JN AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 39: 954-969, 1976;
0022-3077/76 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Robinson, D. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Robinson, D. A.

Journal of Neurophysiology, Vol 39, Issue 5 954-969, Copyright © 1976 by APS

ARTICLES

Adaptive gain control of vestibuloocular reflex by the cerebellum

D. A. Robinson

1. The gain of the vestibuloocular reflex (slow-phase eye velocity/head velocity) was measured in 17 adult cats. 2. The gain of the reflex, in the dark, was 0.90 (+/-0.15 SD) over the frequency range 0.03-1.2 Hz. 3. In the range 0.01-0.15 Hz, the phase behaved as though the overall reflex time constant were 12 s or greater. The cupula time constant is 4 s. Therefore, the central part of the reflex must manipulate the canal signal to improve its low-frequency response by a factor of at least three. 4. When the cats wore left-right reversing prisms chronically and were also rotated for 2 h every day, the reflex underwent large, plastic changes. The gain, tested in the dark, decreased by 93% at 0.05 Hz and 55% at 1.2 Hz. In effect, the low-frequency response was abolished. The process took about 8 days. 5. In the light, with reversed vision, the gain decreased further and, at low frequencies, the eye movements did reverse in direction. 6. When the vestibulocerebellum was removed, the gain, in the dark, rose to about 1.17 and the plastic changes caused by reversing prisms were completely abolished. 7. Reversing prisms create vestibuloocular dysmetria. The change in gain they produce is considered to be an adaptive response designed to reduce image motion on the retina during head movements. The vestibulocerebellum is necessary for this adaptive process. It is proposed that detecting and repairing dysmetria (of natural origin) is an important cerebellar function.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
M. Beraneck, J. L. McKee, M. Aleisa, and K. E. Cullen
Asymmetric Recovery in Cerebellar-Deficient Mice Following Unilateral Labyrinthectomy
J Neurophysiol, August 1, 2008; 100(2): 945 - 958.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Xiang, S. B. Yakushin, M. Kunin, T. Raphan, and B. Cohen
Head Stabilization by Vestibulocollic Reflexes During Quadrupedal Locomotion in Monkey
J Neurophysiol, August 1, 2008; 100(2): 763 - 780.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. E. Andreescu, B. A. Milojkovic, E. D. Haasdijk, P. Kramer, F. H. De Jong, A. Krust, C. I. De Zeeuw, and M. T. G. De Jeu
Estradiol Improves Cerebellar Memory Formation by Activating Estrogen Receptor {beta}
J. Neurosci., October 3, 2007; 27(40): 10832 - 10839.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. F. Walker, J. Tian, and D. S. Zee
Kinematics of the Rotational Vestibuloocular Reflex: Role of the Cerebellum
J Neurophysiol, July 1, 2007; 98(1): 295 - 302.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Katoh, J. A. Jindal, and J. L. Raymond
Motor Deficits in Homozygous and Heterozygous P/Q-Type Calcium Channel Mutants
J Neurophysiol, February 1, 2007; 97(2): 1280 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Faulstich, A. M. van Alphen, C. Luo, S. du Lac, and C. I. De Zeeuw
Oculomotor Plasticity During Vestibular Compensation Does Not Depend on Cerebellar LTD
J Neurophysiol, September 1, 2006; 96(3): 1187 - 1195.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Ramachandran and S. G. Lisberger
Transformation of Vestibular Signals Into Motor Commands in the Vestibuloocular Reflex Pathways of Monkeys
J Neurophysiol, September 1, 2006; 96(3): 1061 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Glickstein
Thinking about the cerebellum
Brain, February 1, 2006; 129(2): 288 - 290.
[Full Text] [PDF]

Home page
 Chem SensesHome page
J. Mainland and N. Sobel
The Sniff Is Part of the Olfactory Percept
Chem Senses, February 1, 2006; 31(2): 181 - 196.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. R. Kimpo, E. S. Boyden, A. Katoh, M. C. Ke, and J. L. Raymond
Distinct Patterns of Stimulus Generalization of Increases and Decreases in VOR Gain
J Neurophysiol, November 1, 2005; 94(5): 3092 - 3100.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. F. Walker and D. S. Zee
Cerebellar Disease Alters the Axis of the High-Acceleration Vestibuloocular Reflex
J Neurophysiol, November 1, 2005; 94(5): 3417 - 3429.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. K. Churchland and S. G. Lisberger
Relationship Between Extraretinal Component of Firing Rate and Eye Speed in Area MST of Macaque Monkeys
J Neurophysiol, October 1, 2005; 94(4): 2416 - 2426.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Chaudhuri, B. A. Alseikhan, S. Y. Chang, T. W. Soong, and D. T. Yue
Developmental Activation of Calmodulin-Dependent Facilitation of Cerebellar P-Type Ca2+ Current
J. Neurosci., September 7, 2005; 25(36): 8282 - 8294.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. D. Kassardjian, Y.-F. Tan, J.-Y. J. Chung, R. Heskin, M. J. Peterson, and D. M. Broussard
The Site of a Motor Memory Shifts with Consolidation
J. Neurosci., August 31, 2005; 25(35): 7979 - 7985.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. D. Mainland, B. N. Johnson, R. Khan, R. B. Ivry, and N. Sobel
Olfactory Impairments in Patients with Unilateral Cerebellar Lesions Are Selective to Inputs from the Contralesional Nostril
J. Neurosci., July 6, 2005; 25(27): 6362 - 6371.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Ramachandran and S. G. Lisberger
Normal Performance and Expression of Learning in the Vestibulo-Ocular Reflex (VOR) at High Frequencies
J Neurophysiol, April 1, 2005; 93(4): 2028 - 2038.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
M. R. Cohen, G. W. Meissner, R. J. Schafer, and J. L. Raymond
Reversal of Motor Learning in the Vestibulo-Ocular Reflex in the Absence of Visual Input
Learn. Mem., September 1, 2004; 11(5): 559 - 565.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
S. M. Morton and A. J. Bastian
Cerebellar Control of Balance and Locomotion
Neuroscientist, June 1, 2004; 10(3): 247 - 259.
[Abstract] [PDF]

