Journal of Neurophysiology, Vol 42, Issue 1 166-182, Copyright © 1979 by APS

ARTICLES

Effects of stimulating in raphe nuclei and in reticular formation on response of spinothalamic neurons to mechanical stimuli

D. B. McCreery, J. R. Bloedel and E. G. Hames

1. The purpose of these experiments was to compare effects of electrical stimuli applied in two regions of the brain stem that are the sites of origin of descending bulbospinal systems; namely, the nucleus gigantocellularis of Brodal (7) and the nucleus raphe magnus, on the responses of lumbosacral spinothalamic neurons to mechanical stimuli. 2. In cats anesthetized with alpha-chloralose, stimulating in either of these structures with single pulses of current while the spinothalamic neuron was tonically activated by a sustained mechanical pressure resulted in an increase in the excitability of the cell followed by a prolonged suppression of its impulse activity. 3. For different neurons, the latency of the excitation ranged from 4 to 18 ms following the brain stem stimulus, while the latency of the suppression ranged from 16 to 34 ms. 4. In general, the effects of stimulating in the reticular formation and in the raphe nuclei were similar. although quantitative differences were found in the effects of each on different spinothalamic neurons. On the basis of these two studies, it is argued that the reticulospinal and raphe-spinal systems exert qualitatively similar effects on the responses of spinothalamic neurons evaluated in this experiment. 5. A comparison of the magnitudes of the suppression phase evoked from several different sites in the ipsilateral reticular formation and nucleus raphe magnus suggests that the descending systems arising from both these structures may be quite heterogeneous. 6. Stimulation of both regions of the brain stem produced a much greater suppression of the response of the spinothalamic neurons to slowly changing or sustained mechanical stimuli than to transient stimuli. It is suggested that the effects of descending systems arising both in the raphe nuclei and in the reticular formation on the responses of spinothalamic neurons to a mechanical stimulus are at least as dependent on the time course of the mechanical stimulus as they are on its intensity.

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