| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 68, Issue 2 485-495, Copyright © 1992 by APS
ARTICLES |
O. Kiehn and R. M. Harris-Warrick
Section of Neurobiology and Behavior, Cornell University, Ithaca, New York 14853.
1. The mechanisms for induction of bistable plateau potential properties by a set of serotonergic/cholinergic peripheral stretch receptor cells [gastropyloric receptor (GPR) cells] were examined in the crab stomatogastric ganglion (STG) with the use of intracellular recording techniques. 2. GPR cell stimulation evoked nicotinic excitatory postsynaptic potentials (EPSPs) and induced plateau potential capability in the dorsal gastric (DG) motor neuron. The plateau potential could be triggered during a GPR train either by the summating nicotinic EPSPs or by brief intracellular current injection. After pharmacological blockade of nicotinic and muscarinic receptors, a slow depolarization in response to GPR stimulation was revealed. Prolonged plateau potentials could still be evoked after this treatment. Local application of serotonin (5-HT; 10 microM to 1 mM) mimicked the noncholinergic plateau inducing effects of GPR stimulation in the DG motor neuron. 3. The synergistic action of acetylcholine (ACh) and 5-HT was examined by stimulating the GPR cells at different frequencies (1-20 Hz). The plateau induction was present down to 2 Hz. The time to onset for triggering a plateau during a GPR train was determined by the co-released ACh. 4. The 5-HT-evoked slow depolarization persisted in tetrodotoxin (TTX; 0.1-1 microM), and the DG motor neuron could still produce a plateau potential on brief depolarization in the absence of the spike-generating mechanism. 5. In normal TTX-containing saline, the 5-HT-evoked depolarization was accompanied by a weak and variable decrease in apparent input conductance. After substituting one-half of the extracellular sodium with either Trisma-HCl or choline, the decrease in apparent input conductance became more pronounced. This decrease was converted to an increase in apparent input conductance when extracellular Ca2+ was replaced with Mg2+. 6. Under voltage-clamp conditions, local application of 5-HT caused a slow inward current of prolonged duration in DG. The current versus voltage relationship had an inverted U-shape with no apparent reversal potential in the entire voltage range investigated (-90 to -5 mV). The 5-HT-induced changes in input conductance showed a complex voltage dependence, with a conductance decrease from moderately depolarized voltages. 7. Extracellular Cs+ (2-4 mM) caused the DG to hyperpolarize 2-4 mV from rest, whereas lowering extracellular Ca2+ caused it to depolarize 7-15 mV. The combined action of low extracellular Ca2+ and 2-4 mM Cs+ caused an almost complete block of the slow 5-HT-evoked depolarization.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
|
|
 |
|
  S. R. Saideman, A. E. Christie, P. Torfs, J. Huybrechts, L. Schoofs, and M. P. Nusbaum Actions of kinin peptides in the stomatogastric ganglion of the crab Cancer borealis J. Exp. Biol., September 15, 2006; 209(18): 3664 - 3676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Harvey, Y. Li, X. Li, and D. J. Bennett Persistent Sodium Currents and Repetitive Firing in Motoneurons of the Sacrocaudal Spinal Cord of Adult Rats J Neurophysiol, September 1, 2006; 96(3): 1141 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Le, D. R. Verley, J.-M. Goaillard, D. I. Messinger, A. E. Christie, and J. T. Birmingham Bistable Behavior Originating in the Axon of a Crustacean Motor Neuron J Neurophysiol, March 1, 2006; 95(3): 1356 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Beenhakker, N. D. DeLong, S. R. Saideman, F. Nadim, and M. P. Nusbaum Proprioceptor Regulation of Motor Circuit Activity by Presynaptic Inhibition of a Modulatory Projection Neuron J. Neurosci., September 21, 2005; 25(38): 8794 - 8806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Mercer, P. Kloppenburg, and J. G. Hildebrand Plateau Potentials in Developing Antennal-Lobe Neurons of the Moth, Manduca sexta J Neurophysiol, April 1, 2005; 93(4): 1949 - 1958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Blitz, M. P. Beenhakker, and M. P. Nusbaum Different Sensory Systems Share Projection Neurons But Elicit Distinct Motor Patterns J. Neurosci., December 15, 2004; 24(50): 11381 - 