Journal of Neurophysiology, Vol 70, Issue 6 2660-2664, Copyright © 1993 by APS

ARTICLES

Preferential activity of dentate neurons during limb movements guided by vision

H. Mushiake and P. L. Strick
Department of Neurosurgery, State University of New York Health Science Center at Syracuse 13210.

1. We recorded the activity of dentate neurons while monkeys (n = 2) performed sequential pointing movements under two task conditions: visually guided and remembered. For both conditions, a monkey faced a panel with five touch pads. The animal began a trial by placing his right hand on a hold key in front of him. In the Remembered Sequence Task, light-emitting diodes (LEDs) over three touch pads were illuminated in a sequence as an instruction to the monkey. At the end of a variable instruction period, an auditory "Go" signal told the monkey to release the hold key and press the touch pads according to the instructed sequence. In the Tracking Task, the monkey was required to press three touch pads immediately after the LED over each of them was illuminated. 2. We recorded from 172 neurons in the dentate that showed task-related changes in activity during the reaction time (RT) period (i.e., the interval between the onset of the Go signal and the release of the hold key). Approximately 40% of these neurons were considered task-dependent because they displayed exclusive or enhanced (> +/- 50%) changes in peak activity during the RT period for one of the two task conditions. Almost 80% of the task-dependent neurons displayed exclusive or enhanced activity changes during the Tracking Task. Many of these neurons were located ventral and lateral to dentate neurons, which were not task-dependent. 3. These results suggest that a portion of the dentate nucleus is preferentially involved in the generation and/or guidance of movement based on visual cues.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				J. Purzner, G. O. Paradiso, D. Cunic, J. A. Saint-Cyr, T. Hoque, A. M. Lozano, A. E. Lang, E. Moro, M. Hodaie, F. Mazzella, et al. Involvement of the Basal Ganglia and Cerebellar Motor Pathways in the Preparation of Self-Initiated and Externally Triggered Movements in Humans J. Neurosci., May 30, 2007; 27(22): 6029 - 6036. [Abstract] [Full Text] [PDF]

				A. J. Suminski, S. M. Rao, K. M. Mosier, and R. A. Scheidt Neural and Electromyographic Correlates of Wrist Posture Control J Neurophysiol, February 1, 2007; 97(2): 1527 - 1545. [Abstract] [Full Text] [PDF]

				O. B. Miles, N. L. Cerminara, and D. E. Marple-Horvat Purkinje cells in the lateral cerebellum of the cat encode visual events and target motion during visually guided reaching J. Physiol., March 15, 2006; 571(3): 619 - 637. [Abstract] [Full Text] [PDF]

				D. E. Vaillancourt, M. A. Mayka, and D. M. Corcos Intermittent Visuomotor Processing in the Human Cerebellum, Parietal Cortex, and Premotor Cortex J Neurophysiol, February 1, 2006; 95(2): 922 - 931. [Abstract] [Full Text] [PDF]

				S. Torriero, M. Oliveri, G. Koch, C. Caltagirone, and L. Petrosini Interference of Left and Right Cerebellar rTMS with Procedural Learning J. Cogn. Neurosci., November 1, 2004; 16(9): 1605 - 1611. [Abstract] [Full Text] [PDF]

				M. L. MacMillan, J. O. Dostrovsky, A. M. Lozano, and W. D. Hutchison Involvement of Human Thalamic Neurons in Internally and Externally Generated Movements J Neurophysiol, February 1, 2004; 91(2): 1085 - 1090. [Abstract] [Full Text] [PDF]

				D. E. Vaillancourt, K. R. Thulborn, and D. M. Corcos Neural Basis for the Processes That Underlie Visually Guided and Internally Guided Force Control in Humans J Neurophysiol, November 1, 2003; 90(5): 3330 - 3340. [Abstract] [Full Text] [PDF]

				N. Picard and P. L. Strick Activation of the Supplementary Motor Area (SMA) during Performance of Visually Guided Movements Cereb Cortex, September 1, 2003; 13(9): 977 - 986. [Abstract] [Full Text] [PDF]

				M. Pessiglione, D. Guehl, Y. Agid, E. C. Hirsch, J. Feger, and L. Tremblay Impairment of context-adapted movement selection in a primate model of presymptomatic Parkinson's disease Brain, June 1, 2003; 126(6): 1392 - 1408. [Abstract] [Full Text] [PDF]

