JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 51: 1196-1219, 1984;
0022-3077/84 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Deschenes, M.
Right arrow Articles by Steriade, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Deschenes, M.
Right arrow Articles by Steriade, M.

Journal of Neurophysiology, Vol 51, Issue 6 1196-1219, Copyright © 1984 by APS

ARTICLES

Electrophysiology of neurons of lateral thalamic nuclei in cat: resting properties and burst discharges

M. Deschenes, M. Paradis, J. P. Roy and M. Steriade

Intracellular and extracellular recordings were performed in lateral thalamic nuclei (ventroanterior-ventrolateral, ventroposterolateral, centralis, lateralis, and reticularis) of cats under barbiturate anesthesia. Neurons were driven antidromically and/or synaptically by stimulating cortical projection areas and prethalamic afferent pathways. Three neuronal populations were identified on the basis of electrophysiological and anatomical criteria: thalamic relay neurons, local interneurons, and reticularis thalami neurons. At rest, two coexistent rhythms were observed in thalamic neurons. Brief episodes (1-2 s) of membrane-potential oscillations at frequencies of 8-12 Hz appeared with a periodicity of about 10 s. In relay neurons, each episode was characterized by a sequence of hyperpolarizations and burst discharges. These rhythmic episodes of hyperpolarization recurring about every 10 s could be reversed in sign by hyperpolarizing currents or by Cl injection, hence suggesting that they were mainly composed of rhythmic inhibitory postsynaptic potentials (IPSPs). This result also indicated that the slow 0.1-Hz rhythm was imposed on relay neurons by other neuronal pools. Following a complete isolation of the thalamus by cortical and high brain stem lesions, the slow 0.1-Hz rhythm was still present, and it was concluded that this rhythm was generated within the thalamus by inhibitory elements. In thalamic interneurons (identified by electrophysiological criteria) brief episodes (1-2 s) of repetitive depolarizations (8-12 Hz) and burst discharges recurred every 10 s. In the interval, the membrane potential of interneurons slowly hyperpolarized, contrasting with the rhythmic phasic hyperpolarizations observed in relay neurons. Electrophysiological properties shared by most relay neurons included a) afterspike hyperpolarizing potentials of long duration, which were blocked by injections of a Ca chelator; b) a pacemaker potential in the vicinity of the spike trigger level; and c) a low-threshold somatic Ca conductance that underlies burst discharges. As a general rule, prethalamic volleys induced faster rising and shorter lasting EPSPs than cortical volleys. Moreover prethalamic afferent-evoked responses could be associated with production of fast prepotentials, some of which appeared to result from dendritic spiking. It appears that synaptic and intrinsic membrane properties of thalamic neurons allow them to function under two modes: a relay mode and an oscillatory mode; the oscillatory mode being intrinsic to the thalamus and the relay mode being commanded and maintained by cortical and brain stem structures.