11390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Clark, T. E. Dever, J. J. Dever, P. Xu, V. Rehder, M. A. Sosa, and D. J. Baro Arthropod 5-HT2 Receptors: A Neurohormonal Receptor in Decapod Crustaceans That Displays Agonist Independent Activity Resulting from an Evolutionary Alteration to the DRY Motif J. Neurosci., March 31, 2004; 24(13): 3421 - 3435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Le Bon-Jego, D. Cattaert, and E. Pearlstein Serotonin Enhances the Resistance Reflex of the Locomotor Network of the Crayfish through Multiple Modulatory Effects that Act Cooperatively J. Neurosci., January 14, 2004; 24(2): 398 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Beenhakker, D. M. Blitz, and M. P. Nusbaum Long-Lasting Activation of Rhythmic Neuronal Activity by a Novel Mechanosensory System in the Crustacean Stomatogastric Nervous System J Neurophysiol, January 1, 2004; 91(1): 78 - 91. [Abstract] [Full Text]
|
|
|
|
|
|
F.-S. Lo and R. S. Erzurumlu L-Type Calcium Channel-Mediated Plateau Potentials in Barrelette Cells During Structural Plasticity J Neurophysiol, August 1, 2002; 88(2): 794 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Skiebe Neuropeptides are ubiquitous chemical mediators: Using the stomatogastric nervous system as a model system J. Exp. Biol., March 8, 2002; 204(12): 2035 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Duch and R. B. Levine Changes in Calcium Signaling During Postembryonic Dendritic Growth in Manduca sexta J Neurophysiol, March 1, 2002; 87(3): 1415 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Swensen and E. Marder Modulators with Convergent Cellular Actions Elicit Distinct Circuit Outputs J. Neurosci., June 1, 2001; 21(11): 4050 - 4058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Swensen and E. Marder Multiple Peptides Converge to Activate the Same Voltage-Dependent Current in a Central Pattern-Generating Circuit J. Neurosci., September 15, 2000; 20(18): 6752 - 6759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Duch and R. B. Levine Remodeling of Membrane Properties and Dendritic Architecture Accompanies the Postembryonic Conversion of a Slow into a Fast Motoneuron J. Neurosci., September 15, 2000; 20(18): 6950 - 6961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Baro, A. Ayali, L. French, N. L. Scholz, J. Labenia, C. C. Lanning, K. Graubard, and R. M. Harris-Warrick Molecular Underpinnings of Motor Pattern Generation: Differential Targeting of Shal and Shaker in the Pyloric Motor System J. Neurosci., September 1, 2000; 20(17): 6619 - 6630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. D. Krenz, D. Nguyen, N. L. Perez-Acevedo, and A. I. Selverston Group I, II, and III mGluR Compounds Affect Rhythm Generation in the Gastric Circuit of the Crustacean Stomatogastric Ganglion J Neurophysiol, March 1, 2000; 83(3): 1188 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Birmingham, Z. B. Szuts, L. F. Abbott, and E. Marder Encoding of Muscle Movement on Two Time Scales by a Sensory Neuron That Switches Between Spiking and Bursting Modes J Neurophysiol, November 1, 1999; 82(5): 2786 - 2797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Morisset and F. Nagy Ionic Basis for Plateau Potentials in Deep Dorsal Horn Neurons of the Rat Spinal Cord J. Neurosci., September 1, 1999; 19(17): 7309 - 7316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Cleland and A. I. Selverston Inhibitory Glutamate Receptor Channels in Cultured Lobster Stomatogastric Neurons J Neurophysiol, June 1, 1998; 79(6): 3189 - 3196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Hurley and K. Graubard Pharmacologically and Functionally Distinct Calcium Currents of Stomatogastric Neurons J Neurophysiol, April 1, 1998; 79(4): 2070 - 2081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Booth, J. Rinzel, and O. Kiehn Compartmental Model of Vertebrate Motoneurons for Ca2+-Dependent Spiking and Plateau Potentials Under Pharmacological Treatment J Neurophysiol, December 1, 1997; 78(6): 3371 - 3385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-S. Lo and R. R. Mize Synaptic Regulation of L-Type Ca2+ Channel Activity and Long-Term Depression during Refinement of the Retinocollicular Pathway in Developing Rodent Superior Colliculus J. Neurosci., February 1, 2000; 20(3): RC58 - RC58. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
