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J Neurophysiol 101: 2738-2740, 2009. First published March 25, 2009; doi:10.1152/jn.00141.2009
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NEURO FORUM

Anticipatory Changes in Regional Cerebral Hemodynamics: A New Role for Dopamine?

Can Ozan Tan

Department of Physical Medicine and Rehabilitation, Harvard Medical School, and Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Boston, Massachusetts

ABSTRACT

Recently, adaptively timed, anticipatory changes in hemodynamic responses, independent of neural activity, were described in primate primary visual cortex. Task-related properties of these responses point to a possible link between regional cerebral microcirculation and dopaminergic signaling. In this report, this link is elaborated on the basis of known physiological data and further experiments are proposed to test the possible role of dopamine in task-dependent, "on-demand" allocation of metabolic resources.


Address for reprint requests and other correspondence: C. O. Tan, Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, 125 Nashua Street, Boston, MA 02114 (E-mail: cotan{at}partners.org)







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