Journal of Neurophysiology, Vol 49, Issue 6 1303-1318, Copyright © 1983 by APS

ARTICLES

Cross-correlation analysis of geniculostriate neuronal relationships in cats

K. Tanaka

The organization of geniculate inputs to a cat's visual cortical cell was studied by a cross-correlation technique. Simultaneous extracellular recordings were made in the lateral geniculate nucleus and in the striate cortex, and neuronal connectivity between a geniculate cell and a striate cell was examined by cross-correlograms of their impulse discharges under photic stimuli. Of 243 pairs of geniculate and striate cells with overlapping receptive fields, 82 showed positive correlations with short (0.9-2.7 ms) delay times. The delays in 65 of the 82 pairs were short enough to infer that the geniculate cell exerted monosynaptic excitatory action on the striate cell. Monosynaptic excitations were found in all types of striate cells. Those in cells with exclusively an on area or an off area (E-on/off cells) or in simple cells originated mostly from X geniculate cells; those in special-complex cells originated exclusively from Y geniculate cells; and those in standard-complex cells arose from both X and Y geniculate cells. The convergence number from geniculate cells to an E-on/off or simple striate cell was estimated as more than 10, since about 1/10 of the discharges from an E-on/off or simple cell in response to a moving stimulus was correlated with discharges from a geniculate cell. A larger convergence number (more than 30) was obtained for complex cells. Convergence from 2 to 5 geniculate cells was actually demonstrated in 17 of the 32 striate cells, each of which was tested in pair with 3-14 geniculate cells. The converging inputs thus observed included both X and Y geniculate cells in one E-on, one simple, and three standard-complex cells. They included both on-center and off-center geniculate cells in one simple, one special-complex, and five standard-complex cells. Under stimulation with a stationary light slit, the center fields but not the surround fields of geniculate cells were found to contribute to the receptive fields of the simple striate cells. However, the surround fields of geniculate cells contributed to the subliminal response areas flanking the central areas of E-on/off cells. The center fields of the geniculate cells also contributed to the central areas of the E-on/off cells. These observations suggest different models for simple cells and E-on/off cells as regards the organization of their geniculate inputs; simple cells may receive inputs from both on-center and off-center geniculate cells, but E-on/off cells receive inputs only from one or the other of them.

This article has been cited by other articles:

				C. DiMattina and K. Zhang How optimal stimuli for sensory neurons are constrained by network architecture. Neural Comput., March 1, 2008; 20(3): 668 - 708. [Abstract] [Full Text] [PDF]

				S. Haeusler and W. Maass A Statistical Analysis of Information-Processing Properties of Lamina-Specific Cortical Microcircuit Models Cereb Cortex, January 1, 2007; 17(1): 149 - 162. [Abstract] [Full Text] [PDF]

				C. Bardy, J. Y. Huang, C. Wang, T. FitzGibbon, and B. Dreher 'Simplification' of responses of complex cells in cat striate cortex: suppressive surrounds and 'feedback' inactivation J. Physiol., August 1, 2006; 574(3): 731 - 750. [Abstract] [Full Text] [PDF]

				A. F. Teich and N. Qian Comparison Among Some Models of Orientation Selectivity J Neurophysiol, July 1, 2006; 96(1): 404 - 419. [Abstract] [Full Text] [PDF]

				F. J Veredas, F. J Vico, and J.-M. Alonso Factors determining the precision of the correlated firing generated by a monosynaptic connection in the cat visual pathway J. Physiol., September 15, 2005; 567(3): 1057 - 1078. [Abstract] [Full Text] [PDF]

				J.-M. Alonso and H. A. Swadlow Thalamocortical Specificity and the Synthesis of Sensory Cortical Receptive Fields J Neurophysiol, July 1, 2005; 94(1): 26 - 32. [Abstract] [Full Text] [PDF]

				M. D. Menz and R. D. Freeman Functional Connectivity of Disparity-Tuned Neurons in the Visual Cortex J Neurophysiol, April 1, 2004; 91(4): 1794 - 1807. [Abstract] [Full Text] [PDF]

				T. Z. Lauritzen and K. D. Miller Different Roles for Simple-Cell and Complex-Cell Inhibition in V1 J. Neurosci., November 12, 2003; 23(32): 10201 - 10213. [Abstract] [Full Text] [PDF]

				L. M. Martinez and J.-M. Alonso Complex Receptive Fields in Primary Visual Cortex Neuroscientist, October 1, 2003; 9(5): 317 - 331. [Abstract] [PDF]

				P. Kara and R. C. Reid Efficacy of Retinal Spikes in Driving Cortical Responses J. Neurosci., September 17, 2003; 23(24): 8547 - 8557. [Abstract] [Full Text] [PDF]

				C.-I Yeh, C. R. Stoelzel, and J.-M. Alonso Two Different Types of Y Cells in the Cat Lateral Geniculate Nucleus J Neurophysiol, September 1, 2003; 90(3): 1852 - 1864. [Abstract] [Full Text] [PDF]

				M. S. Livingstone and B. R. Conway Substructure of Direction-Selective Receptive Fields in Macaque V1 J Neurophysiol, May 1, 2003; 89(5): 2743 - 2759. [Abstract] [Full Text] [PDF]

				W. M. Usrey, M. P. Sceniak, and B. Chapman Receptive Fields and Response Properties of Neurons in Layer 4 of Ferret Visual Cortex J Neurophysiol, February 1, 2003; 89(2): 1003 - 1015. [Abstract] [Full Text] [PDF]

				J. A. Hirsch Synaptic Physiology and Receptive Field Structure in the Early Visual Pathway of the Cat Cereb Cortex, January 1, 2003; 13(1): 63 - 69. [Abstract] [Full Text] [PDF]

