| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 71, Issue 6 2446-2462, Copyright © 1994 by APS
ARTICLES |
I. Nelken and E. D. Young
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
1. The principal cells of the dorsal cochlear nucleus (DCN) are mostly inhibited by best frequency (BF) tones but are mostly excited by broadband noise (BBN), producing the so-called type IV response characteristic. The narrowband inhibitory responses can be explained by the inhibitory influence of interneurons with type II response characteristics. However, it is not clear that all the details of the type IV responses can be accounted for by this neural circuit. In particular, many type IV units are inhibited by band-reject noise (notch noise); type II units tend to be only weakly excited by these stimuli, if at all. In this paper we study the relationships between the narrowband, inhibitory and the wideband, excitatory regimens of the type IV responses and present the case for the existence of a second inhibitory source in DCN, called the wideband inhibitor (WBI) below. 2. Type IV units were studied using pure tones, noise bands arithmetically centered on BF, notch noise centered on BF, and BBN. We measured the rate-level function (response rate as function of stimulus level) for each stimulus. This paper is based on the responses of 28 type IV units. 3. Evidence for low-threshold inhibitory input to type IV units is derived from analysis of rate-level functions at sound levels just above threshold. Notch noise stimuli of the appropriate notch width produce inhibition at threshold in this regime. When BBN is presented, this inhibition appears to summate with excitation produced by energy in the band of noise centered on BF, resulting in BBN rate-level functions with decreased slope and maximum firing rate. A range of slopes and maximal firing rates is observed, but these variables are strongly correlated and they are negatively correlated with the strength of the inhibition produced by notch noise; this result supports the conclusion that a single inhibitory source is responsible for these effects. 4. By contrast, there is a weak (nonsignificant) positive correlation between the strength of the inhibitory effect of notch noise and the slope/maximal firing rate in response to narrowband stimuli, including BF tones. The contrast between this positive nonsignificant correlation and the significant negative correlation mentioned above suggests that more than one inhibitory effect operates: specifically, the type II input is responsible for inhibition by narrowband stimuli and a different inhibitory source, the WBI, produces inhibition by notch stimuli. 5. Several lines of evidence are given to show that type II units cannot produce the inhibition seen with notch noise stimuli.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
|
|
 |
|
  W. H.A.M. Mulders, A. R. Harvey, and D. Robertson Electrically Evoked Responses in Onset Chopper Neurons in Guinea Pig Cochlear Nucleus J Neurophysiol, May 1, 2007; 97(5): 3288 - 3297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kim and L. O. Trussell Ion Channels Generating Complex Spikes in Cartwheel Cells of the Dorsal Cochlear Nucleus J Neurophysiol, February 1, 2007; 97(2): 1705 - 1725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. A. Rodrigues and D. Oertel Hyperpolarization-Activated Currents Regulate Excitability in Stellate Cells of the Mammalian Ventral Cochlear Nucleus J Neurophysiol, January 1, 2006; 95(1): 76 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Caspary, T. A. Schatteman, and L. F. Hughes Age-Related Changes in the Inhibitory Response Properties of Dorsal Cochlear Nucleus Output Neurons: Role of Inhibitory Inputs J. Neurosci., November 23, 2005; 25(47): 10952 - 10959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. J. Reiss and E. D. Young Spectral Edge Sensitivity in Neural Circuits of the Dorsal Cochlear Nucleus J. Neurosci., April 6, 2005; 25(14): 3680 - 3691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Neuert, J. L. Verhey, and I. M. Winter Responses of Dorsal Cochlear Nucleus Neurons to Signals in the Presence of Modulated Maskers J. Neurosci., June 23, 2004; 24(25): 5789 - 5797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. X. JORIS, C. E. SCHREINER, and A. REES Neural Processing of Amplitude-Modulated Sounds Physiol Rev, April 1, 2004; 84(2): 541 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Poirier, F. K. Samson, and T. J. Imig Spectral Shape Sensitivity Contributes to the Azimuth Tuning of Neurons in the Cat's Inferior Colliculus J Neurophysiol, May 1, 2003; 89(5): 2760 - 2777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kopp-Scheinpflug, S. Dehmel, G. J. Dorrscheidt, and R. Rubsamen Interaction of Excitation and Inhibition in Anteroventral Cochlear Nucleus Neurons That Receive Large Endbulb Synaptic Endings J. Neurosci., December 15, 2002; 22(24): 11004 - 11018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Ghazanfar, J. G. Neuhoff, and N. K. Logothetis Auditory looming perception in rhesus monkeys PNAS, November 26, 2002; 99(24): 15755 - 15757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Hancock and H. F. Voigt Intracellularly Labeled Fusiform Cells in Dorsal Cochlear Nucleus of the Gerbil. I. Physiological Response Properties J Neurophysiol, May 1, 2002; 87(5): 2505 - 