| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 68, Issue 6 2185-2198, Copyright © 1992 by APS
ARTICLES |
S. M. Lu, W. Guido and S. M. Sherman
Department of Neurobiology, State University of New York, Stony Brook 11794-5230.
1. Thalamic relay cells, including those of the lateral geniculate nucleus, display a low-threshold spike (LT spike), which is a large depolarization due to an increased Ca2+ conductance. Typically riding the crest of each LT spike is a burst of from two to seven action potentials, which we refer to as the LT burst. The LT spike is voltage dependent, because if the cell's resting membrane potential is more depolarized than roughly -60 mV, the LT spike is inactivated, but if more hyperpolarized, the spike is deinactivated and can be activated by a depolarization, such as from an afferent excitatory postsynaptic potential (EPSP). Thalamic relay cells thus display two response modes: a relay or tonic mode, when the cell is depolarized and LT spikes are inactivated, leading to tonic firing of action potentials; and a burst mode, when the cell is hyperpolarized and tends to respond with LT spikes and their associated bursts of action potentials. 2. We were interested in the contribution of the LT spike on the transmission of visually evoked signals through geniculate relay cells to visual cortex. We recorded intracellularly from geniculate cells in an anesthetized, paralyzed, in vivo cat preparation to study the effects of membrane voltage, and thus the presence or absence of LT spikes, on responses to drifting sine-wave gratings. We monitored the visually evoked responses of 14 geniculate neurons (6 X, 7 Y, and 1 unclassified) at different membrane potentials at which LT spikes were inactivated or deinactivated. 3. Changing membrane voltage during visual stimulation switched the response mode of every cell between the relay and burst modes. In the burst mode, LT spikes occurred in phase with the visual stimulus and not at rhythmic intervals uncorrelated to visual stimuli. To any given stimulus cycle, the cell responded usually with an LT burst or a tonic response, and rarely was more than one LT burst evoked by a stimulus cycle. Occasionally a single cycle evoked both an LT burst and tonic response, but always the LT burst occurred first. 4. The spatial tuning characteristics of the cells did not differ dramatically as a function of membrane potential, because the tuning of the LT bursts was quite similar to that of the tonic response component. Although we did not obtain complete temporal tuning properties, we did note that hyperpolarized cells responded reliably with LT bursts at several temporal frequencies. 5. A consistent difference was seen between the LT burst and tonic response components in terms of response linearity.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
|
|
 |
|
  N. Cotillon-Williams, C. Huetz, E. Hennevin, and J.-M. Edeline Tonotopic Control of Auditory Thalamus Frequency Tuning by Reticular Thalamic Neurons J Neurophysiol, March 1, 2008; 99(3): 1137 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Gaudry and P. Reinagel Benefits of Contrast Normalization Demonstrated in Neurons and Model Cells J. Neurosci., July 25, 2007; 27(30): 8071 - 8079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. de Labra, C. Rivadulla, K. Grieve, J. Marino, N. Espinosa, and J. Cudeiro Changes in Visual Responses in the Feline dLGN: Selective Thalamic Suppression Induced by Transcranial Magnetic Stimulation of V1 Cereb Cortex, June 1, 2007; 17(6): 1376 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Lacey, J. P. Bolam, and P. J. Magill Novel and Distinct Operational Principles of Intralaminar Thalamic Neurons and Their Striatal Projections J. Neurosci., April 18, 2007; 27(16): 4374 - 4384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Sincich, D. L. Adams, J. R. Economides, and J. C. Horton Transmission of Spike Trains at the Retinogeniculate Synapse J. Neurosci., March 7, 2007; 27(10): 2683 - 2692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Ruiz, D. Royal, G. Sary, X. Chen, J. D. Schall, and V. A. Casagrande Low-Threshold Ca2+-Associated Bursts Are Rare Events in the LGN of the Awake Behaving Monkey J Neurophysiol, June 1, 2006; 95(6): 3401 - 3413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-I. Lee, S. Ohara, P. M. Dougherty, and F. A. Lenz Pain and Temperature Encoding in the Human Thalamic Somatic Sensory Nucleus (Ventral caudal): Inhibition-Related Bursting Evoked by Somatic Stimuli J Neurophysiol, September 1, 2005; 94(3): 1676 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Ramcharan, J. W. Gnadt, and S. M. Sherman Higher-order thalamic relays burst more than first-order relays PNAS, August 23, 2005; 102(34): 12236 - 12241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Grubb and I. D. Thompson Visual Response Properties of Burst and