				K. D. Miller Understanding Layer 4 of the Cortical Circuit: A Model Based on Cat V1 Cereb Cortex, January 1, 2003; 13(1): 73 - 82. [Abstract] [Full Text] [PDF]

				P. Reinagel and R. C. Reid Precise Firing Events Are Conserved across Neurons J. Neurosci., August 15, 2002; 22(16): 6837 - 6841. [Abstract] [Full Text] [PDF]

				L. M. Miller, M. A. Escabi, H. L. Read, and C. E. Schreiner Spectrotemporal Receptive Fields in the Lemniscal Auditory Thalamus and Cortex J Neurophysiol, January 1, 2002; 87(1): 516 - 527. [Abstract] [Full Text] [PDF]

				L. M. Miller, M. A. Escabi, and C. E. Schreiner Feature Selectivity and Interneuronal Cooperation in the Thalamocortical System J. Neurosci., October 15, 2001; 21(20): 8136 - 8144. [Abstract] [Full Text] [PDF]

				T. Z. Lauritzen, A. E. Krukowski, and K. D. Miller Local Correlation-Based Circuitry Can Account for Responses to Multi-Grating Stimuli in a Model of Cat V1 J Neurophysiol, October 1, 2001; 86(4): 1803 - 1815. [Abstract] [Full Text] [PDF]

				K. Suder, F. Wörgötter, and T. Wennekers Neural Field Model of Receptive Field Restructuring in Primary Visual Cortex Neural Comput., January 1, 2001; 13(1): 139 - 159. [Abstract] [Full Text]

				W. M. Usrey, J.-M. Alonso, and R. C. Reid Synaptic Interactions between Thalamic Inputs to Simple Cells in Cat Visual Cortex J. Neurosci., July 15, 2000; 20(14): 5461 - 5467. [Abstract] [Full Text] [PDF]

				S. Funahashi and M. Inoue Neuronal Interactions Related to Working Memory Processes in the Primate Prefrontal Cortex Revealed by Cross-correlation Analysis Cereb Cortex, June 1, 2000; 10(6): 535 - 551. [Abstract] [Full Text] [PDF]

				H. A. Swadlow and A. G. Gusev The Influence of Single VB Thalamocortical Impulses on Barrel Columns of Rabbit Somatosensory Cortex J Neurophysiol, May 1, 2000; 83(5): 2802 - 2813. [Abstract] [Full Text] [PDF]

				B. Chapman and I. Godecke Cortical Cell Orientation Selectivity Fails to Develop in the Absence of ON-Center Retinal Ganglion Cell Activity J. Neurosci., March 1, 2000; 20(5): 1922 - 1930. [Abstract] [Full Text] [PDF]

				A. L. Humphrey, A. B. Saul, and J. C. Feidler Strobe Rearing Prevents the Convergence of Inputs With Different Response Timings Onto Area 17 Simple Cells J Neurophysiol, December 1, 1998; 80(6): 3005 - 3020. [Abstract] [Full Text] [PDF]

				E. Erwin and K. D. Miller Correlation-Based Development of Ocularly Matched Orientation and Ocular Dominance Maps: Determination of Required Input Activities J. Neurosci., December 1, 1998; 18(23): 9870 - 9895. [Abstract] [Full Text] [PDF]

				J. A. Hirsch, J.-M. Alonso, R. C. Reid, and L. M. Martinez Synaptic Integration in Striate Cortical Simple Cells J. Neurosci., November 15, 1998; 18(22): 9517 - 9528. [Abstract] [Full Text] [PDF]

				M. Castelo-Branco, S. Neuenschwander, and W. Singer Synchronization of Visual Responses between the Cortex, Lateral Geniculate Nucleus, and Retina in the Anesthetized Cat J. Neurosci., August 15, 1998; 18(16): 6395 - 6410. [Abstract] [Full Text] [PDF]

				T. W. Troyer, A. E. Krukowski, N. J. Priebe, and K. D. Miller Contrast-Invariant Orientation Tuning in Cat Visual Cortex: Thalamocortical Input Tuning and Correlation-Based Intracortical Connectivity J. Neurosci., August 1, 1998; 18(15): 5908 - 5927. [Abstract] [Full Text] [PDF]

				M. N. Shadlen and W. T. Newsome The Variable Discharge of Cortical Neurons: Implications for Connectivity, Computation, and Information Coding J. Neurosci., May 15, 1998; 18(10): 3870 - 3896. [Abstract] [Full Text] [PDF]

				H. A. Swadlow, I. N. Beloozerova, and M. G. Sirota Sharp, Local Synchrony Among Putative Feed-Forward Inhibitory Interneurons of Rabbit Somatosensory Cortex J Neurophysiol, February 1, 1998; 79(2): 567 - 582. [Abstract] [Full Text] [PDF]

				I. Ohzawa, G. C. Deangelis, and R. D. Freeman Encoding of Binocular Disparity by Complex Cells in the Cat's Visual Cortex J Neurophysiol, June 1, 1997; 77(6): 2879 - 2909. [Abstract] [Full Text] [PDF]

				R. K. Carder Immunocytochemical Characterization of AMPA-Selective Glutamate Receptor Subunits: Laminar and Compartmental Distribution in Macaque Striate Cortex J. Neurosci., May 1, 1997; 17(9): 3352 - 3363. [Abstract] [Full Text] [PDF]

				E. S. Ruthazer and M. P. Stryker The Role of Activity in the Development of Long-Range Horizontal Connections in Area 17 of the Ferret J. Neurosci., November 15, 1996; 16(22): 7253 - 7269. [Abstract] [Full Text] [PDF]