JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 61: 1161-1177, 1989;
0022-3077/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wellis, D. P.
Right arrow Articles by Harrison, T. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wellis, D. P.
Right arrow Articles by Harrison, T. A.

Journal of Neurophysiology, Vol 61, Issue 6 1161-1177, Copyright © 1989 by APS

ARTICLES

Discrimination among odorants by single neurons of the rat olfactory bulb

D. P. Wellis, J. W. Scott and T. A. Harrison
Department of Anatomy and Cell Biology, Emory University, Atlanta, Georgia 30322.

1. Intracellular and extracellular recordings were made from rat olfactory bulb mitral and tufted cells during odor stimulation and during electrical stimulation of the olfactory nerve. Neurons were identified by horseradish peroxidase injections and/or antidromic activation. The presentation of multiple concentrations of at least one odorant in a cyclic artificial sniff paradigm, as reported previously (10), allowed the study of odor responses. This approach was extended to multiple odorants to compare their concentration-response profiles. This procedure avoids the problems of interpretation resulting from nonequivalence of the effective concentrations of different odorants used as stimuli that have characterized previous studies of odor quality effects. Comparisons of intracellular events and responses to electrical stimulation with the odor-induced spike train activity allow us to begin to delineate the local circuitry involved in generating odor-induced responses. 2. The concentration-response profiles of the 72 cells in the present study are comparable to those previously reported for output neurons of the olfactory bulb, showing ordered changes in the temporal patterning of spike activity with step changes in odor concentration. However, eight of the neurons exhibited inhibitory responses to lower concentrations, but excitation, at similar latency, to higher concentrations of the same odorant. These data emphasize that to study pattern changes induced by changing odor quality the influence of stimulus intensity must also be carefully examined. The data also provide evidence that the temporal pattern evoked by an odorant is probably not in itself the code for odor quality recognition. 3. Complete concentration-response profiles, including subthreshold concentrations, to more than one odorant show that, although responses to the different odorant can evolve systematically with concentration, the responses to different odorants can evolve through very different patterns. For example, in some cells, the response patterns to different odors were complementary in form. These results demonstrate that the patterned responses of olfactory bulb neurons can reflect changes in odor quality as well as intensity. 4. Intracellular recording was employed to compare the temporal patterning of spikes during odor stimulation with membrane potential changes. In some cases, the spike pattern was closely correlated with apparent postsynaptic potentials. However, there were several clear exceptions. In five cells, a prominent hyperpolarization, seen in the first sniff of a series of 10 consecutive sniffs, was associated with pauses in spike activity. In the following


