Journal of Neurophysiology, Vol 60, Issue 2 798-828, Copyright © 1988 by APS

ARTICLES

Multimicroelectrode investigation of monkey striate cortex: spike train correlations in the infragranular layers

J. Kruger and F. Aiple
Neurologische Universitatsklinik, Freiburg, Federal Republic of Germany.

1. In the infragranular layers of the striate cortex of three monkeys, we studied tangential neuronal interactions by analyzing cross-correlograms calculated from spike trains recorded with 30 closely spaced microelectrodes. 2. There are two major types of correlogram structures--"narrow" peaks a few milliseconds wide, sometimes accompanied by small lateral troughs, and "broad" peaks approximately 30- to 100-ms wide. Isolated troughs are rare. Both types of structures are superimposed in the same correlograms; they are not due to shared optical stimulation. 3. In layer VI, narrow peaks are largest in a short lateral range of approximately 220 micron, and they depend on ocularity. In layer V, the lateral range is greater, and the dependency on ocularity is weak. 4. In addition, narrow peaks are largest at distances of 160 micron if the angles of preferred orientation are similar. In layer VI, however, at tangential distances of 300-400 micron, peaks are smaller, and troughs are found more often, for neuron pairs with parallel orientations compared with those with orthogonal orientations. From the agreement of this finding with a cooperative theory, we conclude that orientation selectivity is shaped by collective interactions. 5. Broad peaks always depend on ocularity, and the associated lateral interaction range exceeds the maximum of 1 mm investigated. Their size sharply decreases with receptive-field distance. 6. Average mutual delays of spikes of neuron pairs, manifest as lateral displacements of broad peaks, are interdependent; the delay between neurons 1 and 3 is the sum of that of neurons 1 and 2 and of neurons 2 and 3. This feature permits to rank the neurons on a "delay scale." 7. We conclude from 5 and 6 above that broad peaks partly result from intraretinal interactions whose effects are transmitted to the cortex via slow and fast pathways. 8. Lateral troughs adjacent to narrow peaks provide evidence that neurons at the "slow" end of the delay scale inhibit those at the "fast" end, and to a lesser extent, nondirectional neurons inhibit directional ones.

This article has been cited by other articles:

				L. C. Parr-Brownlie and B. I. Hyland Bradykinesia Induced by Dopamine D2 Receptor Blockade Is Associated with Reduced Motor Cortex Activity in the Rat J. Neurosci., June 15, 2005; 25(24): 5700 - 5709. [Abstract] [Full Text] [PDF]

				M. D. Menz and R. D. Freeman Functional Connectivity of Disparity-Tuned Neurons in the Visual Cortex J Neurophysiol, April 1, 2004; 91(4): 1794 - 1807. [Abstract] [Full Text] [PDF]

				B. B. Averbeck and D. Lee Neural Noise and Movement-Related Codes in the Macaque Supplementary Motor Area J. Neurosci., August 20, 2003; 23(20): 7630 - 7641. [Abstract] [Full Text] [PDF]

				J. D. Dorn and D. L. Ringach Estimating Membrane Voltage Correlations From Extracellular Spike Trains J Neurophysiol, April 1, 2003; 89(4): 2271 - 2278. [Abstract] [Full Text] [PDF]

				C. Constantinidis and P. S. Goldman-Rakic Correlated Discharges Among Putative Pyramidal Neurons and Interneurons in the Primate Prefrontal Cortex J Neurophysiol, December 1, 2002; 88(6): 3487 - 3497. [Abstract] [Full Text] [PDF]

				C. Constantinidis, M. N. Franowicz, and P. S. Goldman-Rakic Coding Specificity in Cortical Microcircuits: A Multiple-Electrode Analysis of Primate Prefrontal Cortex J. Neurosci., May 15, 2001; 21(10): 3646 - 3655. [Abstract] [Full Text] [PDF]

				W. Bair, E. Zohary, and W. T. Newsome Correlated Firing in Macaque Visual Area MT: Time Scales and Relationship to Behavior J. Neurosci., March 1, 2001; 21(5): 1676 - 1697. [Abstract] [Full Text] [PDF]

				S. Friedman-Hill, P. E. Maldonado, and C. M. Gray Dynamics of Striate Cortical Activity in the Alert Macaque: I. Incidence and Stimulus-dependence of Gamma-band Neuronal Oscillations Cereb Cortex, November 1, 2000; 10(11): 1105 - 1116. [Abstract] [Full Text] [PDF]

				P. E. Maldonado, S. Friedman-Hill, and C. M. Gray Dynamics of Striate Cortical Activity in the Alert Macaque: II. Fast Time Scale Synchronization Cereb Cortex, November 1, 2000; 10(11): 1117 - 1131. [Abstract] [Full Text] [PDF]

				K. D. Harris, D. A. Henze, J. Csicsvari, H. Hirase, and G. Buzsaki Accuracy of Tetrode Spike Separation as Determined by Simultaneous Intracellular and Extracellular Measurements J Neurophysiol, July 1, 2000; 84(1): 401 - 414. [Abstract] [Full Text] [PDF]

				S. Funahashi and M. Inoue Neuronal Interactions Related to Working Memory Processes in the Primate Prefrontal Cortex Revealed by Cross-correlation Analysis Cereb Cortex, June 1, 2000; 10(6): 535 - 551. [Abstract] [Full Text] [PDF]

				C. D. Brody Correlations Without Synchrony Neural Comput., October 1, 1999; 11(7): 1537 - 1551. [Abstract] [Full Text]

				S. C. de Oliveira, A. Thiele, and K.-P. Hoffmann Synchronization of Neuronal Activity during Stimulus Expectation in a Direction Discrimination Task J. Neurosci., December 1, 1997; 17(23): 9248 - 9260. [Abstract] [Full Text] [PDF]

				E. A. Stern, A. E. Kincaid, and C. J. Wilson Spontaneous Subthreshold Membrane Potential Fluctuations and Action Potential Variability of Rat Corticostriatal and Striatal Neurons In Vivo J Neurophysiol, April 1, 1997; 77(4): 1697 - 1715. [Abstract] [Full Text] [PDF]