JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 61: 681-687, 1989;
0022-3077/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Walmsley, B.
Right arrow Articles by Stuklis, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Walmsley, B.
Right arrow Articles by Stuklis, R.

Journal of Neurophysiology, Vol 61, Issue 4 681-687, Copyright © 1989 by APS

ARTICLES

Effects of spatial and temporal dispersion of synaptic input on the time course of synaptic potentials

B. Walmsley and R. Stuklis
Neural Research Laboratory, School of Anatomy, University of New South Wales, Kensington, Australia.

1. As part of the ongoing studies on the time course of single-fiber synaptic potentials recorded in spinal neurons, a theoretical analysis of the effects of spatial and temporal dispersion of synaptic input to a neuronal cable model was undertaken. 2. Results were obtained using a simple R-C soma, equivalent dendritic cylinder cable model of a neuron. Synaptic input was represented by a current injection at various points on the dendritic cable. 3. Spatial dispersion of multiple inputs to the cable model generally produced somatic transients with smooth time courses that could be closely matched by a transient generated at a single input location, usually with a different current time course. 4. Temporal dispersion, representing nonsynchronous activation of multiple synaptic contacts at the same electrotonic location, generally resulted in somatic transients with an increased rise-time and a corresponding small increase in the half-width. The somatic transient generated by these temporally dispersed inputs could usually be well matched by a single input at a different location. 5. Addition of temporal dispersion to a spatially dispersed input produced variable results in which the rise-times and half-widths of somatically recorded transients could be either increased or decreased. 6. It is concluded that a detailed knowledge of both the spatial and temporal properties of synaptic input is essential to the interpretation of single-fiber synaptic potentials. Previous results on the amplitude and time course of single-fiber synaptic potentials recorded in spinal neurons are discussed in light of the present observations.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
K. E. Jones and P. Bawa
Computer Simulation of the Responses of Human Motoneurons to Composite 1A EPSPS: Effects of Background Firing Rate
J Neurophysiol, January 1, 1997; 77(1): 405 - 420.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online