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Journal of Neurophysiology, Vol 69, Issue 3 992-995, Copyright © 1993 by APS
ARTICLES |
A. A. Sharp, M. B. O'Neil, L. F. Abbott and E. Marder
Department of Biology, Brandeis University, Waltham, Massachusetts 02254.
1. We describe a new method, the dynamic clamp, that uses a computer as an interactive tool to introduce simulated voltage and ligand mediated conductances into real neurons. 2. We simulate a gamma-aminobutyric acid (GABA) response of a cultured stomatogastric ganglion neuron to illustrate that the dynamic clamp effectively introduces a conductance into the target neuron. 3. To demonstrate an artificial voltage-dependent conductance, we simulate the action of a voltage-dependent proctolin response on a neuron in the intact stomatogastric ganglion. We show that shifts in the activation curve and the maximal conductance of the response produce different effects on the target neuron. 4. The dynamic clamp is used to construct reciprocal inhibitory synapses between two stomatogastric ganglion neurons that are not coupled naturally, illustrating that this method can be used to form new networks at will.
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 A. SELVERSTON, R. ELSON, M. RABINOVICH, R. HUERTA, and H. ABARBANEL Basic Principles for Generating Motor Output in the Stomatogastric Ganglion Ann. N.Y. Acad. Sci., November 16, 1998; 860(1): 35 - 50. [Abstract] [Full Text] [PDF]
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E. MARDER, Y. MANOR, F. NADIM, M. BARTOS, and M. P. NUSBAUM Frequency Control of a Slow Oscillatory Network by a Fast Rhythmic Input: Pyloric to Gastric Mill Interactions in the Crab Stomatogastric Nervous System Ann. N.Y. Acad. Sci., November 16, 1998; 860(1): 226 - 238. [Abstract] [Full Text] [PDF]
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D. Ulrich and J. R. Huguenard gamma -Aminobutyric acid type B receptor-dependent burst-firing in thalamic neurons: A dynamic clamp study PNAS, November 12, 1996; 93(23): 13245 - 13249. [Abstract] [Full Text] [PDF]
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