|
|
||||||||
Journal of Neurophysiology, Vol 68, Issue 3 945-960, Copyright © 1992 by APS
ARTICLES |
P. Apicella, E. Scarnati, T. Ljungberg and W. Schultz
Institut de Physiologie, Universite de Fribourg, Switzerland.
1. This study investigated neuronal activity in the striatum preceding predictable environmental events and behavioral reactions. Monkeys performed in a delayed go-nogo task that included separate time periods during which animals expected signals of behavioral significance, prepared for execution or inhibition of arm reaching movements, and expected the delivery of reward. In the task, animals were instructed by a green light cue to perform an arm reaching movement when a trigger stimulus came on approximately 3 s later (go situation). Movement was withheld after the same trigger light when the instruction cue had been red (nogo situation). Liquid reward was delivered on correct performance in both situations. 2. A total of 1,173 neurons were studied in the striatum (caudate nucleus and putamen) of 3 animals, of which 615 (52%) showed some change in activity during task performance. This report describes how the activity of 193 task-related neurons increased in advance of at least 1 component of the task, namely the instruction cue, the trigger stimulus, or the delivery of liquid reward. These neurons were found in dorsal and anterior parts of caudate and putamen and were slightly more frequent in the proximity of the internal capsule. 3. The activity of 16 neurons increased in both go and nogo trials before the onset of the instruction and subsided shortly after this signal. These activations may be related to the expectation of the instruction as the first signal in each trial. 4. The activity of 15 neurons increased between the instruction and the trigger stimulus in both go and nogo trials. These activations may be related to the expectation of the trigger stimulus independent of an arm movement. Further 56 neurons showed sustained activations only when the instruction requested a movement reaction. Activations were absent in trials in which the movement was withheld. Twenty-one of these neurons were tested with 2 different movement targets, 5 of which showed activity related to the direction of movement. These activations may be related to the preparation of movement or expectation of the specific movement triggering signal. The activity of an additional 20 neurons was unmodulated before the trigger stimulus in movement trials but increased in the interval between the no-movement instruction and the trigger stimulus for withholding the movement. These activations may be related to the preparation of movement inhibition as specific nogo reaction.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
![]() |
H. Kim, J. H. Sul, N. Huh, D. Lee, and M. W. Jung Role of Striatum in Updating Values of Chosen Actions J. Neurosci., November 25, 2009; 29(47): 14701 - 14712. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. Ford and S. Everling Neural Activity in Primate Caudate Nucleus Associated With Pro- and Antisaccades J Neurophysiol, October 1, 2009; 102(4): 2334 - 2341. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. H. Baeg, M. E. Jackson, H. P. Jedema, and C. W. Bradberry Orbitofrontal and Anterior Cingulate Cortex Neurons Selectively Process Cocaine-Associated Environmental Cues in the Rhesus Monkey J. Neurosci., September 16, 2009; 29(37): 11619 - 11627. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D. Berke, J. T. Breck, and H. Eichenbaum Striatal Versus Hippocampal Representations During Win-Stay Maze Performance J Neurophysiol, March 1, 2009; 101(3): 1575 - 1587. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Joshua, A. Adler, B. Rosin, E. Vaadia, and H. Bergman Encoding of Probabilistic Rewarding and Aversive Events by Pallidal and Nigral Neurons J Neurophysiol, February 1, 2009; 101(2): 758 - 772. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Marklund, A. Larsson, E. Elgh, J. Linder, K. A. Riklund, L. Forsgren, and L. Nyberg Temporal dynamics of basal ganglia under-recruitment in Parkinson's disease: transient caudate abnormalities during updating of working memory Brain, February 1, 2009; 132(2): 336 - 346. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Lau and P. W. Glimcher Action and Outcome Encoding in the Primate Caudate Nucleus J. Neurosci., December 26, 2007; 27(52): 14502 - 14514. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. A. Taha, S. M. Nicola, and H. L. Fields Cue-evoked encoding of movement planning and execution in the rat nucleus accumbens J. Physiol., November 1, 2007; 584(3): 801 - 818. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. A. Teagarden and G. V. Rebec Subthalamic and Striatal Neurons Concurrently Process Motor, Limbic, and Associative Information in Rats Performing an Operant Task J Neurophysiol, March 1, 2007; 97(3): 2042 - 2058. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-C. Dreher, P. Kohn, and K. F. Berman Neural Coding of Distinct Statistical Properties of Reward Information in Humans Cereb Cortex, April 1, 2006; 16(4): 561 - 573. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Watanabe and O. Hikosaka Immediate Changes in Anticipatory Activity of Caudate Neurons Associated With Reversal of Position-Reward Contingency J Neurophysiol, September 1, 2005; 94(3): 1879 - 1887. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.R. Delgado, V.A. Stenger, and J.A. Fiez Motivation-dependent Responses in the Human Caudate Nucleus Cereb Cortex, September 1, 2004; 14(9): 1022 - 1030. [Abstract] [Full Text] [PDF] |
