JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 43: 207-232, 1980;
0022-3077/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mays, L. E.
Right arrow Articles by Sparks, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mays, L. E.
Right arrow Articles by Sparks, D. L.

Journal of Neurophysiology, Vol 43, Issue 1 207-232, Copyright © 1980 by APS

ARTICLES

Dissociation of visual and saccade-related responses in superior colliculus neurons

L. E. Mays and D. L. Sparks

1. Single-unit activity was recorded from the superior colliculus (SC) of monkeys trained to look to visual targets presented on an oscilloscope screen. On one task, target localization required that information concerning the retinal position of the target be combined with information concerning current or future eye position. This task also permitted a dissociation between the site of retinal stimulation and the metrics of the saccade triggered by the stimulation. 2. Vigorous visual responses of superficial SC neurons may occur that do not result in the activation of underlying saccade-related cells. The activity of these neurons signals the occurrence of a visual stimulus, whether or not the stimulus is selected for foveal viewing. 3. Saccade-related (SR) discharges of most intermediate and deep-layer SC neurons precede saccades with particular vectors, regardless of the region of retinal activation initiating the saccade. The discharge of these neurons is tightly coupled to saccade onset, even if changes in eye position have occurred since target appearance. Thus, the discharge of these SR neurons must occur after retinal error and eye-position signals have been combined to compute the necessary saccade vector. For most SR neurons, direct retinal activation of overlying visual neurons had no effect on either the vigor or probability of a SR discharge. The discharge of overlying visual cells is neither necessary nor sufficient to activate most SR cells. 4. The discharge of some SR cells is dependent on prior activation of overlying visual cells. Of 53 SR cells, only 3 were completely dependent on visual stimulation, while another 8 discharged less vigorously if corresponding visual activation failed to occur. 5. About one-quarter of the SR cells showed long-lead preburst activity. This activation was characterized by a low level of firing, which began after the saccade signal and continued until a saccade-linked burst occurred. 6. Cells were isolated that were visually responsive yet discharged prior to saccades in the absence of appropriate retinal stimulation. No component of the discharge of these quasi-visual (QV) cells appeared to be motor in the usual sense. The activity of these neurons appears to reflect eye-position error (the difference between actual and desired eye position) and to hold this information in spatial register until a saccade occurs or is cancelled. 7. It is concluded that the presumed linkage, implied in earlier versions of the foveation hypothesis, between the superficial layers (receiving direct retinal inputs) and the deeper layers of the SC is not necessary for the activation of SR neurons. Results suggest that the SC must generate or receive a signal that combines retinal error and eye-position information. These findings are discussed in terms of current models of the saccadic-control system.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
R. Soetedjo, Y. Kojima, and A. F. Fuchs
Complex Spike Activity in the Oculomotor Vermis of the Cerebellum: A Vectorial Error Signal for Saccade Motor Learning?
J Neurophysiol, October 1, 2008; 100(4): 1949 - 1966.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. P. Mayo and M. A. Sommer
Neuronal Adaptation Caused by Sequential Visual Stimulation in the Frontal Eye Field
J Neurophysiol, October 1, 2008; 100(4): 1923 - 1935.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
B. L. Allman, R. E. Bittencourt-Navarrete, L. P. Keniston, A. E. Medina, M. Y. Wang, and M. A. Meredith
Do Cross-Modal Projections Always Result in Multisensory Integration?
Cereb Cortex, September 1, 2008; 18(9): 2066 - 2076.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. M. Hafed, L. Goffart, and R. J. Krauzlis
Superior Colliculus Inactivation Causes Stable Offsets in Eye Position during Tracking
J. Neurosci., August 6, 2008; 28(32): 8124 - 8137.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Rezvani and B. D. Corneil
Recruitment of a Head-Turning Synergy by Low-Frequency Activity in the Primate Superior Colliculus
J Neurophysiol, July 1, 2008; 100(1): 397 - 411.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. A. Berman, L. M. Heiser, C. A. Dunn, R. C. Saunders, and C. L. Colby
Dynamic Circuitry for Updating Spatial Representations. III. From Neurons to Behavior
J Neurophysiol, July 1, 2007; 98(1): 105 - 121.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. A. Rowland, S. Quessy, T. R. Stanford, and B. E. Stein
Multisensory Integration Shortens Physiological Response Latencies
