JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 71: 802-807, 1994;
0022-3077/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Casey, K. L.
Right arrow Articles by Frey, K. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Casey, K. L.
Right arrow Articles by Frey, K. A.

Journal of Neurophysiology, Vol 71, Issue 2 802-807, Copyright © 1994 by APS

ARTICLES

Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli

K. L. Casey, S. Minoshima, K. L. Berger, R. A. Koeppe, T. J. Morrow and K. A. Frey
Department of Neurology, University of Michigan, Ann Arbor 48109.

1. To identify the forebrain and brain stem structures that are active during the perception of acute heat pain in humans, we performed H2 15O positron emission tomographic (PET) analyses of cerebral blood flow (CBF) on nine normal volunteers while they received repetitive noxious (50 degrees C) and innocuous (40 degrees C) 5 s heat pulses to the forearm (average resting temperature of 31.8 degrees C). Each subject rated the subjective intensity of each stimulation series according to a magnitude estimation procedure in which 0 = no heat sensation, 7 = barely painful, and 10 = barely tolerable. 2. Three scans were performed at each temperature. Mean CBF images were created for each experimental condition and oriented onto standardized stereotaxic coordinates. Subtraction images were created between conditions for each subject and averaged across subjects. Volumes of interest (VOI) were chosen, based on a priori hypotheses and the results of previously published PET studies. In addition, a separate statistical summation analysis of individual voxels was performed. Statistical thresholds were established with corrections for multiple comparisons. 3. Significant CBF increases to 50 degrees C stimuli were found in the contralateral thalamus, cingulate cortex, S2 and S1 cortex, and insula. The ipsilateral S2 cortex and thalamus, and the medial dorsal midbrain and cerebellar vermis also showed significant CBF increases. All subjects rated the 50 degrees C stimuli as painful (average subjective rating = 8.9 +/- 0.9 SD) and the 40 degrees C stimuli as warm, but not painful (average subjective rating = 2.1 +/- 1.0).(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
S. Davidson, X. Zhang, S. G. Khasabov, D. A. Simone, and G. J. Giesler Jr.
Termination Zones of Functionally Characterized Spinothalamic Tract Neurons Within the Primate Posterior Thalamus
J Neurophysiol, October 1, 2008; 100(4): 2026 - 2037.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
J. C. Murrell, S. L. Mitchinson, D. Waters, and C. B. Johnson
Comparative effect of thermal, mechanical, and electrical noxious stimuli on the electroencephalogram of the rat
Br. J. Anaesth., March 1, 2007; 98(3): 366 - 371.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
L. Mazzola, J. Isnard, and F. Mauguiere
Somatosensory and Pain Responses to Stimulation of the Second Somatosensory Area (SII) in Humans. A Comparison with SI and Insular Responses
Cereb Cortex, July 1, 2006; 16(7): 960 - 968.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. S. Ruehle, H. O. Handwerker, J. K. M. Lennerz, R. Ringler, and C. Forster
Brain activation during input from mechanoinsensitive versus polymodal C-nociceptors.
J. Neurosci., May 17, 2006; 26(20): 5492 - 5499.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
C. A. Bagley, S. Ohara, H. C. Lawson, and F. A. Lenz
Psychophysics of CNS pain-related activity: binary and analog channels and memory encoding.
Neuroscientist, February 1, 2006; 12(1): 29 - 42.
[Abstract] [PDF]

