JN Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 68: 978-984, 1992;
0022-3077/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (25)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scharfman, H. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scharfman, H. E.

Journal of Neurophysiology, Vol 68, Issue 3 978-984, Copyright © 1992 by APS

ARTICLES

Blockade of excitation reveals inhibition of dentate spiny hilar neurons recorded in rat hippocampal slices

H. E. Scharfman
Neurology Research Center, Helen Hayes Hospital, New York State Department of Health, West Haverstraw 10993-1195.

1. Extracellular and intracellular recordings in rat hippocampal slices were used to compare the synaptic responses to perforant path stimulation of granule cells of the dentate gyrus, spiny "mossy" cells of the hilus, and area CA3c pyramidal cells of hippocampus. Specifically, we asked whether aspects of the local circuitry could explain the relative vulnerability of spiny hilar neurons to various insults to the hippocampus. 2. Spiny hilar cells demonstrated a surprising lack of inhibition after perforant path activation, despite robust paired-pulse inhibition and inhibitory postsynaptic potentials (IPSPs) in adjacent granule cells and area CA3c pyramidal cells in response to the same stimulus in the same slice. However, when the slice was perfused with excitatory amino acid antagonists [6-cyano-7-nitro-quinoxaline-2,3-dione (CNQX), or CNQX with 2-amino-5-phosphonovaleric acid (APV)], IPSPs could be observed in spiny hilar cells in response to perforant path stimulation. 3. The IPSPs evoked in spiny hilar cells in the presence of CNQX were similar in their reversal potentials and bicuculline sensitivity to IPSPs recorded in dentate granule cells or hippocampal pyramidal cells in the absence of CNQX. 4. These results demonstrate that, at least in slices, perforant path stimulation of spiny hilar cells is primarily excitatory and, when excitation is blocked, underlying inhibition can be revealed. This contrasts to the situation for dentate and hippocampal principal cells, which are ordinarily dominated by inhibition, and only when inhibition is compromised can the full extent of excitation be appreciated.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Physiol.Home page
A. M. Kerr and M. Capogna
Unitary IPSPs enhance hilar mossy cell gain in the rat hippocampus
J. Physiol., January 15, 2007; 578(2): 451 - 470.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Acsady, I. Katona, F. J. Martinez-Guijarro, G. Buzsaki, and T. F. Freund
Unusual Target Selectivity of Perisomatic Inhibitory Cells in the Hilar Region of the Rat Hippocampus
J. Neurosci., September 15, 2000; 20(18): 6907 - 6919.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Z. Shao and A. Burkhalter
Role of GABAB Receptor-Mediated Inhibition in Reciprocal Interareal Pathways of Rat Visual Cortex
J Neurophysiol, March 1, 1999; 81(3): 1014 - 1024.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Shao and A. Burkhalter
Different Balance of Excitation and Inhibition in Forward and Feedback Circuits of Rat Visual Cortex
J. Neurosci., November 15, 1996; 16(22): 7353 - 7365.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online