Donnell1,2

1Departments of Anatomy and Neurobiology and 2Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland

Submitted 5 September 2008; accepted in final form 23 January 2009

Basal ganglia circuits are organized as parallel loops that have been proposed to compete in a winner-take-all fashion to determine the appropriate behavioral outcome. However, limited experimental support for strong lateral inhibition mechanisms within striatal regions questions this model. Here, stimulation of the prefrontal cortex (PFC) using naturally occurring bursty patterns inhibited firing in most nucleus accumbens (NA) projection neurons. When an excitatory response was observed for one stimulation site, neighboring PFC sites evoked inhibition in the same neuron. Furthermore, PFC stimulation activated interneurons, and PFC-evoked inhibition was blocked by GABAA antagonists in corticoaccumbens slice preparations. Thus bursting PFC activity recruits local inhibition in the NA, shaping responses of projection neurons with a topographical arrangement that allows inhibition among parallel corticoaccumbens channels. The data indicate a high order of information processing within striatal circuits that should be considered in models of basal ganglia function and disease.

Address for reprint requests and other correspondence: A. J. Gruber, Dept. Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St., Baltimore, MD 21201 (E-mail: agrub001{at}umaryland.edu)






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