Home page
 NeurologyHome page
C. L. Kwan, N. E. Diamant, G. Pope, K. Mikula, D. J. Mikulis, and K. D. Davis
Abnormal forebrain activity in functional bowel disorder patients with chronic pain
Neurology, October 25, 2005; 65(8): 1268 - 1277.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C.-C. Kuo and C.-T. Yen
Comparison of Anterior Cingulate and Primary Somatosensory Neuronal Responses to Noxious Laser-Heat Stimuli in Conscious, Behaving Rats
J Neurophysiol, September 1, 2005; 94(3): 1825 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. K. Senapati, S. C. Lagraize, P. J. Huntington, H. D. Wilson, P. N. Fuchs, and Y. B. Peng
Electrical Stimulation of the Anterior Cingulate Cortex Reduces Responses of Rat Dorsal Horn Neurons to Mechanical Stimuli
J Neurophysiol, July 1, 2005; 94(1): 845 - 851.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
M. S. Milak, R. V. Parsey, J. Keilp, M. A. Oquendo, K. M. Malone, and J. J. Mann
Neuroanatomic Correlates of Psychopathologic Components of Major Depressive Disorder
Arch Gen Psychiatry, April 1, 2005; 62(4): 397 - 408.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
C H Wilder-Smith, D Schindler, K Lovblad, S M Redmond, and A Nirkko
Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls
Gut, November 1, 2004; 53(11): 1595 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. A. Strigo, G. H. Duncan, M. Boivin, and M. C. Bushnell
Differentiation of Visceral and Cutaneous Pain in the Human Brain
J Neurophysiol, June 1, 2003; 89(6): 3294 - 3303.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
A. May
Headache: lessons learned from functional imaging
Br. Med. Bull., March 1, 2003; 65(1): 223 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
I. H. Lorenz, C. Kolbitsch, M. Hinteregger, P. Bauer, M. Spiegel, T. J. Luger, C. Schmidauer, W. Streif, K. P. Pfeiffer, and A. Benzer
Remifentanil and nitrous oxide reduce changes in cerebral blood flow velocity in the middle cerebral artery caused by pain
Br. J. Anaesth., March 1, 2003; 90(3): 296 - 299.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Frot and F. Mauguiere
Dual representation of pain in the operculo-insular cortex in humans
Brain, February 1, 2003; 126(2): 438 - 450.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. E. Lake III and J. R. Saper
Chronic headache: New advances in treatment strategies
Neurology, September 10, 2002; 59(90052): S8 - 13.
[Abstract] [Full Text]

Home page
 Cereb CortexHome page
K. Ostrowsky, M. Magnin, P. Ryvlin, J. Isnard, M. Guenot, and F. Mauguiere
Representation of Pain and Somatic Sensation in the Human Insula: a Study of Responses to Direct Electrical Cortical Stimulation
Cereb Cortex, April 1, 2002; 12(4): 376 - 385.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. Fabri, G. Polonara, A. Quattrini, and U. Salvolini
Mechanical Noxious Stimuli Cause Bilateral Activation of Parietal Operculum in Callosotomized Subjects
Cereb Cortex, April 1, 2002; 12(4): 446 - 451.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Buchel, K. Bornhovd, M. Quante, V. Glauche, B. Bromm, and C. Weiller
Dissociable Neural Responses Related to Pain Intensity, Stimulus Intensity, and Stimulus Awareness within the Anterior Cingulate Cortex: A Parametric Single-Trial Laser Functional Magnetic Resonance Imaging Study
J. Neurosci., February 1, 2002; 22(3): 970 - 976.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L. J. Vogt, L. J. Sim-Selley, S. R. Childers, R. G. Wiley, and B. A. Vogt
Colocalization of {micro}-Opioid Receptors and Activated G-Proteins in Rat Cingulate Cortex
J. Pharmacol. Exp. Ther., December 1, 2001; 299(3): 840 - 848.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
N. Witting, R. C. Kupers, P. Svensson, L. Arendt-Nielsen; A. Gjedde, and T. S. Jensen
Experimental brush-evoked allodynia activates posterior parietal cortex
Neurology, November 27, 2001; 57(10): 1817 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
R. K. Fulbright, C. J. Troche, P. Skudlarski, J. C. Gore, and B. E. Wexler
Functional MR Imaging of Regional Brain Activation Associated with the Affective Experience of Pain
Am. J. Roentgenol., November 1, 2001; 177(5): 1205 - 1210.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Timmermann, M. Ploner, K. Haucke, F. Schmitz, R. Baltissen, and A. Schnitzler
Differential Coding of Pain Intensity in the Human Primary and Secondary Somatosensory Cortex
J Neurophysiol, September 1, 2001; 86(3): 1499 - 1503.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Y. Saab, M. Kawasaki, E. D. Al-Chaer, and W. D. Willis
Cerebellar Cortical Stimulation Increases Spinal Visceral Nociceptive Responses
J Neurophysiol, June 1, 2001; 85(6): 2359 - 2363.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Sawamoto, M. Honda, T. Okada, T. Hanakawa, M. Kanda, H. Fukuyama, J. Konishi, and H. Shibasaki
Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study
J. Neurosci., October 1, 2000; 20(19): 7438 - 7445.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
C. Créac'h, P. Henry, J. M. Caillé, and M. Allard
Functional MR Imaging Analysis of Pain-related Brain Activation after Acute Mechanical Stimulation
AJNR Am. J. Neuroradiol., August 1, 2000; 21(8): 1402 - 1406.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
U. Ladabaum, S. Minoshima, and C. Owyang
Pathobiology of Visceral Pain: Molecular Mechanisms and Therapeutic Implications V. Central nervous system processing of somatic and visceral sensory signals
Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G1 - G6.
[Abstract] [Full Text] [PDF]

