JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 62: 609-625, 1989;
0022-3077/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hamilton, K. A.
Right arrow Articles by Kauer, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hamilton, K. A.
Right arrow Articles by Kauer, J. S.

Journal of Neurophysiology, Vol 62, Issue 3 609-625, Copyright © 1989 by APS

ARTICLES

Patterns of intracellular potentials in salamander mitral/tufted cells in response to odor stimulation

K. A. Hamilton and J. S. Kauer
Department of Neurosurgery, New England Medical Center, Tufts Medical School, Boston, Massachusetts 02111.

1. Changes in membrane potential and temporal patterns of spikes were analyzed in 30 output cells in the salamander olfactory bulb in response to stimulation with 1-s pulses of the odorants isoamyl acetate, cineole, and camphor. The odor responses were more complex than responses to electrical stimulation of the olfactory nerve or olfactory tracts, with which they were compared. Most began with hyperpolarization and contained prolonged hyperpolarizing and depolarizing potentials that appeared to be compound postsynaptic potentials. These potentials were related to periods of spike inhibition and excitation. The temporal patterns of the responses resembled S-type (for suppression) and E-type (for excitation) patterns described previously in extracellular-unit studies. 2. In single cells, graded but nonmonotonic changes in the responses were observed with increases in the odor concentration from 10(-3) to 10(-1) vapor-phase saturation. Abrupt changes from one category of temporal response pattern to another were generally not observed in response to different concentrations of a single odorant but were frequently observed when the stimulus was changed from one odorant to another. 3. In S-type patterns, the first event was always membrane hyperpolarization and spike inhibition, regardless of the odor concentration. At all concentrations, simple S-type responses were observed in which a single period of hyperpolarization and inhibition lasted several seconds. At moderate to high concentrations, complex S-type responses were observed in which a period of excitation followed an initial period of hyperpolarization and inhibition. In these responses, spikes were often elicited near the termination of the odor pulse, occasionally as early as 300-400 ms after pulse onset. A prolonged period of inhibition followed the period of excitation. 4. In E-type patterns, the first event depended on the odor concentration. At all concentrations, complex responses were observed in which a period of excitation occurred with short latency, followed by a period of inhibition. At low to moderate concentrations, a brief initial period of hyperpolarization preceded the excitation. This initial period of hyperpolarization was always shorter than those in complex S-type responses to equivalent concentrations. However, the range of spike latencies overlapped that of S-type responses to high concentrations. With increasing odor concentration, spike latencies in the E-type responses decreased relative to the onset and peak of the initial hyperpolarization. At high concentrations. spikes were frequently elicited preceding a single period of hyperpolarization and inhibition.(ABSTRACT TRUNCATED AT 400 WORDS)