This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
P Plaha, S Filipovic, and S S Gill
Induction of parkinsonian resting tremor by stimulation of the caudal zona incerta nucleus: a clinical study
J. Neurol. Neurosurg. Psychiatry, May 1, 2008; 79(5): 514 - 521.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. G. Jones
Calcium channels in higher-level brain function
PNAS, November 13, 2007; 104(46): 17903 - 17904.
[Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
U. Kim and L.-y. Chung
Dual GABAergic Synaptic Response of Fast Excitation and Slow Inhibition in the Medial Habenula of Rat Epithalamus
J Neurophysiol, September 1, 2007; 98(3): 1323 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Augustinaite and P. Heggelund
Changes in firing pattern of lateral geniculate neurons caused by membrane potential dependent modulation of retinal input through NMDA receptors
J. Physiol., July 1, 2007; 582(1): 297 - 315.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. Pinault, A. Slezia, and L. Acsady
Corticothalamic 5-9 Hz oscillations are more pro-epileptogenic than sleep spindles in rats
J. Physiol., July 1, 2006; 574(1): 209 - 227.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. R. Llinas and M. Steriade
Bursting of Thalamic Neurons and States of Vigilance
J Neurophysiol, June 1, 2006; 95(6): 3297 - 3308.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. L. Molineux, J. E. McRory, B. E. McKay, J. Hamid, W. H. Mehaffey, R. Rehak, T. P. Snutch, G. W. Zamponi, and R. W. Turner
Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons
PNAS, April 4, 2006; 103(14): 5555 - 5560.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J.-I. Lee, S. Ohara, P. M. Dougherty, and F. A. Lenz
Pain and Temperature Encoding in the Human Thalamic Somatic Sensory Nucleus (Ventral caudal): Inhibition-Related Bursting Evoked by Somatic Stimuli
J Neurophysiol, September 1, 2005; 94(3): 1676 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. D. Traub, D. Contreras, M. O. Cunningham, H. Murray, F. E. N. LeBeau, A. Roopun, A. Bibbig, W. B. Wilent, M. J. Higley, and M. A. Whittington
Single-Column Thalamocortical Network Model Exhibiting Gamma Oscillations, Sleep Spindles, and Epileptogenic Bursts
J Neurophysiol, April 1, 2005; 93(4): 2194 - 2232.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Broberger and D. A. McCormick
Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus
J. Neurosci., February 16, 2005; 25(7): 1664 - 1673.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y.-Q. Yu, Y. Xiong, Y.-S. Chan, and J. He
In vivo intracellular responses of the medial geniculate neurones to acoustic stimuli in anaesthetized guinea pigs
J. Physiol., October 1, 2004; 560(1): 191 - 205.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Anderson, B. Hu, Q. Pittman, and Z. H. T. Kiss
Mechanisms of deep brain stimulation: an intracellular study in rat thalamus
J. Physiol., August 15, 2004; 559(1): 301 - 313.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Leresche, J. Hering, and R. C. Lambert
Paradoxical Potentiation of Neuronal T-Type Ca2+ Current by ATP at Resting Membrane Potential
J. Neurosci., June 16, 2004; 24(24): 5592 - 5602.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Li, M. E. Bickford, and W. Guido
Distinct Firing Properties of Higher Order Thalamic Relay Neurons
J Neurophysiol, July 1, 2003; 90(1): 291 - 299.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. J. Staba, B. Brett-Green, M. Paulsen, and D. S. Barth
Effects of Ventrobasal Lesion and Cortical Cooling on Fast Oscillations (>200 Hz) in Rat Somatosensory Cortex
J Neurophysiol, May 1, 2003; 89(5): 2380 - 2388.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Cotillon-Williams and J.-M. Edeline
Evoked Oscillations in the Thalamo-Cortical Auditory System Are Present in Anesthetized but not in Unanesthetized Rats
J Neurophysiol, April 1, 2003; 89(4): 1968 - 1984.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
E. Perez-Reyes
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
Physiol Rev, January 1, 2003; 83(1): 117 - 161.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. W. Crabtree and J. T. R. Isaac
New Intrathalamic Pathways Allowing Modality-Related and Cross-Modality Switching in the Dorsal Thalamus
J. Neurosci., October 1, 2002; 22(19): 8754 - 8761.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Bayer, E. Eggermann, B. Saint-Mleux, D. Machard, B. E. Jones, M. Muhlethaler, and M. Serafin
Selective Action of Orexin (Hypocretin) on Nonspecific Thalamocortical Projection Neurons
J. Neurosci., September 15, 2002; 22(18): 7835 - 7839.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. E. Fanselow, K. Sameshima, L. A. Baccala, and M. A. L. Nicolelis
Thalamic bursting in rats during different awake behavioral states
PNAS, December 18, 2001; 98(26): 15330 - 15335.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. R. McQuiston and L. C. Katz
Electrophysiology of Interneurons in the Glomerular Layer of the Rat Olfactory Bulb
J Neurophysiol, October 1, 2001; 86(4): 1899 - 1907.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Steriade
Impact of Network Activities on Neuronal Properties in Corticothalamic Systems
J Neurophysiol, July 1, 2001; 86(1): 1 - 39.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. J. Zhu and P. Heggelund
Muscarinic Regulation of Dendritic and Axonal Outputs of Rat Thalamic Interneurons: A New Cellular Mechanism for Uncoupling Distal Dendrites
J. Neurosci., February 15, 2001; 21(4): 1148 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Gutierrez, C. L. Cox, J. Rinzel, and S. M. Sherman
Dynamics of Low-Threshold Spike Activation in Relay Neurons of the Cat Lateral Geniculate Nucleus
J. Neurosci., February 1, 2001; 21(3): 1022 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. J. Ramcharan, C. L. Cox, X. J. Zhan, S. M. Sherman, and J. W. Gnadt
