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J Neurophysiol 70: 1316-1325, 1993;
0022-3077/93 $5.00
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Journal of Neurophysiology, Vol 70, Issue 4 1316-1325, Copyright © 1993 by APS

ARTICLES

Spatial distribution of excitatory and inhibitory synapses on a Purkinje cell in a rat cerebellar culture

T. Hirano and K. Kasono
Department of Physiology, Faculty of Medicine, Kyoto University, Japan.

1. The spatial distribution of excitatory and inhibitory synapses on cultured Purkinje cells was studied with fluorescence, scanning electron microscopy (SEM), and electrophysiological techniques. 2. Presynaptic terminals were identified with immunohistochemical staining of synaptophysin and the results were correlated with SEM micrographs. 3. Excitatory and inhibitory inputs onto the Purkinje cell were identified from the direction and pharmacology of the postsynaptic current. 4. The localization of the presynaptic terminals on the Purkinje cell was observed after electrophysiological identification by filling the presynaptic neuron with Lucifer yellow and the Purkinje cell with Texas red. 5. The axon and presynaptic terminals of excitatory and inhibitory inputs had a different spatial organization. Excitatory inputs from granule cells were exclusively localized on the dendrites of Purkinje cells, whereas inhibitory contacts were found on both the soma and dendrites. This result is similar to that described in vivo.


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