J. Neurosci., May 30, 2007; 27(22): 5879 - 5884.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. P. Morris, C. D. Chambers, and J. B. Mattingley
Parietal stimulation destabilizes spatial updating across saccadic eye movements
PNAS, May 22, 2007; 104(21): 9069 - 9074.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Hu, H. Jiang, C. Gu, C. Li, and D. L. Sparks
Reliability of oculomotor command signals carried by individual neurons
PNAS, May 8, 2007; 104(19): 8137 - 8142.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
A. T. Herdman and J. D. Ryan
Spatio-temporal Brain Dynamics Underlying Saccade Execution, Suppression, and Error-related Feedback.
J. Cogn. Neurosci., March 1, 2007; 19(3): 420 - 432.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Ratcliff, Y. T. Hasegawa, R. P. Hasegawa, P. L. Smith, and M. A. Segraves
Dual Diffusion Model for Single-Cell Recording Data From the Superior Colliculus in a Brightness-Discrimination Task
J Neurophysiol, February 1, 2007; 97(2): 1756 - 1774.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Murthy, S. Ray, S. M. Shorter, E. G. Priddy, J. D. Schall, and K. G. Thompson
Frontal Eye Field Contributions to Rapid Corrective Saccades
J Neurophysiol, February 1, 2007; 97(2): 1457 - 1469.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. H. Fecteau and D. P. Munoz
Warning Signals Influence Motor Processing
J Neurophysiol, February 1, 2007; 97(2): 1600 - 1609.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Soetedjo and A. F. Fuchs
Complex spike activity of purkinje cells in the oculomotor vermis during behavioral adaptation of monkey saccades.
J. Neurosci., July 19, 2006; 26(29): 7741 - 7755.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. M. Heiser and C. L. Colby
Spatial Updating in Area LIP Is Independent of Saccade Direction
J Neurophysiol, May 1, 2006; 95(5): 2751 - 2767.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Campos, A. Cherian, and M. A. Segraves
Effects of Eye Position upon Activity of Neurons in Macaque Superior Colliculus
J Neurophysiol, January 1, 2006; 95(1): 505 - 526.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
J. H. Fecteau and D. P. Munoz
Correlates of Capture of Attention and Inhibition of Return across Stages of Visual Processing
J. Cogn. Neurosci., November 1, 2005; 17(11): 1714 - 1727.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. A. Berman, L. M. Heiser, R. C. Saunders, and C. L. Colby
Dynamic Circuitry for Updating Spatial Representations. I. Behavioral Evidence for Interhemispheric Transfer in the Split-Brain Macaque
J Neurophysiol, November 1, 2005; 94(5): 3228 - 3248.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
O. A. Mullette-Gillman, Y. E. Cohen, and J. M. Groh
Eye-Centered, Head-Centered, and Complex Coding of Visual and Auditory Targets in the Intraparietal Sulcus
J Neurophysiol, October 1, 2005; 94(4): 2331 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. Bellebaum, I. Daum, B. Koch, M. Schwarz, and K.-P. Hoffmann
The role of the human thalamus in processing corollary discharge
Brain, May 1, 2005; 128(5): 1139 - 1154.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. R. Metzger, O. A. Mullette-Gillman, A. M. Underhill, Y. E. Cohen, and J. M. Groh
Auditory Saccades From Different Eye Positions in the Monkey: Implications for Coordinate Transformations
J Neurophysiol, October 1, 2004; 92(4): 2622 - 2627.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. H. Fecteau, A. H. Bell, and D. P. Munoz
Neural Correlates of the Automatic and Goal-Driven Biases in Orienting Spatial Attention
J Neurophysiol, September 1, 2004; 92(3): 1728 - 1737.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Caspi, B. R. Beutter, and M. P. Eckstein
The time course of visual information accrual guiding eye movement decisions
PNAS, August 31, 2004; 101(35): 13086 - 13090.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. D. Horwitz, A. P. Batista, and W. T. Newsome
Representation of an Abstract Perceptual Decision in Macaque Superior Colliculus
J Neurophysiol, May 1, 2004; 91(5): 2281 - 2296.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. A. Sommer and R. H. Wurtz
What the Brain Stem Tells the Frontal Cortex. II. Role of the SC-MD-FEF Pathway in Corollary Discharge
J Neurophysiol, March 1, 2004; 91(3): 1403 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Tanaka
Contribution of Signals Downstream From Adaptation to Saccade Programming
J Neurophysiol, September 1, 2003; 90(3): 2080 - 2086.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Ratcliff, A. Cherian, and M. Segraves
A Comparison of Macaque Behavior and Superior Colliculus Neuronal Activity to Predictions From Models of Two-Choice Decisions
J Neurophysiol, September 1, 2003; 90(3): 1392 - 1407.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. A. Edelman and M. E. Goldberg
Saccade-Related Activity in the Primate Superior Colliculus Depends on the Presence of Local Landmarks at the Saccade Endpoint
