Journal of Neurophysiology, Vol 38, Issue 5 1172-1180, Copyright © 1975 by APS

ARTICLES

Accommodative reactions of medullary respiratory neurons of the cat

D. W. Richter and F. Heyde

In most of the bulbospinal respiratory neurons, threshold depolarization increased during the early period of their spontaneous burst discharge but decreased again at the end of a burst. In some vagal respiratory neurons, however, threshold depolarization increased steadily until the very end of their discharge period. These changes generally were accompanied by changes in the rate of depol1rization of the spikes, the amplitude of their overshoot, and their discharge frequency. For a given synaptic input, as indicated by the constancy of the interspike membrane potential trajectories, threshold depolarization of bulbospinal neurons remained constant or even decreased. Only in some vagal neurons was an increase in threshold deplarization observed under these conditions. With the exception of some vagal neurons, most of the respiratory neurons did not show a pronounced accommodative behavior when stimulated with linear rising currents. When stimulating with current pulses, all neurons discharged repetitively with only slight adaptation, which was already complete by the first few spike intervals. The current-frequency relationship was linear and revealed a primary and secondary range. The results support neither accommodation nor adaptation as important mechanisms in the genesis of the rhythmic activity of respiratory neurons.

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