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Journal of Neurophysiology, Vol 70, Issue 2 828-843, Copyright © 1993 by APS
ARTICLES |
K. E. Cullen and R. A. McCrea
Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637.
1. The single-unit activity of vestibular neurons was recorded in alert squirrel monkeys. The monkeys had been trained to track a small visual target by generating smooth pursuit eye movements and to cancel their vestibuloocular reflex (VOR) by fixating a head stationary target. The monkeys were seated on a vestibular turntable, and their heads were held in the plane of the horizontal semicircular canals. The responses of 45 type I vestibular neurons whose activity was related to ipsilateral horizontal head movements were recorded. In 19 of 30 cells tested, electrical stimulation (0.1-ms monophasic pulses, < or = 800 microA) of the ipsilateral vestibular nerve evoked a spike at a monosynaptic latency (0.7-1.3 ms). 2. The spiking behavior of each cell was recorded during several behavioral paradigms: 1) spontaneous eye movements, 2) horizontal smooth pursuit of a target that was moved sinusoidally +/- 20 degrees/s at 0.5 Hz, 3) horizontal VOR during 0.5-Hz sinusoidal turntable rotations +/- 40 degrees/s (VORs), and 4) voluntary cancellation of the sinusoidal VOR by fixation of a head-stationary target during 0.5-Hz sinusoidal turntable rotation at +/- 40 degrees/s in the light (VORCs). 3. The response of most (34) of the units was recorded during unpredictable 100-ms steps in head acceleration (400 degrees/s2) that were generated while the monkey was fixating a target light. The acceleration steps were generated either when the monkey was stationary (VORt paradigm) or when the turntable was already rotating, and the monkey was canceling its VOR (VORCt paradigm). Smaller eye movements were evoked when the acceleration step was generated during VOR cancellation. 4. Type I vestibular units were grouped into two classes on the basis of the relationship of their firing rate to eye movements. The discharge rate of 20 "pure vestibular" units was not clearly related to eye movements. The remaining 25 units were classified as position-vestibular-pause (PVP) neurons. PVP neurons increased their firing rate during contralateral eye movements and during ipsilateral turntable rotations, and paused during saccadic eye movements. 5. Most (17/20) pure vestibular neurons generated the same response to vestibular stimuli when the monkeys canceled their VOR as they did during the VOR in both the sinusoidal and acceleration step paradigms. 6. The head velocity sensitivity of most (19/24) PVP neurons was reduced by 20-60% during VORCs, compared with their response during the VORs. The PVP neurons whose sensitivity of head movements was reduced during VORCs also exhibited a reduced vestibular sensitivity during VORCt.(ABSTRACT TRUNCATED AT 400 WORDS)
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K. E. Cullen, M. Huterer, D. A. Braidwood, and P. A. Sylvestre Time Course of Vestibuloocular Reflex Suppression During Gaze Shifts J Neurophysiol, December 1, 2004; 92(6): 3408 - 3422. [Abstract] [Full Text] [PDF]
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G. R. Barnes and G. D. Paige Anticipatory VOR Suppression Induced by Visual and Nonvisual Stimuli in Humans J Neurophysiol, September 1, 2004; 92(3): 1501 - 1511. [Abstract] [Full Text] [PDF]
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D. E. Angelaki Eyes on Target: What Neurons Must do for the Vestibuloocular Reflex During Linear Motion J Neurophysiol, July 1, 2004; 92(1): 20 - 35. [Abstract] [Full Text] [PDF]
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K. E. Cullen and J. E. Roy Signal Processing in the Vestibular System During Active Versus Passive Head Movements J Neurophysiol, May 1, 2004; 91(5): 1919 - 1933. [Abstract] [Full Text] [PDF]
