| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 72, Issue 4 1993-2003, Copyright © 1994 by APS
ARTICLES |
R. A. Warren, A. Agmon and E. G. Jones
Department of Anatomy and Neurobiology, University of California, Irvine 92717.
1. The thalamic reticular nucleus (RTN) has reciprocal connections with relay neurons in the dorsal thalamus. We used whole cell recording in a mouse in vitro slice preparation maintained at room temperature to study the synaptic interactions between the RTN and the ventroposterior thalamic nucleus (VP) during evoked low-frequency oscillations. 2. After a single electrical stimulus of the internal capsule, postsynaptic potentials (PSPs) were recorded in all VP and RTN neurons. In 76% of slices, there was an initial response followed by recurrent PSPs lasting for up to 8 s and with a frequency of approximately 2 Hz in both the VP and RTN. 3. In RTN neurons the initial response consisted of a fast excitatory postsynaptic potential (EPSP) that generated a burst of action potentials. Recurrent PSPs consisted of barrages of EPSPs that often reached burst threshold. The structure of subthreshold EPSP barrages in RTN neurons suggested that they were generated by bursting VP neurons. 4. In VP neurons the stimulus usually evoked a small EPSP followed by a large inhibitory postsynaptic potential (IPSP) that was often followed by a rebound burst. This initial response was often followed by a series of recurrent IPSPs presumably generated by RTN bursts, because intrinsic inhibitory neurons are absent in rodent VP. 5. IPSPs in VP neurons and recurrent EPSPs in RTN neurons were completely abolished by application of a gamma-aminobutyric acid-A (GABAA) receptor antagonist. A GABAB receptor antagonist produced no or little change in either the initial or recurrent response. 6. Recurrent IPSPs in VP neurons were abolished by glutamate receptor antagonists before the initial IPSP, which always remained stimulus dependent. 7. The dependency of recurring IPSPs in VP and recurring EPSPs in RTN upon GABA-mediated inhibition and excitatory amino acid-mediated excitation, plus the character of recurring EPSPs in the RTN strongly suggest that the recurring events were generated through reverse-reciprocal synaptic interactions between VP and RTN neurons. These synaptic interactions most likely play an important role in thalamic oscillations in behavior.
This article has been cited by other articles:
|
|
 |
|
  F. Espinosa, M. A. Torres-Vega, G. A. Marks, and R. H. Joho Ablation of Kv3.1 and Kv3.3 Potassium Channels Disrupts Thalamocortical Oscillations In Vitro and In Vivo J. Neurosci., May 21, 2008; 28(21): 5570 - 5581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Landisman and B. W. Connors VPM and PoM Nuclei of the Rat Somatosensory Thalamus: Intrinsic Neuronal Properties and Corticothalamic Feedback Cereb Cortex, December 1, 2007; 17(12): 2853 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Ying, F. Jia, S. Y. Abbas, F. Hofmann, A. Ludwig, and P. A. Goldstein Dendritic HCN2 Channels Constrain Glutamate-Driven Excitability in Reticular Thalamic Neurons J. Neurosci., August 8, 2007; 27(32): 8719 - 8732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Lee, G. Govindaiah, and C. L. Cox Heterogeneity of firing properties among rat thalamic reticular nucleus neurons J. Physiol., July 1, 2007; 582(1): 195 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pangratz-Fuehrer, U. Rudolph, and J. R. Huguenard Giant Spontaneous Depolarizing Potentials in the Developing Thalamic Reticular Nucleus J Neurophysiol, March 1, 2007; 97(3): 2364 - 2372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Lee and C. L. Cox Excitatory Actions of Vasoactive Intestinal Peptide on Mouse Thalamocortical Neurons Are Mediated by VPAC2 Receptors J Neurophysiol, August 1, 2006; 96(2): 858 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pinault, A. Slezia, and L. Acsady Corticothalamic 5-9 Hz oscillations are more pro-epileptogenic than sleep spindles in rats J. Physiol., July 1, 2006; 574(1): 209 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. Hanganu, Y. Ben-Ari, and R. Khazipov Retinal waves trigger spindle bursts in the neonatal rat visual cortex. J. Neurosci., June 21, 2006; 26(25): 6728 - 6736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang and E. G. Jones Corticothalamic Inhibition in the Thalamic Reticular Nucleus J Neurophysiol, February 1, 2004; 91(2): 759 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-Q. Sun, S. C. Baraban, D. A. Prince, and J. R. Huguenard Target-Specific Neuropeptide Y-Ergic Synaptic Inhibition and Its Network Consequences within the Mammalian Thalamus J. Neurosci., October 22, 2003; 23(29): 9639 - 9649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. DESTEXHE and T. J. SEJNOWSKI Interactions Between Membrane Conductances Underlying Thalamocortical Slow-Wave Oscillations Physiol Rev, October 1, 2003; 83(4): 1401 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Mo and K. T. Blackwell Comparison of Hermissenda Type A and Type B Photoreceptors: Response to Light as a Function of Intensity and Duration J. Neurosci., September 3, 2003; 23(22): 8020 - 8028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Lee and C. L. Cox Vasoactive Intestinal Peptide