||||
![]() |
S Gauggel, M Rieger, and T-A Feghoff Inhibition of ongoing responses in patients with Parkinson's disease J. Neurol. Neurosurg. Psychiatry, April 1, 2004; 75(4): 539 - 544. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. M. Nicola, I. A. Yun, K. T. Wakabayashi, and H. L. Fields Cue-Evoked Firing of Nucleus Accumbens Neurons Encodes Motivational Significance During a Discriminative Stimulus Task J Neurophysiol, April 1, 2004; 91(4): 1840 - 1865. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Ravel, E. Legallet, and P. Apicella Responses of Tonically Active Neurons in the Monkey Striatum Discriminate between Motivationally Opposing Stimuli J. Neurosci., September 17, 2003; 23(24): 8489 - 8497. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. C. Cromwell and W. Schultz Effects of Expectations for Different Reward Magnitudes on Neuronal Activity in Primate Striatum J Neurophysiol, May 1, 2003; 89(5): 2823 - 2838. [Abstract] [Full Text] [PDF] |
||||
![]() |
E.-I. Izawa, G. Zachar, S. Yanagihara, and T. Matsushima Localized Lesion of Caudal Part of Lobus Parolfactorius Caused Impulsive Choice in the Domestic Chick: Evolutionarily Conserved Function of Ventral Striatum J. Neurosci., March 1, 2003; 23(5): 1894 - 1902. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Kasanetz, L. A Riquelme, and M G. Murer Disruption of the two-state membrane potential of striatal neurones during cortical desynchronisation in anaesthetised rats J. Physiol., September 1, 2002; 543(2): 577 - 589. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Ito, J. W. Dalley, T. W. Robbins, and B. J. Everitt Dopamine Release in the Dorsal Striatum during Cocaine-Seeking Behavior under the Control of a Drug-Associated Cue J. Neurosci., July 15, 2002; 22(14): 6247 - 6253. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Ranaldi and R. A. Wise Blockade of D1 Dopamine Receptors in the Ventral Tegmental Area Decreases Cocaine Reward: Possible Role for Dendritically Released Dopamine J. Neurosci., August 1, 2001; 21(15): 5841 - 5846. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. K. Hassani, H. C. Cromwell, and W. Schultz Influence of Expectation of Different Rewards on Behavior-Related Neuronal Activity in the Striatum J Neurophysiol, June 1, 2001; 85(6): 2477 - 2489. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Hikosaka, Y. Takikawa, and R. Kawagoe Role of the Basal Ganglia in the Control of Purposive Saccadic Eye Movements Physiol Rev, July 1, 2000; 80(3): 953 - 978. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Tremblay and W. Schultz Reward-Related Neuronal Activity During Go-Nogo Task Performance in Primate Orbitofrontal Cortex J Neurophysiol, April 1, 2000; 83(4): 1864 - 1876. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Tremblay and W. Schultz Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Orbitofrontal Cortex J Neurophysiol, April 1, 2000; 83(4): 1877 - 1885. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Schultz, L. Tremblay, and J. R. Hollerman Reward Processing in Primate Orbitofrontal Cortex and Basal Ganglia Cereb Cortex, March 1, 2000; 10(3): 272 - 283. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. D. Alloway, J. Crist, J. J. Mutic, and S. A. Roy Corticostriatal Projections from Rat Barrel Cortex Have an Anisotropic Organization that Correlates with Vibrissal Whisking Behavior J. Neurosci., December 15, 1999; 19(24): 10908 - 10922. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Rodriguez and T. Gonzalez-Hernandez Electrophysiological and Morphological Evidence for a GABAergic Nigrostriatal Pathway J. Neurosci., June 1, 1999; 19(11): 4682 - 4694. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. L. Peoples, F. Gee, R. Bibi, and M. O. West Phasic Firing Time Locked to Cocaine Self-Infusion and Locomotion: Dissociable Firing Patterns of Single Nucleus Accumbens Neurons in the Rat J. Neurosci., September 15, 1998; 18(18): 7588 - 7598. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. R. Hollerman, L. Tremblay, and W. Schultz Influence of Reward Expectation on Behavior-Related Neuronal Activity in Primate Striatum J Neurophysiol, August 1, 1998; 80(2): 947 - 963. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Tremblay, J. R. Hollerman, and W. Schultz Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Striatum J Neurophysiol, August 1, 1998; 80(2): 964 - 977. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Schultz Predictive Reward Signal of Dopamine Neurons J Neurophysiol, July 1, 1998; 80(1): 1 - 27. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Guazzelli, M. Bota, F. J. Corbacho, and M. A. Arbib Affordances. Motivations, and the World Graph Theory Adaptive Behavior, January 1, 1998; 6(3-4): 435 - 471. [Abstract] [PDF] |
||||
![]() |
S. Berretta, H. B. Parthasarathy, and A. M. Graybiel Local Release of GABAergic Inhibition in the Motor Cortex Induces Immediate-Early Gene Expression in Indirect Pathway Neurons of the Striatum J. Neurosci., June 15, 1997; 17(12): 4752 - 4763. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Levy, H. R. Friedman, L. Davachi, and P. S. Goldman-Rakic Differential Activation of the Caudate Nucleus in Primates Performing Spatial and Nonspatial Working Memory Tasks J. Neurosci., May 15, 1997; 17(10): 3870 - 3882. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. L. Peoples and M. O. West Phasic Firing of Single Neurons in the Rat Nucleus Accumbens Correlated with the Timing of Intravenous Cocaine Self-Administration J. Neurosci., May 15, 1996; 16(10): 3459 - 3473. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |