JN Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 42: 582-593, 1979;
0022-3077/79 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (193)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wood, J. D.
Right arrow Articles by Mayer, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wood, J. D.
Right arrow Articles by Mayer, C. J.

Journal of Neurophysiology, Vol 42, Issue 2 582-593, Copyright © 1979 by APS

ARTICLES

Serotonergic activation of tonic-type enteric neurons in guinea pig small bowel

J. D. Wood and C. J. Mayer

1. Electrical stimulation of interganglionic fiber tracts of Auerbach's plexus released a chemical substance, which produced a slow EPSP associated with an increase in input resistance in the postsynaptic neuron. 2. This effect of fiber tract stimulation was mimicked by microiontophoretic application of serotonin (5-HT) to the neurons. Both the endogenous transmitter substance and exogenous 5-HT produced membrane depolarization, both increased the input resistance of the neuron, both reduced or abolished hyperpolarizing afterpotentials of the action potentials, and both augmented membrane excitability. 3. During tachyphylaxis to excess 5-HT (1 micron) in the perfusion solution, the response to fiber tract stimulation was also reversibly blocked. 4. Methysergide (30 micron) blocked both the response to fiber tract stimulation and to exogenous 5-HT. 5. Cholinergic agonists and antagonists did not alter the slow EPSP and the response to exogenous 5-HT. 6. The evidence suggests that 5-HT is the neurotransmitter substance that produces the slow EPSP in myenteric neurons.


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
H.-Z. Hu, N. Gao, S. Liu, J. Ren, X. Wang, Y. Xia, and J. D. Wood
Action of Bradykinin in the Submucosal Plexus of Guinea Pig Small Intestine
J. Pharmacol. Exp. Ther., April 1, 2004; 309(1): 320 - 327.
[Abstract] [Full Text]

Home page
 Integr. Comp. Biol.Home page
B. Yu, G. N. Gamkrelidze, P. J. Laurienti, and J. E. Blankenship
Serotonin Directly Increases a Calcium Current in Swim Motoneurons of Aplysia brasiliana
Integr. Comp. Biol., August 1, 2001; 41(4): 1009 - 1025.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. Nicoll
The coupling of neurotransmitter receptors to ion channels in the brain
Science, July 29, 1988; 241(4865): 545 - 551.
[Abstract] [PDF]

Home page
 ScienceHome page
A. Cole and R. Nicoll
Acetylcholine mediates a slow synaptic potential in hippocampal pyramidal cells
Science, September 23, 1983; 221(4617): 1299 - 1301.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online