Cellular Mechanisms Underlying Activity Patterns in the Monkey Thalamus During Visual Behavior
J Neurophysiol, October 1, 2000; 84(4): 1982 - 1987.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Bazhenov, I. Timofeev, M. Steriade, and T. Sejnowski
Spiking-Bursting Activity in the Thalamic Reticular Nucleus Initiates Sequences of Spindle Oscillations in Thalamic Networks
J Neurophysiol, August 1, 2000; 84(2): 1076 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. J. Zhu and F.-S. Lo
Three GABA Receptor-Mediated Postsynaptic Potentials in Interneurons in the Rat Lateral Geniculate Nucleus
J. Neurosci., July 15, 1999; 19(14): 5721 - 5730.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. J. Zhu and B. W. Connors
Intrinsic Firing Patterns and Whisker-Evoked Synaptic Responses of Neurons in the Rat Barrel Cortex
J Neurophysiol, March 1, 1999; 81(3): 1171 - 1183.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. J. Zhu, W. W. Lytton, J.-T. Xue, and D. J. Uhlrich
An Intrinsic Oscillation in Interneurons of the Rat Lateral Geniculate Nucleus
J Neurophysiol, February 1, 1999; 81(2): 702 - 711.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Lavin and A. A. Grace
Dopamine Modulates the Responsivity of Mediodorsal Thalamic Cells Recorded In Vitro
J. Neurosci., December 15, 1998; 18(24): 10566 - 10578.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Grenier, I. Timofeev, and M. Steriade
Leading role of thalamic over cortical neurons during postinhibitory rebound excitation
PNAS, November 10, 1998; 95(23): 13929 - 13934.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. V. Frantseva, J. L. P. Velazquez, and P. L. Carlen
Changes in Membrane and Synaptic Properties of Thalamocortical Circuitry Caused by Hydrogen Peroxide
J Neurophysiol, September 1, 1998; 80(3): 1317 - 1326.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Steriade, I. Timofeev, F. Grenier, and N. Durmuller
Role of Thalamic and Cortical Neurons in Augmenting Responses and Self-Sustained Activity: Dual Intracellular Recordings In Vivo
J. Neurosci., August 15, 1998; 18(16): 6425 - 6443.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Leresche, H. R. Parri, G. Erdemli, A. Guyon, J. P. Turner, S. R. Williams, E. Asprodini, and V. Crunelli
On the Action of the Anti-Absence Drug Ethosuximide in the Rat and Cat Thalamus
J. Neurosci., July 1, 1998; 18(13): 4842 - 4853.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Timofeev and M. Steriade
Cellular Mechanisms Underlying Intrathalamic Augmenting Responses of Reticular and Relay Neurons
J Neurophysiol, May 1, 1998; 79(5): 2716 - 2729.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. V. Sanchez-Vives and D. A. McCormick
Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro
J. Neurosci., November 15, 1997; 17(22): 8880 - 8893.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Contreras, N. Durmuller, and M. Steriade
Absence of a Prevalent Laminar Distribution of IPSPs in Association Cortical Neurons of Cat
J Neurophysiol, November 1, 1997; 78(5): 2742 - 2753.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Bhattacharjee, R. M. Whitehurst Jr., M. Zhang, L. Wang, and M. Li
T-Type Calcium Channels Facilitate Insulin Secretion by Enhancing General Excitability in the Insulin-Secreting {beta}-Cell Line, INS-1
Endocrinology, September 1, 1997; 138(9): 3735 - 3740.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. L. Cox, J. R. Huguenard, and D. A. Prince
Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus
PNAS, August 5, 1997; 94(16): 8854 - 8859.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Pirchio, J. P. Turner, S. R. Williams, E. Asprodini, and V. Crunelli
Postnatal Development of Membrane Properties and delta  Oscillations in Thalamocortical Neurons of the Cat Dorsal Lateral Geniculate Nucleus
J. Neurosci., July 15, 1997; 17(14): 5428 - 5444.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Steriade and I. Timofeev
Short-Term Plasticity during Intrathalamic Augmenting Responses in Decorticated Cats
J. Neurosci., May 15, 1997; 17(10): 3778 - 3795.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Q. Zhou, D. W. Godwin, D. M. O'Malley, and P. R. Adams
Visualization of Calcium Influx Through Channels That Shape the Burst and Tonic Firing Modes of Thalamic Relay Cells
J Neurophysiol, May 1, 1997; 77(5): 2816 - 2825.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. M. Dougherty, Y. J. Li, F. A. Lenz, L. Rowland, and S. Mittman
Correlation of Effects of General Anesthetics on Somatosensory Neurons in the Primate Thalamus and Cortical EEG Power
J Neurophysiol, March 1, 1997; 77(3): 1375 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. L. Cox, J. R. Huguenard, and D. A. Prince
Peptidergic Modulation of Intrathalamic Circuit Activity In Vitro: Actions of Cholecystokinin
J. Neurosci., January 1, 1997; 17(1): 70 - 82.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. Castro-Alamancos and B. W. Connors
Cellular Mechanisms of the Augmenting Response: Short-Term Plasticity in a Thalamocortical Pathway
J. Neurosci., December 1, 1996; 16(23): 7742 - 7756.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. Hosford, S Clark, Z Cao, W. Wilson Jr, F. Lin, R. Morrisett, and A Huin
The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice
Science, July 17, 1992; 257(5068): 398 - 401.
[Abstract] [PDF]

Home page
 ScienceHome page
R. Traub, R Miles, and R. Wong
Model of the origin of rhythmic population oscillations in the hippocampal slice
Science, March 10, 1989; 243(4896): 1319 - 1325.
[Abstract] [PDF]

Home page
 ScienceHome page
R. Llinas
The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function
Science, December 23, 1988; 242(4886): 1654 - 1664.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online