JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 69: 57-73, 1993;
0022-3077/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Kan, P. L.
Right arrow Articles by Gibson, A. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Kan, P. L.
Right arrow Articles by Gibson, A. R.

Journal of Neurophysiology, Vol 69, Issue 1 57-73, Copyright © 1993 by APS

ARTICLES

Output organization of intermediate cerebellum of the monkey

P. L. van Kan, J. C. Houk and A. R. Gibson
Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611.

1. The goal of this study was to investigate the motor organization of monkey nucleus interpositus (NI) and neighboring regions of the lateral nucleus (NL) by correlating discharge of single neurons with active movements. Neurons were surveyed during free-form movements as well as during operation of six devices that required movement about specific forelimb joints. The paradigm allowed us to test the hypothesis that discharge of individual cells relates to movements about individual joints. 2. One hundred sixty-two isolated nuclear neurons from two monkeys were studied. Eighty-three percent showed large increases in discharge (an average of 3 times resting rate for forelimb neurons) during movement of one body part, either forelimb, hindlimb, mouth/face, or eyes. 3. Anterior interpositus contains neurons related to hindlimb movement in anterior regions and neurons related to forelimb movement in posterior regions. A mouth/face-related area exists in the dorsal-posterior regions and is continuous with a mouth/face area in the dorsal regions of NL. Posterior interpositus (NIP) showed no clear separation between forelimb and hindlimb neurons: forelimb neurons were encountered throughout the nucleus, and hindlimb neurons were encountered in the medial-anterior two thirds. A distinct eye movement area exists in lateral, posterior, and ventral regions of NIP. This area borders regions of NL that also contain eye movement-related neurons. 4. Forelimb interpositus neurons discharged strongly during reach and grasp; discharge rates were recorded for 41 neurons during a stereotyped reach and the average depth of modulation was 149 imp/s. Nineteen neurons that modulated during device tracking were also tested during reaching, and the depth of modulation was much greater during reaching. 5. Fifty-nine forelimb neurons were tested with device tracking. Twenty-seven (46%) produced no audible modulation, regardless of the joint being exercised. The remaining 32 neurons modulated during movement on at least one device (mean depth of modulation = 84 imp/s). Comparison of discharge during use of different devices revealed no strong evidence for device-specific discharge. 6. Discharge modulations during device tracking were phasic, preceded movement, and, for a small number of cells, showed consistent parametric relations to duration, amplitude, and velocity of movement. 7. Despite a clear somatotopy within NI and NL, there is no finer mapping based on active movements about individual joints within forelimb regions. Discharge modulation depends on movements involving the whole limb. Progress in understanding the function of intermediate cerebellum depends on determining the variables required to elicit consistent and high modulation of neural discharge.(ABSTRACT TRUNCATED AT 400 WORDS)


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
N. C. Rowland and D. Jaeger
Responses to Tactile Stimulation in Deep Cerebellar Nucleus Neurons Result From Recurrent Activation in Multiple Pathways
J Neurophysiol, February 1, 2008; 99(2): 704 - 717.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Sanchez-Campusano, A. Gruart, and J. M. Delgado-Garcia
The Cerebellar Interpositus Nucleus and the Dynamic Control of Learned Motor Responses
J. Neurosci., June 20, 2007; 27(25): 6620 - 6632.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Herzog, W. Hamel, R. Wenzelburger, M. Potter, M. O. Pinsker, J. Bartussek, A. Morsnowski, F. Steigerwald, G. Deuschl, and J. Volkmann
Kinematic analysis of thalamic versus subthalamic neurostimulation in postural and intention tremor
Brain, June 1, 2007; 130(6): 1608 - 1625.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. R. Townsend, L. Paninski, and R. N. Lemon
Linear Encoding of Muscle Activity in Primary Motor Cortex and Cerebellum
J Neurophysiol, November 1, 2006; 96(5): 2578 - 2592.
[Abstract] [Full Text] [PDF]

