| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 56, Issue 2 507-522, Copyright © 1986 by APS
ARTICLES |
S. M. Thompson and D. A. Prince
Intracellular recordings were obtained from guinea pig hippocampal CA1 pyramidal neurons maintained in vitro. Focal applications of glutamate produced depolarizations followed by prolonged hyperpolarizations. The mechanisms underlying this postglutamate hyperpolarization (PGH) were investigated. PGH did not reverse polarity with hyperpolarization to potentials at or near the presumed K+ equilibrium potential. A transient increase in conductance was associated with the PGH; control values returned well before the termination of PGH. Application of Mn2+, an antagonist of voltage-dependent calcium conductance, blocked synaptic transmission and the afterhyperpolarization (AHP) that follows a directly evoked train of action potentials but did not diminish the PGH or the transient conductance increase. Intracellular application of the calcium chelator ethyleneglycol-bis(beta-aminoethylether)-N,N'-tetraacetic acid blocked AHP but did not affect PGH. Reductions in temperature from 37 to 27-32 degrees C reduced the amplitude of PGH and prolonged its duration but increased the amplitude and duration of AHP. The transient conductance increase associated with PGH was unaffected. Application of strophanthidin, a specific antagonist of Na+-K+-ATPase, reversibly blocked PGH and led to large increases in the amplitude and duration of the AHP. It is concluded that PGH is produced by activation of the electrogenic sodium pump by glutamate-induced excitation. As such, PGH is a useful physiological assay of electrogenic sodium transport. In addition, maintenance of the Na+ gradient by the sodium pump is important for the buffering of Ca2+ influx.
This article has been cited by other articles:
|
|
 |
|
  C. I. Moore and R. Cao The Hemo-Neural Hypothesis: On The Role of Blood Flow in Information Processing J Neurophysiol, May 1, 2008; 99(5): 2035 - 2047. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Brumback and K. J. Staley Thermodynamic Regulation of NKCC1-Mediated Cl- Cotransport Underlies Plasticity of GABAA Signaling in Neonatal Neurons J. Neurosci., February 6, 2008; 28(6): 1301 - 1312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Wallen, B. Robertson, L. Cangiano, P. Low, A. Bhattacharjee, L. K. Kaczmarek, and S. Grillner Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons J. Physiol., November 15, 2007; 585(1): 75 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-C. Wang and R.-C. Huang Effects of Sodium Pump Activity on Spontaneous Firing in Neurons of the Rat Suprachiasmatic Nucleus J Neurophysiol, July 1, 2006; 96(1): 109 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Williamson, P. R. Patrylo, J. Pan, D. D. Spencer, and H. Hetherington Correlations between granule cell physiology and bioenergetics in human temporal lobe epilepsy Brain, May 1, 2005; 128(5): 1199 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. F. Descalzo, L. G. Nowak, J. C. Brumberg, D. A. McCormick, and M. V. Sanchez-Vives Slow Adaptation in Fast-Spiking Neurons of Visual Cortex J Neurophysiol, February 1, 2005; 93(2): 1111 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kang, T. Notomi, M. Saito, W. Zhang, and R. Shigemoto Bidirectional Interactions between H-Channels and Na+-K+ Pumps in Mesencephalic Trigeminal Neurons J. Neurosci., April 7, 2004; 24(14): 3694 - 3702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Darbon, A. Tscherter, C. Yvon, and J. Streit Role of the Electrogenic Na/K Pump in Disinhibition-Induced Bursting in Cultured Spinal Networks J Neurophysiol, November 1, 2003; 90(5): 3119 - 3129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Sanchez-Vives, L. G. Nowak, and D. A. McCormick Membrane Mechanisms Underlying Contrast Adaptation in Cat Area 17 In Vivo J. Neurosci., June 1, 2000; 20(11): 4267 - 4285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Sanchez-Vives, L. G. Nowak, and D. A. McCormick Cellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro J. Neurosci., June 1, 2000; 20(11): 4286 - 4299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. T. Ross and I. Soltesz Selective Depolarization of Interneurons in the Early Posttraumatic Dentate Gyrus: Involvement of the Na+/K+-ATPase J Neurophysiol, May 1, 2000; 83(5): 2916 - 2930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Kim and D. A. Mccormick Functional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro J Neurophysiol, September 1, 1998; 80(3): 1222 - 1235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Klink and A. Alonso Ionic Mechanisms of Muscarinic Depolarization in Entorhinal Cortex Layer II Neurons J Neurophysiol, April 1, 1997; 77(4): 1829 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Jensen and Y. Yaari Role of Intrinsic Burst Firing, Potassium Accumulation, and Electrical Coupling in the Elevated Potassium Model of Hippocampal Epilepsy J Neurophysiol, March 1, 1997; 77(3): 1224 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Tavalin, E. F. Ellis, and L. S. Satin Inhibition of the Electrogenic Na Pump Underlies Delayed Depolarization of Cortical Neurons After Mechanical Injury or Glutamate J Neurophysiol, February 1, 1997; 77(2): 632 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ballerini, E. Bracci, and A. Nistri Pharmacological Block of the Electrogenic Sodium Pump Disrupts Rhythmic Bursting Induced by Strychnine and Bicuculline in the Neonatal Rat Spinal Cord J Neurophysiol, January 1, 1997; 77(1): 17 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Rose and B. R. Ransom Mechanisms of H+ and Na+ Changes Induced by Glutamate, Kainate, and D-Aspartate in Rat Hippocampal Astrocytes J. Neurosci., September 1, 1996; 16(17): 5393 - 5404. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
