| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 69, Issue 4 1245-1263, Copyright © 1993 by APS
ARTICLES |
M. W. Spitzer and M. N. Semple
Department of Anatomy and Neurobiology, University of California, Irvine 92717.
1. Motion of sound sources results in temporal variation of the binaural cues for sound localization. We evaluated the influence of virtual motion on neural tuning to one of these cues, interaural phase disparity (IPD). Responses to dichotic stimuli were recorded from single units in the inferior colliculus of the anesthetized cat and gerbil (Meriones unguiculatus). Static IPDs were generated by presenting dichotic tone pairs with a constant phase offset maintained for the duration of the stimulus. Time-varying IPDs were generated by simultaneously presenting a pure tone to one ear and a phase-modulated tone to the other ear. Sets of time-varying stimuli consisted of modulations through partially overlapping ranges of IPD, corresponding to movement of a sound source through partially overlapping arcs in the horizontal plane. 2. In agreement with previous results, neuronal discharge was typically a peaked function of static IPD resulting from both binaural facilitation at favorable IPDs and binaural suppression at unfavorable IPDs. Responses to time-varying IPD stimuli appeared to be shaped by the same facilitative and inhibitory mechanisms that underlie static IPD tuning. Modulation toward the peak of binaural facilitation increased the probability of discharge, and modulation toward the peak of binaural suppression decreased the probability of discharge. However, it was also clear that IPD tuning could be significantly altered by the temporal context of the stimulus. For the vast majority of units in response to modulation through partially overlapping ranges of IPD the discharge rate profiles were generally nonoverlapping. This shift in IPD tuning induced by the virtual motion reflects the fact that the binaural interaction associated with a given IPD depends on the recent history of stimulation. In addition, modulation in opposite directions through the same range of IPDs often elicited asymmetric responses. These nonlinearities imply that most inferior colliculus neurons do not unambiguously encode a specific IPD, but instead may encode small changes of IPD occurring virtually anywhere within their receptive fields. In a few cases modulation through overlapping ranges of IPD elicited contiguous response profiles, indicating that for these units responses were determined entirely by instantaneous IPD. 3. The nonlinearity of responses to time-varying IPD stimuli could not be attributed to monaural entrainment to the phase-modulated signals, did not depend on the phase modulation waveform, and occurred irrespective of which ear received the phase-modulated signal. Responses were similar in cats and gerbils, suggesting that the underlying mechanisms are common to binaural processing in diverse mammalian species.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
|
|
 |
|
  I. Siveke, S. D. Ewert, B. Grothe, and L. Wiegrebe Psychophysical and Physiological Evidence for Fast Binaural Processing J. Neurosci., February 27, 2008; 28(9): 2043 - 2052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xu, V. C. Kotak, and D. H. Sanes Conductive Hearing Loss Disrupts Synaptic and Spike Adaptation in Developing Auditory Cortex J. Neurosci., August 29, 2007; 27(35): 9417 - 9426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ter-Mikaelian, D. H. Sanes, and M. N. Semple Transformation of Temporal Properties between Auditory Midbrain and Cortex in the Awake Mongolian Gerbil J. Neurosci., June 6, 2007; 27(23): 6091 - 6102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. X. Joris, B. van de Sande, A. Recio-Spinoso, and M. van der Heijden Auditory Midbrain and Nerve Responses to Sinusoidal Variations in Interaural Correlation J. Neurosci., January 4, 2006; 26(1): 279 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Lane and B. Delgutte Neural Correlates and Mechanisms of Spatial Release From Masking: Single-Unit and Population Responses in the Inferior Colliculus J Neurophysiol, August 1, 2005; 94(2): 1180 - 1198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Furukawa, K. Maki, M. Kashino, and H. Riquimaroux Dependency of the Interaural Phase Difference Sensitivities of Inferior Collicular Neurons on a Preceding Tone and Its Implications in Neural Population Coding J Neurophysiol, June 1, 2005; 93(6): 3313 - 3326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Shackleton, B. C. Skottun, R. H. Arnott, and A. R. Palmer Interaural Time Difference Discrimination Thresholds for Single Neurons in the