Home page
 J. Cogn. Neurosci.Home page
F. Magescas and C. Prablanc
Automatic Drive of Limb Motor Plasticity
J. Cogn. Neurosci., January 1, 2006; 18(1): 75 - 83.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. R. Mason, C. M. Hendrix, and T. J. Ebner
Purkinje Cells Signal Hand Shape and Grasp Force During Reach-to-Grasp in the Monkey
J Neurophysiol, January 1, 2006; 95(1): 144 - 158.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Jimenez-Diaz, J. de Dios Navarro-Lopez, A. Gruart, and J. M. Delgado-Garcia
Role of Cerebellar Interpositus Nucleus in the Genesis and Control of Reflex and Conditioned Eyelid Responses
J. Neurosci., October 13, 2004; 24(41): 9138 - 9145.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. B. Debicki and P. L. Gribble
Inter-Joint Coupling Strategy During Adaptation to Novel Viscous Loads in Human Arm Movement
J Neurophysiol, August 1, 2004; 92(2): 754 - 765.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
X. Liu, E. Robertson, and R. C. Miall
Neuronal Activity Related to the Visual Representation of Arm Movements in the Lateral Cerebellar Cortex
J Neurophysiol, March 1, 2003; 89(3): 1223 - 1237.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. P. Goodkin and W. T. Thach
Cerebellar Control of Constrained and Unconstrained Movements. II. EMG and Nuclear Activity
J Neurophysiol, February 1, 2003; 89(2): 896 - 908.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
R. P. DUM, C. LI, and P. L. STRICK
Motor and Nonmotor Domains in the Monkey Dentate
Ann. N.Y. Acad. Sci., December 1, 2002; 978(1): 289 - 301.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. L. E. Van Kan and M. L. McCurdy
Contribution of Primate Magnocellular Red Nucleus to Timing of Hand Preshaping During Reaching to Grasp
J Neurophysiol, March 1, 2002; 87(3): 1473 - 1487.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. M. Clower, R. A. West, J. C. Lynch, and P. L. Strick
The Inferior Parietal Lobule Is the Target of Output from the Superior Colliculus, Hippocampus, and Cerebellum
J. Neurosci., August 15, 2001; 21(16): 6283 - 6291.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. L. E. Van Kan and M. L. McCurdy
Role of Primate Magnocellular Red Nucleus Neurons in Controlling Hand Preshaping During Reaching to Grasp
J Neurophysiol, April 1, 2001; 85(4): 1461 - 1478.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. M. Earhart and A. J. Bastian
Selection and Coordination of Human Locomotor Forms Following Cerebellar Damage
J Neurophysiol, February 1, 2001; 85(2): 759 - 769.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Gruart, G. Guillazo-Blanch, R. Fernandez-Mas, L. Jimenez-Diaz, and J. M. Delgado-Garcia
Cerebellar Posterior Interpositus Nucleus as an Enhancer of Classically Conditioned Eyelid Responses in Alert Cats
J Neurophysiol, November 1, 2000; 84(5): 2680 - 2690.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. R. Robinson
Role of the Cerebellar Posterior Interpositus Nucleus in Saccades I. Effect of Temporary Lesions
J Neurophysiol, September 1, 2000; 84(3): 1289 - 1302.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. L. Gribble and D. J. Ostry
Compensation for Interaction Torques During Single- and Multijoint Limb Movement
J Neurophysiol, November 1, 1999; 82(5): 2310 - 2326.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. D. Coltz, M. T. V. Johnson, and T. J. Ebner
Cerebellar Purkinje Cell Simple Spike Discharge Encodes Movement Velocity in Primates during Visuomotor Arm Tracking
J. Neurosci., March 1, 1999; 19(5): 1782 - 1803.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. E. Hoover and P. L. Strick
The Organization of Cerebellar and Basal Ganglia Outputs to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Herpes Simplex Virus Type 1
J. Neurosci., February 15, 1999; 19(4): 1446 - 1463.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Zhang and P. D. R. Gamlin
Neurons in the Posterior Interposed Nucleus of the Cerebellum Related to Vergence and Accommodation. I. Steady-State Characteristics
J Neurophysiol, March 1, 1998; 79(3): 1255 - 1269.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. R. Mason, L. E. Miller, J. F. Baker, and J. C. Houk
Organization of Reaching and Grasping Movements in the Primate Cerebellar Nuclei as Revealed by Focal Muscimol Inactivations
J Neurophysiol, February 1, 1998; 79(2): 537 - 554.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. E. Desmond, J. D. E. Gabrieli, A. D. Wagner, B. L. Ginier, and G. H. Glover
Lobular Patterns of Cerebellar Activation in Verbal Working-Memory and Finger-Tapping Tasks as Revealed by Functional MRI
J. Neurosci., December 15, 1997; 17(24): 9675 - 9685.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. R. Robinson, A. Straube, and A. F. Fuchs
Participation of Caudal Fastigial Nucleus in Smooth Pursuit Eye Movements. II. Effects of Muscimol Inactivation
J Neurophysiol, August 1, 1997; 78(2): 848 - 859.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. S. Milak, Y. Shimansky, V. Bracha, and J. R. Bloedel
Effects of Inactivating Individual Cerebellar Nuclei on the Performance and Retention of an Operantly Conditioned Forelimb Movement
J Neurophysiol, August 1, 1997; 78(2): 939 - 959.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Q.-G. Fu, D. Flament, J. D. Coltz, and T. J. Ebner
Relationship of Cerebellar Purkinje Cell Simple Spike Discharge to Movement Kinematics in the Monkey
J Neurophysiol, July 1, 1997; 78(1): 478 - 491.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Kitazawa, T. Kimura, and T. Uka
Prism Adaptation of Reaching Movements: Specificity for the Velocity of Reaching
J. Neurosci., February 15, 1997; 17(4): 1481 - 1492.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
L M Parsons, J M Bower, J H Gao, J Xiong, J Li, and P T Fox
Lateral cerebellar hemispheres actively support sensory acquisition and discrimination rather than motor control.
Learn. Mem., January 1, 1997; 4(1): 49 - 62.
[Abstract] [PDF]

Home page
 ScienceHome page
F. Middleton and P. Strick
Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function
Science, October 21, 1994; 266(5184): 458 - 461.
[Abstract] [PDF]

Home page
 ScienceHome page
S. Kim, K Ugurbil, and P. Strick
Activation of a cerebellar output nucleus during cognitive processing
Science, August 12, 1994; 265(5174): 949 - 951.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online