				J. J. Barski, J. Hartmann, C. R. Rose, F. Hoebeek, K. Morl, M. Noll-Hussong, C. I. De Zeeuw, A. Konnerth, and M. Meyer Calbindin in Cerebellar Purkinje Cells Is a Critical Determinant of the Precision of Motor Coordination J. Neurosci., April 15, 2003; 23(8): 3469 - 3477. [Abstract] [Full Text] [PDF]

				P. Maquet, S. Schwartz, R. Passingham, and C. Frith Sleep-Related Consolidation of a Visuomotor Skill: Brain Mechanisms as Assessed by Functional Magnetic Resonance Imaging J. Neurosci., February 15, 2003; 23(4): 1432 - 1440. [Abstract] [Full Text] [PDF]

				R. P. Dum and P. L. Strick An Unfolded Map of the Cerebellar Dentate Nucleus and its Projections to the Cerebral Cortex J Neurophysiol, January 1, 2003; 89(1): 634 - 639. [Abstract] [Full Text] [PDF]

				R. P. DUM, C. LI, and P. L. STRICK Motor and Nonmotor Domains in the Monkey Dentate Ann. N.Y. Acad. Sci., December 1, 2002; 978(1): 289 - 301. [Abstract] [Full Text] [PDF]

				J. Doyon, A. W. Song, A. Karni, F. Lalonde, M. M. Adams, and L. G. Ungerleider Experience-dependent changes in cerebellar contributions to motor sequence learning PNAS, January 22, 2002; 99(2): 1017 - 1022. [Abstract] [Full Text] [PDF]

				R. G. Brown, L. Redondo-Verge, J. R. Chacon, M. L. Lucas, and S. Channon Dissociation between intentional and incidental sequence learning in Huntington's disease Brain, November 1, 2001; 124(11): 2188 - 2202. [Abstract] [Full Text] [PDF]

				F. A. Middleton and P. L. Strick Cerebellar Projections to the Prefrontal Cortex of the Primate J. Neurosci., January 15, 2001; 21(2): 700 - 712. [Abstract] [Full Text] [PDF]

				R. J. Perry and S. Zeki The neurology of saccades and covert shifts in spatial attention: An event-related fMRI study Brain, November 1, 2000; 123(11): 2273 - 2288. [Abstract] [Full Text] [PDF]

				P. van Donkelaar, J. F. Stein, R. E. Passingham, and R. C. Miall Temporary Inactivation in the Primate Motor Thalamus During Visually Triggered and Internally Generated Limb Movements J Neurophysiol, May 1, 2000; 83(5): 2780 - 2790. [Abstract] [Full Text] [PDF]

				P. van Donkelaar, J. F. Stein, R. E. Passingham, and R. C. Miall Neuronal Activity in the Primate Motor Thalamus During Visually Triggered and Internally Generated Limb Movements J Neurophysiol, August 1, 1999; 82(2): 934 - 945. [Abstract] [Full Text] [PDF]

				K. Nakamura, K. Sakai, and O. Hikosaka Effects of Local Inactivation of Monkey Medial Frontal Cortex in Learning of Sequential Procedures J Neurophysiol, August 1, 1999; 82(2): 1063 - 1068. [Abstract] [Full Text] [PDF]

				K. Nakamura, K. Sakai, and O. Hikosaka Neuronal Activity in Medial Frontal Cortex During Learning of Sequential Procedures J Neurophysiol, November 1, 1998; 80(5): 2671 - 2687. [Abstract] [Full Text] [PDF]

				R. S. Turner, S. T. Grafton, J. R. Votaw, M. R. Delong, and J. M. Hoffman Motor Subcircuits Mediating the Control of Movement Velocity: A PET Study J Neurophysiol, October 1, 1998; 80(4): 2162 - 2176. [Abstract] [Full Text] [PDF]

				N. Picard and P. L. Strick Activation on the Medial Wall During Remembered Sequences of Reaching Movements in Monkeys J Neurophysiol, April 1, 1997; 77(4): 2197 - 2201. [Abstract] [Full Text] [PDF]

				S. Kim, K Ugurbil, and P. Strick Activation of a cerebellar output nucleus during cognitive processing Science, August 12, 1994; 265(5174): 949 - 951. [Abstract] [PDF]