JN AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 67: 841-851, 1992;
0022-3077/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (73)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bear, M. F.
Right arrow Articles by Connors, B. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bear, M. F.
Right arrow Articles by Connors, B. W.

Journal of Neurophysiology, Vol 67, Issue 4 841-851, Copyright © 1992 by APS

ARTICLES

Long-term potentiation in slices of kitten visual cortex and the effects of NMDA receptor blockade

M. F. Bear, W. A. Press and B. W. Connors
Department of Neuroscience, Brown University, Providence, Rhode Island 02912.

1. A slice preparation was used to study layer III field potentials (FPs) evoked by electrical stimulation of the white matter-layer VI border and their potentiation by patterned stimuli. 2. The dependence of the FP on recording position was investigated. The maximum field was recorded in layer III at a position radial to the site of stimulation. Because this negative FP reflects an excitatory synaptic current sink, this site was chosen for all subsequent experiments. 3. Under normal recording conditions, components of the layer III FP with latencies greater than 3 ms were completely abolished by kynurenate but unaffected by 2-amino-5-phosphonovalerate (AP5), indicating that this potential reflects the activation of non-NMDA excitatory amino acid receptors. 4. Addition of the gamma-aminobutyric acid (GABA)A receptor antagonist bicuculline methiodide (BMI) broadened the field potential and revealed an AP5-sensitive component. By filling the recording pipette with BMI, it was possible to substantially reduce inhibition locally around the recording site while avoiding stimulus-driven and spontaneous epileptiform activity. 5. Tetanic stimulation elicited a long-term potentiation (LTP) of the FP in 14 of 17 experiments when the BMI-filled pipette method was used. 6. Addition of 100 microM D,L-AP5 significantly reduced the average probability and magnitude of LTP. Nonetheless, in 2 of 8 experiments, significant LTP was observed after a tetanus in the presence of AP5. Control experiments confirmed that this concentration of AP5 was sufficient to maximally block cortical NMDA receptors. 7. We conclude that LTP of layer III field potentials can be reliably elicited, provided that GABAA-receptor mediated inhibition is blocked locally at the site of recording and that NMDA receptors are recruited during the conditioning stimulation. However, activation of NMDA receptors is apparently not an obligatory step for the induction of use-dependent increases in synaptic strength in the kitten striate cortex.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
V. S. Dani and S. B. Nelson
Intact Long-Term Potentiation but Reduced Connectivity between Neocortical Layer 5 Pyramidal Neurons in a Mouse Model of Rett Syndrome
J. Neurosci., September 9, 2009; 29(36): 11263 - 11270.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J.-W. Yi, B.-J. Lee, D.-O. Kim, S.-W. Park, Y.-K. Choi, H.-K. Chang, C.-J. Kim, and J.-H. Park
Effects of bupivacaine and ropivacaine on field potential in rat hippocampal slices
Br. J. Anaesth., May 1, 2009; 102(5): 673 - 679.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Sarihi, B. Jiang, A. Komaki, K. Sohya, Y. Yanagawa, and T. Tsumoto
Metabotropic Glutamate Receptor Type 5-Dependent Long-Term Potentiation of Excitatory Synapses on Fast-Spiking GABAergic Neurons in Mouse Visual Cortex
J. Neurosci., January 30, 2008; 28(5): 1224 - 1235.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
S. Crochet, P. Fuentealba, Y. Cisse, I. Timofeev, and M. Steriade
Synaptic Plasticity in Local Cortical Network In Vivo and Its Modulation by the Level of Neuronal Activity
Cereb Cortex, May 1, 2006; 16(5): 618 - 631.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
V. S. Dani, Q. Chang, A. Maffei, G. G. Turrigiano, R. Jaenisch, and S. B. Nelson
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett Syndrome
PNAS, August 30, 2005; 102(35): 12560 - 12565.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. Thomsen, N. Offenhauser, and M. Lauritzen
Principal neuron spiking: neither necessary nor sufficient for cerebral blood flow in rat cerebellum
J. Physiol., October 1, 2004; 560(1): 181 - 189.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Birtoli and D. Ulrich
Firing Mode-Dependent Synaptic Plasticity in Rat Neocortical Pyramidal Neurons
J. Neurosci., May 26, 2004; 24(21): 4935 - 4940.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Yoshimura, T. Ohmura, and Y. Komatsu
Two Forms of Synaptic Plasticity with Distinct Dependence on Age, Experience, and NMDA Receptor Subtype in Rat Visual Cortex
J. Neurosci., July 23, 2003; 23(16): 6557 - 6566.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Huang and S. L. Pallas
NMDA Antagonists in the Superior Colliculus Prevent Developmental Plasticity But Not Visual Transmission or Map Compression
J Neurophysiol, September 1, 2001; 86(3): 1179 - 1194.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. P. Perrett, S. M. Dudek, D. Eagleman, P. R. Montague, and M. J. Friedlander
LTD Induction in Adult Visual Cortex: Role of Stimulus Timing and Inhibition
J. Neurosci., April 1, 2001; 21(7): 2308 - 2319.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Edagawa, H. Saito, and K. Abe
Endogenous Serotonin Contributes to a Developmental Decrease in Long-Term Potentiation in the Rat Visual Cortex
J. Neurosci., March 1, 2001; 21(5): 1532 - 1537.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
C. Bell, V. Han, Y Sugawara, and K Grant
Synaptic plasticity in the mormyrid electrosensory lobe
J. Exp. Biol., January 5, 1999; 202(10): 1339 - 1347.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
E. M. Finney and C. J. Shatz
Establishment of Patterned Thalamocortical Connections Does Not Require Nitric Oxide Synthase
J. Neurosci., November 1, 1998; 18(21): 8826 - 8838.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Rumpel, H. Hatt, and K. Gottmann
Silent Synapses in the Developing Rat Visual Cortex: Evidence for Postsynaptic Expression of Synaptic Plasticity
J. Neurosci., November 1, 1998; 18(21): 8863 - 8874.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Tighilet, T. Hashikawa, and E. G. Jones
Cell- and Lamina-Specific Expression and Activity-Dependent Regulation of Type II Calcium/Calmodulin-Dependent Protein Kinase Isoforms in Monkey Visual Cortex
J. Neurosci., March 15, 1998; 18(6): 2129 - 2146.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Kaneko and D. L. Hammond
Role of Spinal gamma -Aminobutyric AcidA Receptors in Formalin-Induced Nociception in the Rat
J. Pharmacol. Exp. Ther., August 1, 1997; 282(2): 928 - 938.
[Abstract] [Full Text]

Home page
 NeuroscientistHome page
L. M. Schultz
REVIEW {blacksquare} : GABAergic Inhibitory Processes and Hippocampal Long-term Potentiation
Neuroscientist, July 1, 1997; 3(4): 226 - 236.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online