JN Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 71: 831-839, 1994;
0022-3077/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jensen, M. S.
Right arrow Articles by Yaari, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jensen, M. S.
Right arrow Articles by Yaari, Y.

Journal of Neurophysiology, Vol 71, Issue 3 831-839, Copyright © 1994 by APS

ARTICLES

Variant firing patterns in rat hippocampal pyramidal cells modulated by extracellular potassium

M. S. Jensen, R. Azouz and Y. Yaari
Department of Physiology, Hebrew University-Hadassah, School of Medicine, Jerusalem, Israel.

1. The distribution of distinctive firing modes within the population of CA1 pyramidal cells and their modulation by the extracellular concentration of potassium ([K+]o) were investigated with intracellular recordings in rat hippocampal slices. 2. Pyramidal cells were injected with long (> 250 ms) and brief (3-5 ms) positive current pulses of increasing intensity. In normal [K+]o (3.5 mM), most cells (38 of 46 cells; 83%) were regular spiking neurons (generating accommodating trains of independent action potentials during long depolarizations and a single spike in response to brief stimuli). The remaining pyramidal cells (8 of 46; 17%) displayed differential tendencies to generate stereotyped clusters of action potentials, or bursts, according to which they were grouped into three subsets of endogenous bursters: grade I, bursting only when stimulated with long depolarizing current pulses (6 of 46; 13%); grade II, bursting also in response to brief stimulation (1 of 46; 2%); grade III, bursting also spontaneously even in absence of synaptic transmission (1 of 46; 2%). 3. Raising [K+]o from 3.5 to 7.5 mM (high [K+]o) significantly reduced resting membrane potential and input impedance but did not change the threshold potential for eliciting an action potential. 4. Raising [K+]o to 7.5 mM reversibly converted many regular spiking cells to bursters. Likewise, the burst tendency of normally bursting pyramidal cells increased to a higher grade in high [K+]o. Consequently, the fraction of bursters in high [K+]o (17 of 41 cells; 42%) was approximately 2.5-fold higher than in normal [K+]o and their differential distribution was shifted toward higher grades of bursting.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Physiol.Home page
S. Chen and Y. Yaari
Spike Ca2+ influx upmodulates the spike afterdepolarization and bursting via intracellular inhibition of KV7/M channels
J. Physiol., March 1, 2008; 586(5): 1351 - 1363.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y. Yaari, C. Yue, and H. Su
Recruitment of apical dendritic T-type Ca2+ channels by backpropagating spikes underlies de novo intrinsic bursting in hippocampal epileptogenesis
J. Physiol., April 15, 2007; 580(2): 435 - 450.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Golomb, C. Yue, and Y. Yaari
Contribution of Persistent Na+ Current and M-Type K+ Current to Somatic Bursting in CA1 Pyramidal Cells: Combined Experimental and Modeling Study
J Neurophysiol, October 1, 2006; 96(4): 1912 - 1926.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Yue and Y. Yaari
Axo-Somatic and Apical Dendritic Kv7/M Channels Differentially Regulate the Intrinsic Excitability of Adult Rat CA1 Pyramidal Cells
J Neurophysiol, June 1, 2006; 95(6): 3480 - 3495.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Yue, S. Remy, H. Su, H. Beck, and Y. Yaari
Proximal Persistent Na+ Channels Drive Spike Afterdepolarizations and Associated Bursting in Adult CA1 Pyramidal Cells
J. Neurosci., October 19, 2005; 25(42): 9704 - 9720.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Chen, C. Yue, and Y. Yaari
A transitional period of Ca2+-dependent spike afterdepolarization and bursting in developing rat CA1 pyramidal cells
J. Physiol., August 15, 2005; 567(1): 79 - 93.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. E. Metz, T. Jarsky, M. Martina, and N. Spruston
R-Type Calcium Channels Contribute to Afterdepolarization and Bursting in Hippocampal CA1 Pyramidal Neurons
J. Neurosci., June 15, 2005; 25(24): 5763 - 5773.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Spanswick and L. P. Renaud
Angiotensin II Induces Calcium-Dependent Rhythmic Activity in a Subpopulation of Rat Hypothalamic Median Preoptic Nucleus Neurons
J Neurophysiol, April 1, 2005; 93(4): 1970 - 1976.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Yue and Y. Yaari
