Journal of Neurophysiology, Vol 56, Issue 3 663-682, Copyright © 1986 by APS

ARTICLES

Topography of binaural organization in primary auditory cortex of the cat: effects of changing interaural intensity

R. A. Reale and R. E. Kettner

Responses from neuron clusters were used to derive binaural and aural dominance maps within the 5- to 30-kHz frequency representation of the primary auditory cortical (AI) field in the barbiturate-anesthetized cat. Tone burst stimuli were presented dichotically using a calibrated and sealed acoustic delivery system to parametrically vary interaural intensity difference (IID). Neuron cluster responses were divided into three binaural interaction classes using audiovisual criteria: summation (56%), suppression (25%), and mixed (17%). Neurons in the summation and suppression classes demonstrated a single type of binaural interaction, regardless of intensity manipulations. Neurons in the mixed binaural class demonstrated summation responses when dichotic tonal intensities were near their threshold levels and the IID was small, but suppression responses when the IID was increased. The relative proportions of the three binaural interaction classes changed with distance along the dorsal-to-ventral isofrequency dimension. Nearly equal proportions of each class were observed at the ventral end of field AI, whereas quite different proportions of each class were seen at the dorsal extreme of the field. The average frequency of occurrence of the mixed binaural class increased nearly monotonically with increasing distance from the dorsal end of field AI. The majority of mapped AI loci exhibited a contralateral aural dominance (65%) with equidominance (25%), ipsilateral aural dominance (6%), and predominantly binaural (4%) classes accounting for the remainder. Average topographic distributions of aural dominance suggested that the ventral end of field AI consisted almost exclusively of the contralateral dominance class, whereas more equal proportions of the four classes were observed near the dorsal extreme of the field. The highest average proportions of ipsilateral aural dominance and predominantly binaural classes were found in the dorsal half of field AI. Single neurons, isolated at cortical loci assigned to the mixed binaural class during the mapping of neuron clusters, were shown to demonstrate both summation and suppression responses. Quantitative measurements relating either discharge rate or response latency to changes in the IID appeared to distinguish these cells from other single neurons studied. Typically, the probability of discharge was initially increased and subsequently decreased by progressive changes in IID that increased the intensity of the ipsilateral tone relative to the contralateral tone. The initial changes in IID characteristically shortened the latent period to the binaural response while subsequent increments in IID produced a more comp

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