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J Neurophysiol 51: 361-374, 1984;
0022-3077/84 $5.00
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Journal of Neurophysiology, Vol 51, Issue 2 361-374, Copyright © 1984 by APS

ARTICLES

Effects of 5-hydroxytryptamine on membrane potential, contractility, accumulation of cyclic AMP, and Ca2+ movements in anterior aorta and ventricle of Aplysia

M. Sawada, M. Ichinose, I. Ito, T. Maeno and D. J. McAdoo

Effects of 5-hydroxytryptamine (serotonin; 5-HT) on the anterior aorta and ventricle muscle of the marine gastropod Aplysia are characterized. Bath-applied 5-HT depolarizes muscle fibers and causes tension increases in both the anterior aorta and ventricle above ca. 10(-9) M. Iontophoretically applied 5-HT caused localized depolarizations of anterior aorta muscle fibers. 5-HT increases the levels of adenosine-3',5'-cyclic monophosphate (cAMP) markedly in the anterior aorta of A. kurodai and A. californica and in the ventricle of A. kurodai. Effects of 5-HT on the contractility of and cAMP synthesis in the anterior aorta and ventricle are both blocked by methysergide. 5-HT and cAMP analogs stimulate 45Ca2+ efflux from the ventricle, implying that the effects of cAMP on contractility involve intracellular Ca2+ movements.


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