| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 71, Issue 2 575-582, Copyright © 1994 by APS
ARTICLES |
E. Puil, H. Meiri and Y. Yarom
Department of Neurobiology, Hebrew University, Jerusalem, Israel.
1. We studied the voltage responses of thalamocortical neurons to a periodic current input of variable frequency, in slices of mediodorsal thalamus (guinea pig). The ratio of the Fourier transform of the voltage response to the Fourier transform of the oscillatory current input was used to calculate the frequency response of the neurons at different resting and imposed membrane potentials. 2. Most neurons displayed a resonant hump in the frequency response curve. A narrow band of low-frequency (2-4 Hz) resonance occurred near the resting level [-66 +/- 8 mV (SD)] and at imposed membrane potentials in a range of -60 to -80 mV. An additional wide band (12-26 Hz) of peak resonant frequencies was observed at depolarized levels. 3. The low-frequency resonance was insensitive to tetrodotoxin (TTX) application in concentrations (0.5-1 microM) that blocked a depolarization activated inward rectifier and Na(+)-dependent action potentials. TTX, however, eliminated the wide-band resonant hump centered at 12-26 Hz that we observed at depolarized membrane potentials. 4. Application of Ni2+ (0.5-1 mM) reversibly blocked all slow spikes and greatly reduced the low-frequency resonant humps, without changing the resting potential. Octanol in concentrations of 50 microM had similar effects. 5. Application of Cs+ (3-5 mM), a blocker of the hyperpolarization activated inward rectifier, produced a 5- to 10-mV depolarization and completely blocked the rectification. Cs+ did not alter the low-frequency resonant hump or its dependence on membrane voltage.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  R. C. Muresan, O. F. Jurjut, V. V. Moca, W. Singer, and D. Nikolic The Oscillation Score: An Efficient Method for Estimating Oscillation Strength in Neuronal Activity J Neurophysiol, March 1, 2008; 99(3): 1333 - 1353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Muresan and C. Savin Resonance or Integration? Self-Sustained Dynamics and Excitability of Neural Microcircuits J Neurophysiol, March 1, 2007; 97(3): 1911 - 1930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I Erchova, G Kreck, U Heinemann, and A. V. M Herz Dynamics of rat entorhinal cortex layer II and III cells: characteristics of membrane potential resonance at rest predict oscillation properties near threshold J. Physiol., October 1, 2004; 560(1): 89 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. E. Richardson, N. Brunel, and V. Hakim From Subthreshold to Firing-Rate Resonance J Neurophysiol, May 1, 2003; 89(5): 2538 - 2554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Wu, C.-F. Hsiao, and S. H. Chandler Membrane Resonance and Subthreshold Membrane Oscillations in Mesencephalic V Neurons: Participants in Burst Generation J. Neurosci., June 1, 2001; 21(11): 3729 - 3739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gutierrez, C. L. Cox, J. Rinzel, and S. M. Sherman Dynamics of Low-Threshold Spike Activation in Relay Neurons of the Cat Lateral Geniculate Nucleus J. Neurosci., February 1, 2001; 21(3): 1022 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Amir, M. Michaelis, and M. Devor Membrane Potential Oscillations in Dorsal Root Ganglion Neurons: Role in Normal Electrogenesis and Neuropathic Pain J. Neurosci., October 1, 1999; 19(19): 8589 - 8596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tennigkeit, D. W. F. Schwarz, and E. Puil Effects of Metabotropic Glutamate Receptor Activation in Auditory Thalamus J Neurophysiol, August 1, 1999; 82(2): 718 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Talley, L. L. Cribbs, J.-H. Lee, A. Daud, E. Perez-Reyes, and D. A. Bayliss Differential Distribution of Three Members of a Gene Family Encoding Low Voltage-Activated (T-Type) Calcium Channels J. Neurosci., March 15, 1999; 19(6): 1895 - 1911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Frantseva, J. L. P. Velazquez, and P. L. Carlen Changes in Membrane and Synaptic Properties of Thalamocortical Circuitry Caused by Hydrogen Peroxide J Neurophysiol, September 1, 1998; 80(3): 1317 - 1326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tennigkeit, C. R. Ries, D. W. F. Schwarz, and E. Puil Isoflurane Attenuates Resonant Responses of Auditory Thalamic Neurons J Neurophysiol, August 1, 1997; 78(2): 591 - 596. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