2519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Hancock and H. F. Voigt Intracellularly Labeled Fusiform Cells in Dorsal Cochlear Nucleus of the Gerbil. II. Comparison of Physiology and Anatomy J Neurophysiol, May 1, 2002; 87(5): 2520 - 2530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Davis Evidence of a Functionally Segregated Pathway From Dorsal Cochlear Nucleus to Inferior Colliculus J Neurophysiol, April 1, 2002; 87(4): 1824 - 1835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fujino and D. Oertel Cholinergic Modulation of Stellate Cells in the Mammalian Ventral Cochlear Nucleus J. Neurosci., September 15, 2001; 21(18): 7372 - 7383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Gardner, L. O. Trussell, and D. Oertel Correlation of AMPA Receptor Subunit Composition with Synaptic Input in the Mammalian Cochlear Nuclei J. Neurosci., September 15, 2001; 21(18): 7428 - 7437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pressnitzer, R. Meddis, R. Delahaye, and I. M. Winter Physiological Correlates of Comodulation Masking Release in the Mammalian Ventral Cochlear Nucleus J. Neurosci., August 15, 2001; 21(16): 6377 - 6386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. O. Kanold and P. B. Manis A Physiologically Based Model of Discharge Pattern Regulation by Transient K+ Currents in Cochlear Nucleus Pyramidal Cells J Neurophysiol, February 1, 2001; 85(2): 523 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Yu and E. D. Young Linear and nonlinear pathways of spectral information transmission in the cochlear nucleus PNAS, October 24, 2000; 97(22): 11780 - 11786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. K. Samson, P. Barone, W. A. Irons, J. C. Clarey, P. Poirier, and T. J. Imig Directionality Derived From Differential Sensitivity to Monaural and Binaural Cues in the Cat's Medial Geniculate Body J Neurophysiol, September 1, 2000; 84(3): 1330 - 1345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Imig, N. G. Bibikov, P. Poirier, and F. K. Samson Directionality Derived From Pinna-Cue Spectral Notches in Cat Dorsal Cochlear Nucleus J Neurophysiol, February 1, 2000; 83(2): 907 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Davis and E. D. Young Pharmacological Evidence of Inhibitory and Disinhibitory Neuronal Circuits in Dorsal Cochlear Nucleus J Neurophysiol, February 1, 2000; 83(2): 926 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ding, T. E. Benson, and H. F. Voigt Acoustic and Current-Pulse Responses of Identified Neurons in the Dorsal Cochlear Nucleus of Unanesthetized, Decerebrate Gerbils J Neurophysiol, December 1, 1999; 82(6): 3434 - 3457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Spirou, K. A. Davis, I. Nelken, and E. D. Young Spectral Integration by Type II Interneurons in Dorsal Cochlear Nucleus J Neurophysiol, August 1, 1999; 82(2): 648 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Rhode Vertical Cell Responses to Sound in Cat Dorsal Cochlear Nucleus J Neurophysiol, August 1, 1999; 82(2): 1019 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ramachandran, K. A. Davis, and B. J. May Single-Unit Responses in the Inferior Colliculus of Decerebrate Cats I. Classification Based on Frequency Response Maps J Neurophysiol, July 1, 1999; 82(1): 152 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. X. Joris and P. H. Smith Temporal and Binaural Properties in Dorsal Cochlear Nucleus and Its Output Tract J. Neurosci., December 1, 1998; 18(23): 10157 - 10170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. X. Joris Response Classes in the Dorsal Cochlear Nucleus and Its Output Tract in the Chloralose-Anesthetized Cat J. Neurosci., May 15, 1998; 18(10): 3955 - 3966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Davis and E. D. Young Granule Cell Activation of Complex-Spiking Neurons in Dorsal Cochlear Nucleus J. Neurosci., September 1, 1997; 17(17): 6798 - 6806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Nelken and E. D. Young Linear and Nonlinear Spectral Integration in Type IV Neurons of the Dorsal Cochlear Nucleus. I. Regions of Linear Interaction J Neurophysiol, August 1, 1997; 78(2): 790 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Nelken, P. J. Kim, and E. D. Young Linear and Nonlinear Spectral Integration in Type IV Neurons of the Dorsal Cochlear Nucleus. II. Predicting Responses With the Use of Nonlinear Models J Neurophysiol, August 1, 1997; 78(2): 800 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Davis and H. F. Voigt Evidence of Stimulus-Dependent Correlated Activity in the Dorsal Cochlear Nucleus of Decerebrate Gerbils J Neurophysiol, July 1, 1997; 78(1): 229 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Golding and D. Oertel Physiological Identification of the Targets of Cartwheel Cells in the Dorsal Cochlear Nucleus J Neurophysiol, July 1, 1997; 78(1): 248 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ding and H. F. Voigt Intracellular Response Properties of Units in the Dorsal Cochlear Nucleus of Unanesthetized Decerebrate Gerbil J Neurophysiol, May 1, 1997; 77(5): 2549 - 2572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ghoshal and D. O. Kim Marginal Shell of the Anteroventral Cochlear Nucleus: Single-Unit Response Properties in the Unanesthetized Decerebrate Cat J Neurophysiol, April 1, 1997; 77(4): 2083 - 2097. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