J Neurophysiol, September 1, 2003; 90(3): 1728 - 1736.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. M. G. Walton and L. E. Mays
Discharge of Saccade-Related Superior Colliculus Neurons During Saccades Accompanied by Vergence
J Neurophysiol, August 1, 2003; 90(2): 1124 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. O. Helminski and M. A. Segraves
Macaque Frontal Eye Field Input to Saccade-Related Neurons in the Superior Colliculus
J Neurophysiol, August 1, 2003; 90(2): 1046 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. P. Doubell, I. Skaliora, J. Baron, and A. J. King
Functional Connectivity between the Superficial and Deeper Layers of the Superior Colliculus: An Anatomical Substrate for Sensorimotor Integration
J. Neurosci., July 23, 2003; 23(16): 6596 - 6607.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Kusunoki and M. E. Goldberg
The Time Course of Perisaccadic Receptive Field Shifts in the Lateral Intraparietal Area of the Monkey
J Neurophysiol, March 1, 2003; 89(3): 1519 - 1527.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Terao, N. E. M. Andersson, J. R. Flanagan, and R. S. Johansson
Engagement of Gaze in Capturing Targets for Future Sequential Manual Actions
J Neurophysiol, October 1, 2002; 88(4): 1716 - 1725.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Bergeron and D. Guitton
In Multiple-Step Gaze Shifts: Omnipause (OPNs) and Collicular Fixation Neurons Encode Gaze Position Error; OPNs Gate Saccades
J Neurophysiol, October 1, 2002; 88(4): 1726 - 1742.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. M. McPeek and E. L. Keller
Saccade Target Selection in the Superior Colliculus During a Visual Search Task
J Neurophysiol, October 1, 2002; 88(4): 2019 - 2034.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. A. Sommer and R. H. Wurtz
A Pathway in Primate Brain for Internal Monitoring of Movements
Science, May 24, 2002; 296(5572): 1480 - 1482.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. M. McPeek and E. L. Keller
Superior Colliculus Activity Related to Concurrent Processing of Saccade Goals in a Visual Search Task
J Neurophysiol, April 1, 2002; 87(4): 1805 - 1815.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Nakamura and C. L. Colby
Updating of the visual representation in monkey striate and extrastriate cortex during saccades
PNAS, March 19, 2002; 99(6): 4026 - 4031.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. Takeda and S. Funahashi
Prefrontal Task-Related Activity Representing Visual Cue Location or Saccade Direction in Spatial Working Memory Tasks
J Neurophysiol, January 1, 2002; 87(1): 567 - 588.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. M. Umeno and M. E. Goldberg
Spatial Processing in the Monkey Frontal Eye Field. II. Memory Responses
J Neurophysiol, November 1, 2001; 86(5): 2344 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. D. Horwitz and W. T. Newsome
Target Selection for Saccadic Eye Movements: Direction-Selective Visual Responses in the Superior Colliculus
J Neurophysiol, November 1, 2001; 86(5): 2527 - 2542.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. A. Edelman and M. E. Goldberg
Dependence of Saccade-Related Activity in the Primate Superior Colliculus on Visual Target Presence
J Neurophysiol, August 1, 2001; 86(2): 676 - 691.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Pare and R. H. Wurtz
Progression in Neuronal Processing for Saccadic Eye Movements From Parietal Cortex Area LIP to Superior Colliculus
J Neurophysiol, June 1, 2001; 85(6): 2545 - 2562.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. J. Krauzlis, M. A. Basso, and R. H. Wurtz
Discharge Properties of Neurons in the Rostral Superior Colliculus of the Monkey During Smooth-Pursuit Eye Movements
J Neurophysiol, August 1, 2000; 84(2): 876 - 891.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H.H.L.M. Goossens and A. J. Van Opstal
Blink-Perturbed Saccades in Monkey. II. Superior Colliculus Activity
J Neurophysiol, June 1, 2000; 83(6): 3430 - 3452.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. M. Waitzman, V. L. Silakov, S. DePalma-Bowles, and A. S. Ayers
Effects of Reversible Inactivation of the Primate Mesencephalic Reticular Formation. I. Hypermetric Goal-Directed Saccades
J Neurophysiol, April 1, 2000; 83(4): 2260 - 2284.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Stuphorn, E. Bauswein, and K.-P. Hoffmann
Neurons in the Primate Superior Colliculus Coding for Arm Movements in Gaze-Related Coordinates
J Neurophysiol, March 1, 2000; 83(3): 1283 - 1299.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. D. Corneil and D. P. Munoz
Human Eye-Head Gaze Shifts in a Distractor Task. II. Reduced Threshold for Initiation of Early Head Movements
J Neurophysiol, September 1, 1999; 82(3): 1406 - 1421.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. P. Batista, C. A. Buneo, L. H. Snyder, and R. A. Andersen
Reach Plans in Eye-Centered Coordinates
Science, July 9, 1999; 285(5425): 257 - 260.
[Abstract] [Full Text]