Home page
 Learn. Mem.Home page
D. M. Broussard and C. D. Kassardjian
Learning in a Simple Motor System
Learn. Mem., March 1, 2004; 11(2): 127 - 136.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
T. Ohyama, W. L. Nores, and M. D. Mauk
Stimulus Generalization of Conditioned Eyelid Responses Produced Without Cerebellar Cortex: Implications for Plasticity in the Cerebellar Nuclei
Learn. Mem., September 1, 2003; 10(5): 346 - 354.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. N. Johnson, J. D. Mainland, and N. Sobel
Rapid Olfactory Processing Implicates Subcortical Control of an Olfactomotor System
J Neurophysiol, August 1, 2003; 90(2): 1084 - 1094.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. Zhou, P. Weldon, B. Tang, and W. M. King
Rapid Motor Learning in the Translational Vestibulo-Ocular Reflex
J. Neurosci., May 15, 2003; 23(10): 4288 - 4298.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
Y.-H. Young, J.-J. Chuu, S.-H. Liu, and S.-Y. Lin-Shiau
Neurotoxic Mechanism of Cinnabar and Mercuric Sulfide on the Vestibulo-Ocular Reflex System of Guinea Pigs
Toxicol. Sci., June 1, 2002; 67(2): 256 - 263.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Yamamoto, Y. Kobayashi, A. Takemura, K. Kawano, and M. Kawato
Computational Studies on Acquisition and Adaptation of Ocular Following Responses Based on Cerebellar Synaptic Plasticity
J Neurophysiol, March 1, 2002; 87(3): 1554 - 1571.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
R. Kono, S. Hasebe, H. Ohtsuki, K. Kashihara, and Y. Shiro
Impaired Vertical Phoria Adaptation in Patients with Cerebellar Dysfunction
Invest. Ophthalmol. Vis. Sci., March 1, 2002; 43(3): 673 - 678.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Rambold, A. Churchland, Y. Selig, L. Jasmin, and S. G. Lisberger
Partial Ablations of the Flocculus and Ventral Paraflocculus in Monkeys Cause Linked Deficits in Smooth Pursuit Eye Movements and Adaptive Modification of the VOR
J Neurophysiol, February 1, 2002; 87(2): 912 - 924.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Ito
Cerebellar Long-Term Depression: Characterization, Signal Transduction, and Functional Roles
Physiol Rev, July 1, 2001; 81(3): 1143 - 1195.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. F. Medina, K. S. Garcia, and M. D. Mauk
A Mechanism for Savings in the Cerebellum
J. Neurosci., June 1, 2001; 21(11): 4081 - 4089.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. L. Babalian and P.-P. Vidal
Floccular Modulation of Vestibuloocular Pathways and Cerebellum-Related Plasticity: An In Vitro Whole Brain Study
J Neurophysiol, November 1, 2000; 84(5): 2514 - 2528.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. F. Medina, K. S. Garcia, W. L. Nores, N. M. Taylor, and M. D. Mauk
Timing Mechanisms in the Cerebellum: Testing Predictions of a Large-Scale Computer Simulation
J. Neurosci., July 15, 2000; 20(14): 5516 - 5525.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. D. Schworm, A. E. Heufelder, A. Kunze, E. Welge, and K.-P. Boergen
Clinical Significance of Saccade Analysis in Early Active Graves' Ophthalmopathy
Invest. Ophthalmol. Vis. Sci., June 1, 2000; 41(7): 1710 - 1718.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
B. T. Crane and J. L. Demer
Effect of Adaptation to Telescopic Spectacles on the Initial Human Horizontal Vestibuloocular Reflex
J Neurophysiol, January 1, 2000; 83(1): 38 - 49.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. S. Garcia, P. M. Steele, and M. D. Mauk
Cerebellar Cortex Lesions Prevent Acquisition of Conditioned Eyelid Responses
J. Neurosci., December 15, 1999; 19(24): 10940 - 10947.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. F. Medina and M. D. Mauk
Simulations of Cerebellar Motor Learning: Computational Analysis of Plasticity at the Mossy Fiber to Deep Nucleus Synapse
J. Neurosci., August 15, 1999; 19(16): 7140 - 7151.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Belton and R. A. McCrea
Contribution of the Cerebellar Flocculus to Gaze Control during Active Head Movements
J Neurophysiol, June 1, 1999; 81(6): 3105 - 3109.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. S. Baizer, I. Kralj-Hans, and M. Glickstein