Selectively Depolarizes Thalamic Relay Neurons and Attenuates Intrathalamic Rhythmic Activity J Neurophysiol, August 1, 2003; 90(2): 1224 - 1234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. S. Sohal, R. Keist, U. Rudolph, and J. R. Huguenard Dynamic GABAA Receptor Subtype-Specific Modulation of the Synchrony and Duration of Thalamic Oscillations J. Neurosci., May 1, 2003; 23(9): 3649 - 3657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Landisman, M. A. Long, M. Beierlein, M. R. Deans, D. L. Paul, and B. W. Connors Electrical Synapses in the Thalamic Reticular Nucleus J. Neurosci., February 1, 2002; 22(3): 1002 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Bourque and A. Kolta Properties and Interconnections of Trigeminal Interneurons of the Lateral Pontine Reticular Formation in the Rat J Neurophysiol, November 1, 2001; 86(5): 2583 - 2596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kuebler, H. Zhang, X. Ren, and M. A. Tanouye Genetic Suppression of Seizure Susceptibility in Drosophila J Neurophysiol, September 1, 2001; 86(3): 1211 - 1225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Jacobsen, D. Ulrich, and J. R. Huguenard GABAB and NMDA Receptors Contribute to Spindle-Like Oscillations in Rat Thalamus In Vitro J Neurophysiol, September 1, 2001; 86(3): 1365 - 1375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kuebler and M. A. Tanouye Modifications of Seizure Susceptibility in Drosophila J Neurophysiol, February 1, 2000; 83(2): 998 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Zhu and F.-S. Lo Three GABA Receptor-Mediated Postsynaptic Potentials in Interneurons in the Rat Lateral Geniculate Nucleus J. Neurosci., July 15, 1999; 19(14): 5721 - 5730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Bartlett and P. H. Smith Anatomic, Intrinsic, and Synaptic Properties of Dorsal and Ventral Division Neurons in Rat Medial Geniculate Body J Neurophysiol, May 1, 1999; 81(5): 1999 - 2016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Zhu, W. W. Lytton, J.-T. Xue, and D. J. Uhlrich An Intrinsic Oscillation in Interneurons of the Rat Lateral Geniculate Nucleus J Neurophysiol, February 1, 1999; 81(2): 702 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Huntsman, D. M. Porcello, G. E. Homanics, T. M. DeLorey, and J. R. Huguenard Reciprocal Inhibitory Connections and Network Synchrony in the Mammalian Thalamus Science, January 22, 1999; 283(5401): 541 - 543. [Abstract] [Full Text]
|
|
|
|
|
|
P. Golshani, R. A. Warren, and E. G. Jones Progression of Change in NMDA, non-NMDA, and Metabotropic Glutamate Receptor Function at the Developing Corticothalamic Synapse J Neurophysiol, July 1, 1998; 80(1): 143 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Timofeev and M. Steriade Cellular Mechanisms Underlying Intrathalamic Augmenting Responses of Reticular and Relay Neurons J Neurophysiol, May 1, 1998; 79(5): 2716 - 2729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Sanchez-Vives and D. A. McCormick Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro J. Neurosci., November 15, 1997; 17(22): 8880 - 8893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Sanchez-Vives, T. Bal, and D. A. McCormick Inhibitory Interactions between Perigeniculate GABAergic Neurons J. Neurosci., November 15, 1997; 17(22): 8894 - 8908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Kim, M. V. Sanchez-Vives, and D. A. McCormick Functional Dynamics of GABAergic Inhibition in the Thalamus Science, October 3, 1997; 278(5335): 130 - 134. [Abstract] [Full Text]
|
|
|
|
|
|
D. Ulrich and J. R. Huguenard GABAA-Receptor-Mediated Rebound Burst Firing and Burst Shunting in Thalamus J Neurophysiol, September 1, 1997; 78(3): 1748 - 1751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Cox, J. R. Huguenard, and D. A. Prince Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus PNAS, August 5, 1997; 94(16): 8854 - 8859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Warren, P. Golshani, and E. G. Jones GABAB-Receptor-Mediated Inhibition in Developing Mouse Ventral Posterior Thalamic Nucleus J Neurophysiol, July 1, 1997; 78(1): 550 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Cox, J. R. Huguenard, and D. A. Prince Peptidergic Modulation of Intrathalamic Circuit Activity In Vitro: Actions of Cholecystokinin J. Neurosci., January 1, 1997; 17(1): 70 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Warren and E. G. Jones Maturation of Neuronal Form and Function in a Mouse Thalamo-Cortical Circuit J. Neurosci., January 1, 1997; 17(1): 277 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Agmon, G. Hollrigel, and D. K. O'Dowd Functional GABAergic Synaptic Connection in Neonatal Mouse Barrel Cortex J. Neurosci., August 1, 1996; 16(15): 4684 - 4695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Huntsman, M. G. Leggio, and E. G. Jones Nucleus-Specific Expression of GABAA Receptor Subunit mRNAs in Monkey Thalamus J. Neurosci., June 1, 1996; 16(11): 3571 - 3589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Golshani, X.-B. Liu, and E. G. Jones Differences in quantal amplitude reflect GluR4- subunit number at corticothalamic synapses on two populations of thalamic neurons PNAS, March 27, 2001; 98(7): 4172 - 4177. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
