JN Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 73: 1308-1312, 1995;
0022-3077/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barthe, J. Y.
Right arrow Articles by Grillner, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barthe, J. Y.
Right arrow Articles by Grillner, S.

Journal of Neurophysiology, Vol 73, Issue 3 1308-1312, Copyright © 1995 by APS

ARTICLES

Neurotensin-induced modulation of spinal neurons and fictive locomotion in the lamprey

J. Y. Barthe and S. Grillner
Nobel Institute for Neurophysiology, Karolinska Institute, Stockholm, Sweden.

1. Neurotensin containing interneurons are present in the spinal cord of both mammalian and nonmammalian vertebrates, but as yet little is known about their functional role. In this study we examine the effect of neurotensin on spinal cells and on the central pattern generator for locomotion in the lamprey spinal cord. 2. Bath application of neurotensin (10(-8) to 10(-6) M) slowed down the fictive locomotor activity induced by the glutamate agonist N-methyl-D-aspartate in the isolated spinal cord. The duration of the bursts of activity in the ventral roots increased in proportion to the increase of the locomotor cycle duration. 3. Intracellular recordings from grey matter neurons and intraspinal stretch receptors neurons showed that neurotensin induced a depolarization [4.4 +/- 0.5 (SE) mV, n = 19]. This depolarization could still be obtained after a blockade of voltage-sensitive sodium channels with tetrodotoxin (1.5 +/- 0.5 mV; n = 6), and after removal of calcium (2.8 +/- 0.4 mV; n = 5). Moreover no consistent change occurred in the fast and slow phase of the afterhyperpolarization (AHP) both of which are carried by potassium currents.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
K. A. Quinlan, P. G. Placas, and J. T. Buchanan
Cholinergic Modulation of the Locomotor Network in the Lamprey Spinal Cord
J Neurophysiol, September 1, 2004; 92(3): 1536 - 1548.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
S. Alford, E. Schwartz, and G. V. Di Prisco
The Pharmacology of Vertebrate Spinal Central Pattern Generators
Neuroscientist, June 1, 2003; 9(3): 217 - 228.
[Abstract] [PDF]

Home page
 J. Exp. Biol.Home page
G. F. Rast
Nitric oxide induces centrally generated motor patterns in the locust suboesophageal ganglion
J. Exp. Biol., January 11, 2001; 204(21): 3789 - 3801.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. Parker
Presynaptic and Interactive Peptidergic Modulation of Reticulospinal Synaptic Inputs in the Lamprey
J Neurophysiol, May 1, 2000; 83(5): 2497 - 2507.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online