JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 70: 1822-1826, 1993;
0022-3077/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Horii, A.
Right arrow Articles by Wada, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Horii, A.
Right arrow Articles by Wada, H.

Journal of Neurophysiology, Vol 70, Issue 5 1822-1826, Copyright © 1993 by APS

ARTICLES

Effect of unilateral vestibular stimulation on histamine release from the hypothalamus of rats in vivo

A. Horii, N. Takeda, T. Matsunaga, A. Yamatodani, T. Mochizuki, K. Okakura-Mochizuki and H. Wada
Department of Otolaryngology, Osaka University Medical School, Suita, Japan.

1. We investigated the effect of unilateral vestibular stimulation on histamine release from the anterior hypothalamic area of urethan-anesthetized rats in vivo, using a brain microdialysis method coupled with high-performance liquid chromatography fluorometry. 2. The histamine release was increased to approximately 180% of the basal release by the electrical stimulation of the inner ear with 1 Hz, 500 microA, and 200 ms for 20 min. This effect was dependent on the current intensity. 3. Activation of the unilateral horizontal semicircular canal by middle ear irrigation for 15 min with 45 degrees C water increased the histamine release to approximately 200% of the basal release. 4. Irrigation of the middle ear with ice water for 15 min increased the histamine release to approximately 190% of the basal release. 5. The histamine release was not changed by the irrigation of the middle ear with 37 degrees C water and the irrigation of the auricle with ice water, which suggests that neither somatosensory stimulation to the middle ear nor nonspecific cold stress affects the histamine release. 6. All these findings suggest that the sensory mismatch signals induced by caloric stimulation and unilateral electrical vestibular stimulation activate the histaminergic neuron system in the brain.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
H. L. Haas, O. A. Sergeeva, and O. Selbach
Histamine in the Nervous System
Physiol Rev, July 1, 2008; 88(3): 1183 - 1241.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F. Bergquist, A. Ruthven, M. Ludwig, and M. B. Dutia
Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats
J. Physiol., December 15, 2006; 577(3): 857 - 868.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Tighilet, S. Trottier, C. Mourre, and M. Lacour
Changes in the histaminergic system during vestibular compensation in the cat
J. Physiol., June 15, 2006; 573(3): 723 - 739.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online