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 J. E. Roy and K. E. Cullen Dissociating Self-Generated from Passively Applied Head Motion: Neural Mechanisms in the Vestibular Nuclei J. Neurosci., March 3, 2004; 24(9): 2102 - 2111. [Abstract] [Full Text] [PDF]
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P. A. Sylvestre, J. T. L. Choi, and K. E. Cullen Discharge Dynamics of Oculomotor Neural Integrator Neurons During Conjugate and Disjunctive Saccades and Fixation J Neurophysiol, August 1, 2003; 90(2): 739 - 754. [Abstract] [Full Text] [PDF]
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D. E. Angelaki and J. D. Dickman Premotor Neurons Encode Torsional Eye Velocity during Smooth-Pursuit Eye Movements J. Neurosci., April 1, 2003; 23(7): 2971 - 2979. [Abstract] [Full Text] [PDF]
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J. D. Dickman and D. E. Angelaki Vestibular Convergence Patterns in Vestibular Nuclei Neurons of Alert Primates J Neurophysiol, December 1, 2002; 88(6): 3518 - 3533. [Abstract] [Full Text] [PDF]
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J. E. Roy and K. E. Cullen Vestibuloocular Reflex Signal Modulation During Voluntary and Passive Head Movements J Neurophysiol, May 1, 2002; 87(5): 2337 - 2357. [Abstract] [Full Text] [PDF]
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P. A. Sylvestre, H. L. Galiana, and K. E. Cullen Conjugate and Vergence Oscillations During Saccades and Gaze Shifts: Implications for Integrated Control of Binocular Movement J Neurophysiol, January 1, 2002; 87(1): 257 - 272. [Abstract] [Full Text] [PDF]
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D. E. Angelaki, A. M. Green, and J. D. Dickman Differential Sensorimotor Processing of Vestibulo-Ocular Signals during Rotation and Translation J. Neurosci., June 1, 2001; 21(11): 3968 - 3985. [Abstract] [Full Text] [PDF]
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J. E. Roy and K. E. Cullen Selective Processing of Vestibular Reafference during Self-Generated Head Motion J. Neurosci., March 15, 2001; 21(6): 2131 - 2142. [Abstract] [Full Text] [PDF]
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T. Belton and R. A. McCrea Role of the Cerebellar Flocculus Region in Cancellation of the VOR During Passive Whole Body Rotation J Neurophysiol, September 1, 2000; 84(3): 1599 - 1613. [Abstract] [Full Text] [PDF]
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G. T. Gdowski and R. A. McCrea Integration of Vestibular and Head Movement Signals in the Vestibular Nuclei During Whole-Body Rotation J Neurophysiol, July 1, 1999; 82(1): 436 - 449. [Abstract] [Full Text] [PDF]
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K. V. Shenoy, D. C. Bradley, and R. A. Andersen Influence of Gaze Rotation on the Visual Response of Primate MSTd Neurons J Neurophysiol, June 1, 1999; 81(6): 2764 - 2786. [Abstract] [Full Text] [PDF]
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C. Chen-Huang and R. A. McCrea Effects of Viewing Distance on the Responses of Horizontal Canal-Related Secondary Vestibular Neurons During Angular Head Rotation J Neurophysiol, May 1, 1999; 81(5): 2517 - 2537. [Abstract] [Full Text] [PDF]
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C. Chen-Huang and R. A. McCrea Effects of Viewing Distance on the Responses of Vestibular Neurons to Combined Angular and Linear Vestibular Stimulation J Neurophysiol, May 1, 1999; 81(5): 2538 - 2557. [Abstract] [Full Text] [PDF]
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A. M. Green and H. L. Galiana Hypothesis for Shared Central Processing of Canal and Otolith Signals J Neurophysiol, October 1, 1998; 80(4): 2222 - 2228. [Abstract] [Full Text] [PDF]
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K. E. Cullen and D. Guitton Analysis of Primate IBN Spike Trains Using System Identification Techniques. I. Relationship to Eye Movement Dynamics During Head-Fixed Saccades J Neurophysiol, December 1, 1997; 78(6): 3259 - 3282. [Abstract] [Full Text] [PDF]
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