JN Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 65: 141-147, 1991;
0022-3077/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Muller, W.
Right arrow Articles by Misgeld, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Muller, W.
Right arrow Articles by Misgeld, U.

Journal of Neurophysiology, Vol 65, Issue 1 141-147, Copyright © 1991 by APS

ARTICLES

Picrotoxin- and 4-aminopyridine-induced activity in hilar neurons in the guinea pig hippocampal slice

W. Muller and U. Misgeld
Abteilung Neurophysiologie, Max-Planck Institut fur Psychatrie, Martinsried, Federal Republic of Germany.

1. Paired extra- and intracellular recording was used to study the activity of neurons in the dentate hilus and their interaction with CA3/CA4 pyramidal neurons and granule cells during picrotoxin- or 4-aminopyridine (4-AP)-induced rhythmical activity in the guinea pig hippocampal slice. 2. Picrotoxin induced synchronous repetitive population spikes in the CA3, CA4, and hilar region, but no extracellular activity in the granule cell layer. 4-AP induced rhythmically occurring positive field-potential waves in the CA3, CA4, and granular layer coincident to negative/positive field potentials in the hilus. 3. Picrotoxin-induced activity originated in the CA3 area and subsequently appeared in the CA4 and hilar region, whereas 4-AP-induced activity appeared simultaneously in all subfields. 4. Blockade of fast glutamatergic excitation by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 microM) blocked the picrotoxin-induced activity but not the 4-AP-induced activity. 5. Focal application of tetrodotoxin (TTX) between area CA3 and CA4 blocked picrotoxin-induced activity in the CA4 and hilar region but decoupled 4-AP-induced activity in the CA3 area. 6. Under intracellular recording, picrotoxin induced bursts in CA3, CA4, and hilar neurons but K-dependent slow IPSPs in granule cells. 4-AP induced rhythmically occurring burst in hilar neurons synchronous to Cl- and K-dependent IPSPs in CA3, CA4, and granule cells. 7. Comparison of picrotoxin- and 4-AP-induced rhythmical burst activity reveals that many hilar neurons are excited by CA3/CA4 pyramidal neurons in addition to the well-known excitation by granule cells and perforant path fibers, and that, in turn, many hilar neurons inhibit CA3, CA4, and granule cells.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
B. Nahir, C. Bhatia, and C. J. Frazier
Presynaptic Inhibition of Excitatory Afferents to Hilar Mossy Cells
J Neurophysiol, June 1, 2007; 97(6): 4036 - 4047.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F Manseau, M Danik, and S Williams
A functional glutamatergic neurone network in the medial septum and diagonal band area
J. Physiol., August 1, 2005; 566(3): 865 - 884.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. Muller and K. Bittner
Differential Oxidative Modulation of Voltage-Dependent K+ Currents in Rat Hippocampal Neurons
J Neurophysiol, June 1, 2002; 87(6): 2990 - 2995.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. D. Traub, R. Bibbig, A. Piechotta, R. Draguhn, and D. Schmitz
Synaptic and Nonsynaptic Contributions to Giant IPSPs and Ectopic Spikes Induced by 4-Aminopyridine in the Hippocampus In Vitro
J Neurophysiol, March 1, 2001; 85(3): 1246 - 1256.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. E. Scharfman, J. H. Goodman, and A. L. Sollas
Granule-Like Neurons at the Hilar/CA3 Border after Status Epilepticus and Their Synchrony with Area CA3 Pyramidal Cells: Functional Implications of Seizure-Induced Neurogenesis
J. Neurosci., August 15, 2000; 20(16): 6144 - 6158.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Borck and J. G. R. Jefferys
Seizure-Like Events in Disinhibited Ventral Slices of Adult Rat Hippocampus
J Neurophysiol, November 1, 1999; 82(5): 2130 - 2142.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. W. Strowbridge
Glutamate Receptors Mediate TTX-Resistant Synchronous Activity in the Rat Hippocampus
J. Neurosci., July 15, 1999; 19(14): 5758 - 5767.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Golshani and E. G. Jones
Synchronized Paroxysmal Activity in the Developing Thalamocortical Network Mediated by Corticothalamic Projections and "Silent" Synapses
J. Neurosci., April 15, 1999; 19(8): 2865 - 2875.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. M. Pham, S. Nurse, and J.-C. Lacaille
Distinct GABAB Actions Via Synaptic and Extrasynaptic Receptors in Rat Hippocampus In Vitro
J Neurophysiol, July 1, 1998; 80(1): 297 - 308.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. R. Bramham
Phasic Boosting of Medial Perforant Path-Evoked Granule Cell Output Time-Locked to Spontaneous Dentate EEG Spikes in Awake Rats
J Neurophysiol, June 1, 1998; 79(6): 2825 - 2832.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Forti and H. B. Michelson
Synaptic Connectivity of Distinct Hilar Interneuron Subpopulations
J Neurophysiol, June 1, 1998; 79(6): 3229 - 3237.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
K. Staley, B. Soldo, and W. Proctor
Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors
Science, August 18, 1995; 269(5226): 977 - 981.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online