Home page
 Psychosom. Med.Home page
O. G. Cameron, J. K. Zubieta, L. Grunhaus, and S. Minoshima
Effects of Yohimbine on Cerebral Blood Flow, Symptoms, and Physiological Functions in Humans
Psychosom Med, July 1, 2000; 62(4): 549 - 559.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. V. Apkarian, P. A. Gelnar, B. R. Krauss, and N. M. Szeverenyi
Cortical Responses to Thermal Pain Depend on Stimulus Size: A Functional MRI Study
J Neurophysiol, May 1, 2000; 83(5): 3113 - 3122.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Q. Aziz, D. G. Thompson, V. W. K. Ng, S. Hamdy, S. Sarkar, M. J. Brammer, E. T. Bullmore, A. Hobson, I. Tracey, L. Gregory, et al.
Cortical Processing of Human Somatic and Visceral Sensation
J. Neurosci., April 1, 2000; 20(7): 2657 - 2663.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Blomqvist, E.-T. Zhang, and A. D. Craig
Cytoarchitectonic and immunohistochemical characterization of a specific pain and temperature relay, the posterior portion of the ventral medial nucleus, in the human thalamus
Brain, March 1, 2000; 123(3): 601 - 619.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Monconduit, L. Bourgeais, J.-F. Bernard, D. Le Bars, and L. Villanueva
Ventromedial Thalamic Neurons Convey Nociceptive Signals from the Whole Body Surface to the Dorsolateral Neocortex
J. Neurosci., October 15, 1999; 19(20): 9063 - 9072.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. C. Coghill, C. N. Sang, J. Ma. Maisog, and M. J. Iadarola
Pain Intensity Processing Within the Human Brain: A Bilateral, Distributed Mechanism
J Neurophysiol, October 1, 1999; 82(4): 1934 - 1943.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. Peyron, L. Garcia-Larrea, M.-C. Gregoire, N. Costes, P. Convers, F. Lavenne, F. Mauguiere, D. Michel, and B. Laurent
Haemodynamic brain responses to acute pain in humans: Sensory and attentional networks
Brain, September 1, 1999; 122(9): 1765 - 1780.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. Baron, Y. Baron, E. Disbrow, and T. P. L. Roberts
Brain processing of capsaicin-induced secondary hyperalgesia: A functional MRI study
Neurology, August 1, 1999; 53(3): 548 - 548.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. L. Casey
Forebrain mechanisms of nociception and pain: Analysis through imaging
PNAS, July 6, 1999; 96(14): 7668 - 7674.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Ploghaus, I. Tracey, J. S. Gati, S. Clare, R. S. Menon, P. M. Matthews, and J. N. P. Rawlins
Dissociating Pain from Its Anticipation in the Human Brain
Science, June 18, 1999; 284(5422): 1979 - 1981.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
A. V. Apkarian, A. Darbar, B. R. Krauss, P. A. Gelnar, and N. M. Szeverenyi
Differentiating Cortical Areas Related to Pain Perception From Stimulus Identification: Temporal Analysis of fMRI Activity
J Neurophysiol, June 1, 1999; 81(6): 2956 - 2963.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
B. P Radanov, I. Bicik, J. Dvorak, J. Antinnes, G. K von Schulthess, and A. Buck
Relation between neuropsychological and neuroimaging findings in patients with late whiplash syndrome
J. Neurol. Neurosurg. Psychiatry, April 1, 1999; 66(4): 485 - 489.
[Abstract] [Full Text]