Cerebellar Lesions and Prism Adaptation in Macaque Monkeys
J Neurophysiol, April 1, 1999; 81(4): 1960 - 1965.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Smith and J. D. Crawford
Neural Control of Rotational Kinematics Within Realistic Vestibuloocular Coordinate Systems
J Neurophysiol, November 1, 1998; 80(5): 2295 - 2315.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Sobel, V. Prabhakaran, C. A. Hartley, J. E. Desmond, Z. Zhao, G. H. Glover, J. D.E. Gabrieli, and E. V. Sullivan
Odorant-Induced and Sniff-Induced Activation in the Cerebellum of the Human
J. Neurosci., November 1, 1998; 18(21): 8990 - 9001.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
X. Lu, O. Hikosaka, and S. Miyachi
Role of Monkey Cerebellar Nuclei in Skill for Sequential Movement
J Neurophysiol, May 1, 1998; 79(5): 2245 - 2254.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J.-J. Wang, Y. Shimansky, V. Bracha, and J. R. Bloedel
Effects of Cerebellar Nuclear Inactivation on the Learning of a Complex Forelimb Movement in Cats
J Neurophysiol, May 1, 1998; 79(5): 2447 - 2459.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. G. McElligott, P. Beeton, and J. Polk
Effect of Cerebellar Inactivation by Lidocaine Microdialysis on the Vestibuloocular Reflex in Goldfish
J Neurophysiol, March 1, 1998; 79(3): 1286 - 1294.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. E. Petersen, H. van Mier, J. A. Fiez, and M. E. Raichle
The effects of practice on the functional anatomy of task performance
PNAS, February 3, 1998; 95(3): 853 - 860.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. A. Scudder, E. Y. Batourina, and G. S. Tunder
Comparison of Two Methods of Producing Adaptation of Saccade Size and Implications for the Site of Plasticity
J Neurophysiol, February 1, 1998; 79(2): 704 - 715.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. E. Angelaki and B. J. M. Hess
Visually Induced Adaptation in Three-Dimensional Organization of Primate Vestibuloocular Reflex
J Neurophysiol, February 1, 1998; 79(2): 791 - 807.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. T. Kenyon
A model of long-term memory storage in the cerebellar cortex: A possible role for plasticity at parallel fiber synapses onto stellate/basket interneurons
PNAS, December 9, 1997; 94(25): 14200 - 14205.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Manor, J. Rinzel, I. Segev, and Y. Yarom
Low-Amplitude Oscillations in the Inferior Olive: A Model Based on Electrical Coupling of Neurons With Heterogeneous Channel Densities
J Neurophysiol, May 1, 1997; 77(5): 2736 - 2752.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. J. Mustari, A. F. Fuchs, and M. Pong
Response Properties of Pretectal Omnidirectional Pause Neurons in the Behaving Primate
J Neurophysiol, January 1, 1997; 77(1): 116 - 125.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
J L Raymond and S G Lisberger
Multiple subclasses of purkinje cells in the primate floccular complex provide similar signals to guide learning in the vestibulo-ocular reflex.
Learn. Mem., January 1, 1997; 3(6): 503 - 518.
[Abstract] [PDF]

Home page
 Learn. Mem.Home page
M D Mauk and N H Donegan
A model of Pavlovian eyelid conditioning based on the synaptic organization of the cerebellum.
Learn. Mem., January 1, 1997; 4(1): 130 - 158.
[Abstract] [PDF]

Home page
 ScienceHome page
S. Lisberger
The neural basis for learning of simple motor skills
Science, November 4, 1988; 242(4879): 728 - 735.
[Abstract] [PDF]

Home page
 ScienceHome page
J. Bloedel
The cerebellum and memory storage
Science, December 18, 1987; 238(4834): 1728 - 1730.
[PDF]

Home page
 ScienceHome page
S. Lisberger
The latency of pathways containing the site of motor learning in the monkey vestibulo-ocular reflex
Science, July 6, 1984; 225(4657): 74 - 76.
[Abstract] [PDF]

Home page
 ScienceHome page
H Collewijn, B. Winterson, and M. Dubois
Optokinetic eye movements in albino rabbits: inversion in anterior visual field
Science, March 24, 1978; 199(4335): 1351 - 1353.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online