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
R. Balu, R. T. Pressler, and B. W. Strowbridge
Multiple Modes of Synaptic Excitation of Olfactory Bulb Granule Cells
J. Neurosci., May 23, 2007; 27(21): 5621 - 5632.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Balu and B. W. Strowbridge
Opposing Inward and Outward Conductances Regulate Rebound Discharges in Olfactory Mitral Cells
J Neurophysiol, March 1, 2007; 97(3): 1959 - 1968.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. A. Cleland, B. A. Johnson, M. Leon, and C. Linster
Relational representation in the olfactory system
PNAS, February 6, 2007; 104(6): 1953 - 1958.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Kapoor and N. N. Urban
Glomerulus-specific, long-latency activity in the olfactory bulb granule cell network.
J. Neurosci., November 8, 2006; 26(45): 11709 - 11719.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. B. Rubin and T. A. Cleland
Dynamical Mechanisms of Odor Processing in Olfactory Bulb Mitral Cells
J Neurophysiol, August 1, 2006; 96(2): 555 - 568.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. B. Dietz and V. N. Murthy
Contrasting short-term plasticity at two sides of the mitral-granule reciprocal synapse in the mammalian olfactory bulb
J. Physiol., December 1, 2005; 569(2): 475 - 488.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. I. Wilson and G. Laurent
Role of GABAergic Inhibition in Shaping Odor-Evoked Spatiotemporal Patterns in the Drosophila Antennal Lobe
J. Neurosci., October 5, 2005; 25(40): 9069 - 9079.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. G. Davison, J. D. Boyd, and K. R. Delaney
Dopamine Inhibits Mitral/Tufted-> Granule Cell Synapses in the Frog Olfactory Bulb
J. Neurosci., September 15, 2004; 24(37): 8057 - 8067.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Balu, P. Larimer, and B. W. Strowbridge
Phasic Stimuli Evoke Precisely Timed Spikes in Intermittently Discharging Mitral Cells
J Neurophysiol, August 1, 2004; 92(2): 743 - 753.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Djurisic, S. Antic, W. R. Chen, and D. Zecevic
Voltage Imaging from Dendrites of Mitral Cells: EPSP Attenuation and Spike Trigger Zones
J. Neurosci., July 28, 2004; 24(30): 6703 - 6714.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
N. Suzuki, M. Takahata, T. Shoji, and Y. Suzuki
Characterization of Electro-olfactogram Oscillations and Their Computational Reconstruction
Chem Senses, June 1, 2004; 29(5): 411 - 424.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. L. Fletcher and D. A. Wilson
Olfactory Bulb Mitral-Tufted Cell Plasticity: Odorant-Specific Tuning Reflects Previous Odorant Exposure
J. Neurosci., July 30, 2003; 23(17): 6946 - 6955.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Cang and J. S. Isaacson
In Vivo Whole-Cell Recording of Odor-Evoked Synaptic Transmission in the Rat Olfactory Bulb
J. Neurosci., May 15, 2003; 23(10): 4108 - 4116.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. S. Deshmukh and U. S. Bhalla
Representation of Odor Habituation and Timing in the Hippocampus
J. Neurosci., March 1, 2003; 23(5): 1903 - 1915.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
T. K. Alkasab, J. White, and J. S. Kauer
A Computational System for Simulating and Analyzing Arrays of Biological and Artificial Chemical Sensors
Chem Senses, March 1, 2002; 27(3): 261 - 275.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. W. Friedrich and G. Laurent
Dynamic Optimization of Odor Representations by Slow Temporal Patterning of Mitral Cell Activity
Science, February 2, 2001; 291(5505): 889 - 894.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Friedman and B. W. Strowbridge
Functional Role of NMDA Autoreceptors in Olfactory Mitral Cells
J Neurophysiol, July 1, 2000; 84(1): 39 - 50.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. M. Dorries and J. S. Kauer
Relationships Between Odor-Elicited Oscillations in the Salamander Olfactory Epithelium and Olfactory Bulb
J Neurophysiol, February 1, 2000; 83(2): 754 - 765.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Wehr and G. Laurent
Relationship between Afferent and Central Temporal Patterns in the Locust Olfactory System
J. Neurosci., January 1, 1999; 19(1): 381 - 390.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
T. A. CHRISTENSEN, B. R. WALDROP, and J. G. HILDEBRAND
GABAergic Mechanisms That Shape the Temporal Response to Odors in Moth Olfactory Projection Neurons
Ann. N.Y. Acad. Sci., November 30, 1998; 855(1): 475 - 481.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. E. Schoppa, J. M. Kinzie, Y. Sahara, T. P. Segerson, and G. L. Westbrook
Dendrodendritic Inhibition in the Olfactory Bulb Is Driven by NMDA Receptors
J. Neurosci., September 1, 1998; 18(17): 6790 - 6802.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. A. Christensen, B. R. Waldrop, and J. G. Hildebrand
Multitasking in the Olfactory System: Context-Dependent Responses to Odors Reveal Dual GABA-Regulated Coding Mechanisms in Single Olfactory Projection Neurons
J. Neurosci., August 1, 1998; 18(15): 5999 - 6008.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. A. Christensen and J. G. Hildebrand
Coincident Stimulation With Pheromone Components Improves Temporal Pattern Resolution in Central Olfactory Neurons
J Neurophysiol, February 1, 1997; 77(2): 775 - 781.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
D. W. Tank, A. Gelperin, and D. Kleinfeld
Odors, Oscillations, and Waves: Does It All Compute?
Science, September 23, 1994; 265(5180): 1819 - 1820.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online