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
R. A. Fuentes, M. I. Aguilar, M. L. Aylwin, and P. E. Maldonado
Neuronal Activity of Mitral-Tufted Cells in Awake Rats During Passive and Active Odorant Stimulation
J Neurophysiol, July 1, 2008; 100(1): 422 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
K. A. Hamilton, S. Parrish-Aungst, F. L. Margolis, F. Erdelyi, G. Szabo, and A. C. Puche
Sensory Deafferentation Transsynaptically Alters Neuronal GluR1 Expression in the External Plexiform Layer of the Adult Mouse Main Olfactory Bulb
Chem Senses, February 1, 2008; 33(2): 201 - 210.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. G. Davison and L. C. Katz
Sparse and Selective Odor Coding by Mitral/Tufted Neurons in the Main Olfactory Bulb
J. Neurosci., February 21, 2007; 27(8): 2091 - 2101.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. A. Cleland, B. A. Johnson, M. Leon, and C. Linster
Relational representation in the olfactory system
PNAS, February 6, 2007; 104(6): 1953 - 1958.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
J. W. Scott
Sniffing and Spatiotemporal Coding in Olfaction
Chem Senses, February 1, 2006; 31(2): 119 - 130.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Spors, M. Wachowiak, L. B. Cohen, and R. W. Friedrich
Temporal Dynamics and Latency Patterns of Receptor Neuron Input to the Olfactory Bulb
J. Neurosci., January 25, 2006; 26(4): 1247 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
T. A. Cleland and C. Linster
Computation in the Olfactory System
Chem Senses, November 1, 2005; 30(9): 801 - 813.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. I. Wilson and G. Laurent
Role of GABAergic Inhibition in Shaping Odor-Evoked Spatiotemporal Patterns in the Drosophila Antennal Lobe
J. Neurosci., October 5, 2005; 25(40): 9069 - 9079.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P.-M. Lledo, G. Gheusi, and J.-D. Vincent
Information Processing in the Mammalian Olfactory System
Physiol Rev, January 1, 2005; 85(1): 281 - 317.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
A.M. McNamara, T.A. Cleland, and C. Linster
Characterization of the Synaptic Properties of Olfactory Bulb Projections
Chem Senses, March 1, 2004; 29(3): 225 - 233.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Halabisky and B. W. Strowbridge
{gamma}-Frequency Excitatory Input to Granule Cells Facilitates Dendrodendritic Inhibition in the Rat Olfactory Bulb
J Neurophysiol, August 1, 2003; 90(2): 644 - 654.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. L. Fletcher and D. A. Wilson
Olfactory Bulb Mitral-Tufted Cell Plasticity: Odorant-Specific Tuning Reflects Previous Odorant Exposure
J. Neurosci., July 30, 2003; 23(17): 6946 - 6955.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Debarbieux, E. Audinat, and S. Charpak
Action Potential Propagation in Dendrites of Rat Mitral Cells In Vivo
J. Neurosci., July 2, 2003; 23(13): 5553 - 5560.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Cang and J. S. Isaacson
In Vivo Whole-Cell Recording of Odor-Evoked Synaptic Transmission in the Rat Olfactory Bulb
J. Neurosci., May 15, 2003; 23(10): 4108 - 4116.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
T. K. Alkasab, J. White, and J. S. Kauer
A Computational System for Simulating and Analyzing Arrays of Biological and Artificial Chemical Sensors
Chem Senses, March 1, 2002; 27(3): 261 - 275.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. R. McQuiston and L. C. Katz
Electrophysiology of Interneurons in the Glomerular Layer of the Rat Olfactory Bulb
J Neurophysiol, October 1, 2001; 86(4): 1899 - 1907.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. D. Protopapas and J. M. Bower
Spike Coding in Pyramidal Cells of the Piriform Cortex of Rat
J Neurophysiol, September 1, 2001; 86(3): 1504 - 1510.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P.-A. Salin, P.-M. Lledo, J.-D. Vincent, and S. Charpak
Dendritic Glutamate Autoreceptors Modulate Signal Processing in Rat Mitral Cells
J Neurophysiol, March 1, 2001; 85(3): 1275 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Meister and T. Bonhoeffer
Tuning and Topography in an Odor Map on the Rat Olfactory Bulb
J. Neurosci., February 15, 2001; 21(4): 1351 - 1360.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. W. Friedrich and G. Laurent
Dynamic Optimization of Odor Representations by Slow Temporal Patterning of Mitral Cell Activity
Science, February 2, 2001; 291(5505): 889 - 894.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. A. Wilson
Comparison of Odor Receptive Field Plasticity in the Rat Olfactory Bulb and Anterior Piriform Cortex
J Neurophysiol, December 1, 2000; 84(6): 3036 - 3042.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Desmaisons, J.-D. Vincent, and P.-M. Lledo
Control of Action Potential Timing by Intrinsic Subthreshold Oscillations in Olfactory Bulb Output Neurons
J. Neurosci., December 15, 1999; 19(24): 10727 - 10737.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
P. Duchamp-Viret, M. A. Chaput, and A. Duchamp
Odor Response Properties of Rat Olfactory Receptor Neurons
Science, June 25, 1999; 284(5423): 2171 - 2174.
[Abstract] [Full Text]

Home page
 Ann. N. Y. Acad. Sci.Home page
T. A. CHRISTENSEN, B. R. WALDROP, and J. G. HILDEBRAND
GABAergic Mechanisms That Shape the Temporal Response to Odors in Moth Olfactory Projection Neurons
Ann. N.Y. Acad. Sci., November 30, 1998; 855(1): 475 - 481.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. A. Christensen, B. R. Waldrop, and J. G. Hildebrand
Multitasking in the Olfactory System: Context-Dependent Responses to Odors Reveal Dual GABA-Regulated Coding Mechanisms in Single Olfactory Projection Neurons
J. Neurosci., August 1, 1998; 18(15): 5999 - 6008.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. A. Wilson
Habituation of Odor Responses in the Rat Anterior Piriform Cortex
J Neurophysiol, March 1, 1998; 79(3): 1425 - 1440.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. A. Christensen and J. G. Hildebrand
Coincident Stimulation With Pheromone Components Improves Temporal Pattern Resolution in Central Olfactory Neurons
J Neurophysiol, February 1, 1997; 77(2): 775 - 781.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Jiang, E. R. Griff, M. Ennis, L. A. Zimmer, and M. T. Shipley
Activation of Locus Coeruleus Enhances the Responses of Olfactory Bulb Mitral Cells to Weak Olfactory Nerve Input
J. Neurosci., October 1, 1996; 16(19): 6319 - 6329.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online