Home page
 J. Cogn. Neurosci.Home page
P. Rainville, R. K. Hofbauer, G. H. Duncan, M. C. Bushnell, and D. D. Price
Cerebral Mechanisms of Hypnotic Induction and Suggestion
J. Cogn. Neurosci., January 1, 1999; 11(1): 110 - 125.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
C. Shi and M. Davis
Pain Pathways Involved in Fear Conditioning Measured with Fear-Potentiated Startle: Lesion Studies
J. Neurosci., January 1, 1999; 19(1): 420 - 430.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Tommerdahl, K. A. Delemos, O. V. Favorov, C. B. Metz, C. J. Vierck Jr., and B. L. Whitsel
Response of Anterior Parietal Cortex to Different Modes of Same-Site Skin Stimulation
J Neurophysiol, December 1, 1998; 80(6): 3272 - 3283.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. A. Porro, V. Cettolo, M. P. Francescato, and P. Baraldi
Temporal and Intensity Coding of Pain in Human Cortex
J Neurophysiol, December 1, 1998; 80(6): 3312 - 3320.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. H. Duncan, R. C. Kupers, S. Marchand, J.-G. Villemure, J. M. Gybels, and M. C. Bushnell
Stimulation of Human Thalamus for Pain Relief: Possible Modulatory Circuits Revealed by Positron Emission Tomography
J Neurophysiol, December 1, 1998; 80(6): 3326 - 3330.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. A. Lenz, M. Rios, D. Chau, G. L. Krauss, T. A. Zirh, and R. P. Lesser
Painful Stimuli Evoke Potentials Recorded From the Parasylvian Cortex in Humans
J Neurophysiol, October 1, 1998; 80(4): 2077 - 2088.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. D. Davis, C. L. Kwan, A. P. Crawley, and D. J. Mikulis
Functional MRI Study of Thalamic and Cortical Activations Evoked by Cutaneous Heat, Cold, and Tactile Stimuli
J Neurophysiol, September 1, 1998; 80(3): 1533 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. A. Lenz, M. Rios, A. Zirh, D. Chau, G. Krauss, and R. P. Lesser
Painful Stimuli Evoke Potentials Recorded Over the Human Anterior Cingulate Gyrus
J Neurophysiol, April 1, 1998; 79(4): 2231 - 2234.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Chikama, N. R. McFarland, D. G. Amaral, and S. N. Haber
Insular Cortical Projections to Functional Regions of the Striatum Correlate with Cortical Cytoarchitectonic Organization in the Primate
J. Neurosci., December 15, 1997; 17(24): 9686 - 9705.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
A K P Jones and S W G Derbyshire
Reduced cortical responses to noxious heat in patients with rheumatoid arthritis
Ann Rheum Dis, October 1, 1997; 56(10): 601 - 607.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
P. Svensson, S. Minoshima, A. Beydoun, T. J. Morrow, and K. L. Casey
Cerebral Processing of Acute Skin and Muscle Pain in Humans
J Neurophysiol, July 1, 1997; 78(1): 450 - 460.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. D. Davis, S. J. Taylor, A. P. Crawley, M. L. Wood, and D. J. Mikulis
Functional MRI of Pain- and Attention-Related Activations in the Human Cingulate Cortex
J Neurophysiol, June 1, 1997; 77(6): 3370 - 3380.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online