Tonic Firing in the Mouse Dorsal Lateral Geniculate Nucleus J Neurophysiol, June 1, 2005; 93(6): 3224 - 3247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Denning and P. Reinagel Visual Control of Burst Priming in the Anesthetized Lateral Geniculate Nucleus J. Neurosci., April 6, 2005; 25(14): 3531 - 3538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Lesica and G. B. Stanley Encoding of Natural Scene Movies by Tonic and Burst Spikes in the Lateral Geniculate Nucleus J. Neurosci., November 24, 2004; 24(47): 10731 - 10740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Grubb and I. D. Thompson Visual Response Properties in the Dorsal Lateral Geniculate Nucleus of Mice Lacking the {beta}2 Subunit of the Nicotinic Acetylcholine Receptor J. Neurosci., September 29, 2004; 24(39): 8459 - 8469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. M. Oswald, M. J. Chacron, B. Doiron, J. Bastian, and L. Maler Parallel Processing of Sensory Input by Bursts and Isolated Spikes J. Neurosci., May 5, 2004; 24(18): 4351 - 4362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Massaux, G. Dutrieux, N. Cotillon-Williams, Y. Manunta, and J.-M. Edeline Auditory Thalamus Bursts in Anesthetized and Non-Anesthetized States: Contribution to Functional Properties J Neurophysiol, May 1, 2004; 91(5): 2117 - 2134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kara and R. C. Reid Efficacy of Retinal Spikes in Driving Cortical Responses J. Neurosci., September 17, 2003; 23(24): 8547 - 8557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Eyding, J. D. Macklis, U. Neubacher, K. Funke, and F. Worgotter Selective Elimination of Corticogeniculate Feedback Abolishes the Electroencephalogram Dependence of Primary Visual Cortical Receptive Fields and Reduces Their Spatial Specificity J. Neurosci., August 6, 2003; 23(18): 7021 - 7033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cotillon-Williams and J.-M. Edeline Evoked Oscillations in the Thalamo-Cortical Auditory System Are Present in Anesthetized but not in Unanesthetized Rats J Neurophysiol, April 1, 2003; 89(4): 1968 - 1984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Uhlrich, K. A. Manning, and J.-T. Xue Effects of Activation of the Histaminergic Tuberomammillary Nucleus on Visual Responses of Neurons in the Dorsal Lateral Geniculate Nucleus J. Neurosci., February 1, 2002; 22(3): 1098 - 1107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Weyand, M. Boudreaux, and W. Guido Burst and Tonic Response Modes in Thalamic Neurons During Sleep and Wakefulness J Neurophysiol, March 1, 2001; 85(3): 1107 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Hillenbrand and J. L. van Hemmen Does Corticothalamic Feedback Control Cortical Velocity Tuning? Neural Comput., February 1, 2001; 13(2): 327 - 355. [Abstract] [Full Text]
|
|
|
|
|
|
E. J. Ramcharan, C. L. Cox, X. J. Zhan, S. M. Sherman, and J. W. Gnadt Cellular Mechanisms Underlying Activity Patterns in the Monkey Thalamus During Visual Behavior J Neurophysiol, October 1, 2000; 84(4): 1982 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Edeline, Y. Manunta, and E. Hennevin Auditory Thalamus Neurons During Sleep: Changes in Frequency Selectivity, Threshold, and Receptive Field Size J Neurophysiol, August 1, 2000; 84(2): 934 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Reinagel and R. C. Reid Temporal Coding of Visual Information in the Thalamus J. Neurosci., July 15, 2000; 20(14): 5392 - 5400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Usrey, J. B. Reppas, and R. C. Reid Specificity and Strength of Retinogeniculate Connections J Neurophysiol, December 1, 1999; 82(6): 3527 - 3540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Reinagel, D. Godwin, S. M. Sherman, and C. Koch Encoding of Visual Information by LGN Bursts J Neurophysiol, May 1, 1999; 81(5): 2558 - 2569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Zhu and F.-S. Lo Control of Recurrent Inhibition of the Lateral Posterior-Pulvinar Complex by Afferents from the Deep Layers of the Superior Colliculus of the Rabbit J Neurophysiol, September 1, 1998; 80(3): 1122 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lee and J. G. Malpeli Effects of Saccades on the Activity of Neurons in the Cat Lateral Geniculate Nucleus J Neurophysiol, February 1, 1998; 79(2): 922 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Debusk, E. J. Debruyn, R. K. Snider, J. F. Kabara, and A. B. Bonds Stimulus-Dependent Modulation of Spike Burst Length in Cat Striate Cortical Cells J Neurophysiol, July 1, 1997; 78(1): 199 - 213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhou, D. W. Godwin, D. M. O'Malley, and P. R. Adams Visualization of Calcium Influx Through Channels That Shape the Burst and Tonic Firing Modes of Thalamic Relay Cells J Neurophysiol, May 1, 1997; 77(5): 2816 - 2825. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
