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J Neurophysiol 102: 377-386, 2009. First published May 13, 2009; doi:10.1152/jn.90954.2008
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Comparison of Time–Frequency Responses and the Event-Related Potential to Auditory Speech Stimuli in Human Cortex

Erik Edwards1,*, Maryam Soltani1,*, Won Kim1, Sarang S. Dalal2, Srikantan S. Nagarajan2, Mitchel S. Berger3 and Robert T. Knight1

1Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley; and 2Department of Radiology and Biomedical Imaging and 3Department of Neurological Surgery, University of California, San Francisco, California

Submitted 23 August 2008; accepted in final form 10 May 2009

We recorded the electrocorticogram directly from the exposed cortical surface of awake neurosurgical patients during the presentation of auditory syllable stimuli. All patients were unanesthetized as part of a language-mapping procedure for subsequent left-hemisphere tumor resection. Time–frequency analyses showed significant high-gamma ({gamma}high: 70–160 Hz) responses from the left superior temporal gyrus, but no reliable response from the left inferior frontal gyrus. Alpha suppression ({alpha}: 7–14 Hz) and event-related potential responses exhibited a more widespread topography. Across electrodes, the {alpha} suppression from 200 to 450 ms correlated with the preceding (50–200 ms) {gamma}high increase. The results are discussed in terms of the different physiological origins of these electrocortical signals.

Address for reprint requests and other correspondence: E. Edwards, University of Washington, Paul G. Allen Center, Box 352350, Seattle, WA 98195-2350 (E-mail: erik{at}socrates.berkeley.edu)




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