Journal of Neurophysiology, Vol 64, Issue 5 1527-1536, Copyright © 1990 by APS

ARTICLES

Three-dimensional analysis of auditory-evoked potentials in rat neocortex

D. S. Barth and S. Di
Department of Psychology, University of Colorado, Boulder 80309.

1. A 8 X 8-channel microelectrode array was used to map epicortical field potentials evoked by bilaterally presented click stimuli from a 8 X 8-mm2 area in the right parietotemporal neocortex of four rats. In two rats, a 16-channel microelectrode array was also inserted into primary auditory cortex to record the laminar profile of auditory evoked potentials (AEP). 2. The epicortical responses began with a positive-negative fast wave followed by a positive-negative slow wave, similar to the previously reported P1, N1, P2, N2 complex. Topographical distributions of the potentials at the peak of each of these waves were distinct, suggesting that they were produced by separate but overlapping populations of cells. 3. Laminar recording revealed the asynchronous participation of supragranular and infragranular pyramidal cells in the generation of the evoked-response complex. The surface-recorded P1 was primarily produced by supragranular cells and the N1, by infragranular cells. The P2 and N2 were produced by temporally overlapping contributions from both cell groups. 4. We conclude that middle-latency components of the AEP complex are produced by both sequential and parallel activation of subpopulations of pyramidal cells in primary auditory cortex.

This article has been cited by other articles:

				R. J Staba, P. C Bergmann, and D. S Barth Dissociation of slow waves and fast oscillations above 200 Hz during GABA application in rat somatosensory cortex J. Physiol., November 15, 2004; 561(1): 205 - 214. [Abstract] [Full Text] [PDF]

				A. V. Medvedev and J. S. Kanwal Local Field Potentials and Spiking Activity in the Primary Auditory Cortex in Response to Social Calls J Neurophysiol, July 1, 2004; 92(1): 52 - 65. [Abstract] [Full Text] [PDF]

				S. Kaur, R. Lazar, and R. Metherate Intracortical Pathways Determine Breadth of Subthreshold Frequency Receptive Fields in Primary Auditory Cortex J Neurophysiol, June 1, 2004; 91(6): 2551 - 2567. [Abstract] [Full Text] [PDF]

				B. Brett-Green, M. Paulsen, R. J. Staba, E. Fifkova, and D. S. Barth Two Distinct Regions of Secondary Somatosensory Cortex in the Rat: Topographical Organization and Multisensory Responses J Neurophysiol, March 1, 2004; 91(3): 1327 - 1336. [Abstract] [Full Text] [PDF]

				S. J. Cruikshank, H. J. Rose, and R. Metherate Auditory Thalamocortical Synaptic Transmission In Vitro J Neurophysiol, January 1, 2002; 87(1): 361 - 384. [Abstract] [Full Text] [PDF]

				S. K. Talwar, P. G. Musial, and G. L. Gerstein Role of Mammalian Auditory Cortex in the Perception of Elementary Sound Properties J Neurophysiol, June 1, 2001; 85(6): 2350 - 2358. [Abstract] [Full Text] [PDF]

				W. Sukov and D. S. Barth Cellular Mechanisms of Thalamically Evoked Gamma Oscillations in Auditory Cortex J Neurophysiol, March 1, 2001; 85(3): 1235 - 1245. [Abstract] [Full Text] [PDF]

				M. S. Jones, K. D. MacDonald, B. Choi, F. E. Dudek, and D. S. Barth Intracellular Correlates of Fast (>200 Hz) Electrical Oscillations in Rat Somatosensory Cortex J Neurophysiol, September 1, 2000; 84(3): 1505 - 1518. [Abstract] [Full Text] [PDF]

				B. J. Hefti and P. H. Smith Anatomy, Physiology, and Synaptic Responses of Rat Layer V Auditory Cortical Cells and Effects of Intracellular GABAA Blockade J Neurophysiol, May 1, 2000; 83(5): 2626 - 2638. [Abstract] [Full Text] [PDF]

				F. W. Ohl, H. Scheich, and W. J. Freeman Topographic Analysis of Epidural Pure-Tone-Evoked Potentials in Gerbil Auditory Cortex J Neurophysiol, May 1, 2000; 83(5): 3123 - 3132. [Abstract] [Full Text] [PDF]

				W. Sukov and D. S. Barth Three-Dimensional Analysis of Spontaneous and Thalamically Evoked Gamma Oscillations in Auditory Cortex J Neurophysiol, June 1, 1998; 79(6): 2875 - 2884. [Abstract] [Full Text] [PDF]

				B. Brett and D. S. Barth Subcortical Modulation of High-Frequency (Gamma Band) Oscillating Potentials in Auditory Cortex J Neurophysiol, August 1, 1997; 78(2): 573 - 581. [Abstract] [Full Text] [PDF]