Home page
 ScienceHome page
G. D. Horwitz and W. T. Newsome
Separate Signals for Target Selection and Movement Specification in the Superior Colliculus
Science, May 14, 1999; 284(5417): 1158 - 1161.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
V. Chaturvedi and J. A. M. van Gisbergen
Perturbation of Combined Saccade-Vergence Movements by Microstimulation in Monkey Superior Colliculus
J Neurophysiol, May 1, 1999; 81(5): 2279 - 2296.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Amador, M. Schlag-Rey, and J. Schlag
Primate Antisaccades. I. Behavioral Characteristics
J Neurophysiol, October 1, 1998; 80(4): 1775 - 1786.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. C. Dorris and D. P. Munoz
Saccadic Probability Influences Motor Preparation Signals and Time to Saccadic Initiation
J. Neurosci., September 1, 1998; 18(17): 7015 - 7026.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Aizawa and R. H. Wurtz
Reversible Inactivation of Monkey Superior Colliculus. I. Curvature of Saccadic Trajectory
J Neurophysiol, April 1, 1998; 79(4): 2082 - 2096.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. P. Munoz and P. J. Istvan
Lateral Inhibitory Interactions in the Intermediate Layers of the Monkey Superior Colliculus
J Neurophysiol, March 1, 1998; 79(3): 1193 - 1209.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. H. Lee, M. C. Helms, G. J. Augustine, and W. C. Hall
Role of intrinsic synaptic circuitry in collicular sensorimotor integration
PNAS, November 25, 1997; 94(24): 13299 - 13304.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. M. Umeno and M. E. Goldberg
Spatial Processing in the Monkey Frontal Eye Field. I. Predictive Visual Responses
J Neurophysiol, September 1, 1997; 78(3): 1373 - 1383.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. L. Platt and P. W. Glimcher
Responses of Intraparietal Neurons to Saccadic Targets and Visual Distractors
J Neurophysiol, September 1, 1997; 78(3): 1574 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. Wise and R Desimone
Behavioral neurophysiology: insights into seeing and grasping
Science, November 4, 1988; 242(4879): 736 - 741.
[Abstract] [PDF]

Home page
 ScienceHome page
R. Andersen, G. Essick, and R. Siegel
Encoding of spatial location by posterior parietal neurons
Science, October 25, 1985; 230(4724): 456 - 458.
[Abstract] [PDF]

Home page
 ScienceHome page
L. Mays and D. Sparks
Saccades are spatially, not retinocentrically, coded
Science, June 6, 1980; 208(4448): 1163 - 1165.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online