KCNQ/M Channels Control Spike Afterdepolarization and Burst Generation in Hippocampal Neurons
J. Neurosci., May 12, 2004; 24(19): 4614 - 4624.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. K. Tryba, F. Pena, and J.-M. Ramirez
Stabilization of Bursting in Respiratory Pacemaker Neurons
J. Neurosci., April 15, 2003; 23(8): 3538 - 3546.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J O Willoughby, S P Fitzgibbon, K J Pope, L Mackenzie, A V Medvedev, C R Clark, M P Davey, and R A Wilcox
Persistent abnormality detected in the non-ictal electroencephalogram in primary generalised epilepsy
J. Neurol. Neurosurg. Psychiatry, January 1, 2003; 74(1): 51 - 55.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Timofeev, M. Bazhenov, T. Sejnowski, and M. Steriade
Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities
PNAS, July 9, 2002; 99(14): 9533 - 9537.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Su, D. Sochivko, A. Becker, J. Chen, Y. Jiang, Y. Yaari, and H. Beck
Upregulation of a T-Type Ca2+ Channel Causes a Long-Lasting Modification of Neuronal Firing Mode after Status Epilepticus
J. Neurosci., May 1, 2002; 22(9): 3645 - 3655.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. D'Ambrosio, D. S. Gordon, and H. R. Winn
Differential Role of KIR Channel and Na+/K+-Pump in the Regulation of Extracellular K+ in Rat Hippocampus
J Neurophysiol, January 1, 2002; 87(1): 87 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Doiron, A. Longtin, R. W. Turner, and L. Maler
Model of Gamma Frequency Burst Discharge Generated by Conditional Backpropagation
J Neurophysiol, October 1, 2001; 86(4): 1523 - 1545.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. K. Tallent, S. G. Madamba, and G. R. Siggins
Nociceptin Reduces Epileptiform Events in CA3 Hippocampus via Presynaptic and Postsynaptic Mechanisms
J. Neurosci., September 1, 2001; 21(17): 6940 - 6948.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Su, G. Alroy, E. D. Kirson, and Y. Yaari
Extracellular Calcium Modulates Persistent Sodium Current-Dependent Burst-Firing in Hippocampal Pyramidal Neurons
J. Neurosci., June 15, 2001; 21(12): 4173 - 4182.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. L. Hardison, M. M. Okazaki, and J. V. Nadler
Modest Increase in Extracellular Potassium Unmasks Effect of Recurrent Mossy Fiber Growth
J Neurophysiol, November 1, 2000; 84(5): 2380 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. P. Staff, H.-Y. Jung, T. Thiagarajan, M. Yao, and N. Spruston
Resting and Active Properties of Pyramidal Neurons in Subiculum and CA1 of Rat Hippocampus
J Neurophysiol, November 1, 2000; 84(5): 2398 - 2408.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. C. Brumberg, L. G. Nowak, and D. A. McCormick
Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons
J. Neurosci., July 1, 2000; 20(13): 4829 - 4843.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. C. Magee and M. Carruth
Dendritic Voltage-Gated Ion Channels Regulate the Action Potential Firing Mode of Hippocampal CA1 Pyramidal Neurons
J Neurophysiol, October 1, 1999; 82(4): 1895 - 1901.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. D'Ambrosio, D. O. Maris, M. S. Grady, H. R. Winn, and D. Janigro
Impaired K+ Homeostasis and Altered Electrophysiological Properties of Post-Traumatic Hippocampal Glia
J. Neurosci., September 15, 1999; 19(18): 8152 - 8162.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. J. Thomas, A. M. Watabe, T. D. Moody, M. Makhinson, and T. J. O'Dell
Postsynaptic Complex Spike Bursting Enables the Induction of LTP by Theta Frequency Synaptic Stimulation
J. Neurosci., September 15, 1998; 18(18): 7118 - 7126.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. A. Rutecki and Y. Yang
Ictal Epileptiform Activity in the CA3 Region of Hippocampal Slices Produced by Pilocarpine
J Neurophysiol, June 1, 1998; 79(6): 3019 - 3029.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Pan and J. L. Stringer
Role of Potassium and Calcium in the Generation of Cellular Bursts in the Dentate Gyrus
J Neurophysiol, May 1, 1997; 77(5): 2293 - 2299.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. S. Jensen and Y. Yaari
Role of Intrinsic Burst Firing, Potassium Accumulation, and Electrical Coupling in the Elevated Potassium Model of Hippocampal Epilepsy
J Neurophysiol, March 1, 1997; 77(3): 1224 - 1233.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online