Inferior Colliculus of Guinea Pigs J. Neurosci., January 15, 2003; 23(2): 716 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ramachandran and B. J. May Functional Segregation of ITD Sensitivity in the Inferior Colliculus of Decerebrate Cats J Neurophysiol, November 1, 2002; 88(5): 2251 - 2261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Borisyuk, M. N. Semple, and J. Rinzel Adaptation and Inhibition Underlie Responses to Time-Varying Interaural Phase Cues in a Model of Inferior Colliculus Neurons J Neurophysiol, October 1, 2002; 88(4): 2134 - 2146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Behrend, A. Brand, C. Kapfer, and B. Grothe Auditory Response Properties in the Superior Paraolivary Nucleus of the Gerbil J Neurophysiol, June 1, 2002; 87(6): 2915 - 2928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Malone, B. H. Scott, and M. N. Semple Context-Dependent Adaptive Coding of Interaural Phase Disparity in the Auditory Cortex of Awake Macaques J. Neurosci., June 1, 2002; 22(11): 4625 - 4638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. McAlpine and A. R. Palmer Blocking GABAergic Inhibition Increases Sensitivity to Sound Motion Cues in the Inferior Colliculus J. Neurosci., February 15, 2002; 22(4): 1443 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Malone and M. N. Semple Effects of Auditory Stimulus Context on the Representation of Frequency in the Gerbil Inferior Colliculus J Neurophysiol, September 1, 2001; 86(3): 1113 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Burger and G. D. Pollak Reversible Inactivation of the Dorsal Nucleus of the Lateral Lemniscus Reveals Its Role in the Processing of Multiple Sound Sources in the Inferior Colliculus of Bats J. Neurosci., July 1, 2001; 21(13): 4830 - 4843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Ingham, H. C. Hart, and D. McAlpine Spatial Receptive Fields of Inferior Colliculus Neurons to Auditory Apparent Motion in Free Field J Neurophysiol, January 1, 2001; 85(1): 23 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. McAlpine, D. Jiang, T. M. Shackleton, and A. R. Palmer Responses of Neurons in the Inferior Colliculus to Dynamic Interaural Phase Cues: Evidence for a Mechanism of Binaural Adaptation J Neurophysiol, March 1, 2000; 83(3): 1356 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Kelly and S. A. Kidd NMDA and AMPA Receptors in the Dorsal Nucleus of the Lateral Lemniscus Shape Binaural Responses in Rat Inferior Colliculus J Neurophysiol, March 1, 2000; 83(3): 1403 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Davis, R. Ramachandran, and B. J. May Single-Unit Responses in the Inferior Colliculus of Decerebrate Cats II. Sensitivity to Interaural Level Differences J Neurophysiol, July 1, 1999; 82(1): 164 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Doan and J. C. Saunders Sensitivity to Simulated Directional Sound Motion in the Rat Primary Auditory Cortex J Neurophysiol, May 1, 1999; 81(5): 2075 - 2087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Spitzer and M. N. Semple Transformation of Binaural Response Properties in the Ascending Auditory Pathway: Influence of Time-Varying Interaural Phase Disparity J Neurophysiol, December 1, 1998; 80(6): 3062 - 3076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Moore, V. C. Kotak, and D. H. Sanes Commissural and Lemniscal Synaptic Input to the Gerbil Inferior Colliculus J Neurophysiol, November 1, 1998; 80(5): 2229 - 2236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. McAlpine, D. Jiang, T. M. Shackleton, and A. R. Palmer Convergent Input from Brainstem Coincidence Detectors onto Delay-Sensitive Neurons in the Inferior Colliculus J. Neurosci., August 1, 1998; 18(15): 6026 - 6039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. W. Wilson and W. E. O'Neill Auditory Motion Induces Directionally Dependent Receptive Field Shifts in Inferior Colliculus Neurons J Neurophysiol, April 1, 1998; 79(4): 2040 - 2062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Sanes, B. J. Malone, and M. N. Semple Role of Synaptic Inhibition in Processing of Dynamic Binaural Level Stimuli J. Neurosci., January 15, 1998; 18(2): 794 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. He, T. Hashikawa, H. Ojima, and Y. Kinouchi Temporal Integration and Duration Tuning in the Dorsal Zone of Cat Auditory Cortex J. Neurosci., April 1, 1997; 17(7): 2615 - 2625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Skottun, T. M. Shackleton, R. H. Arnott, and A. R. Palmer The ability of inferior colliculus neurons to signal differences in interaural delay PNAS, November 20, 2001; 98(24): 14050 - 14054. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
