| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 73, Issue 4 1584-1599, Copyright © 1995 by APS
ARTICLES |
H. A. Swadlow
Department of Psychology, University of Connecticut, Storrs 06269, USA.
1. Responses of thalamocortical projection neurons and suspected cortical interneurons (SINs) to very brief peripheral stimuli were examined within the vibrissae, the sinus hair, the lip, and the chin representations of ventroposterior medial thalamus (VPM) and primary somatosensory cortex (S1). VPM thalamocortical neurons (N = 40) were identified by their antidromic activation after electrical stimulation of S1. SINs were identified by a high-frequency (> 600 Hz) burst of three or more spikes elicited by suprathreshold stimulation of one or more afferent pathways. SINs also had spikes of very short duration. 2. Previous work has shown that electrical stimulation of VPM elicits a very early and powerful synaptic response in many S1 SINs. Three experimental strategies were employed to test the hypothesis that such responses reflect a monosynaptic VPM input onto SINs and to examine the effects of such input. 1) After a brief peripheral stimulus, the arrival times of VPM thalamocortical impulses in S1 were determined and compared with the initial response times of S1 SINs. 2) Shift-corrected cross-correlograms (CCGs) were constructed from the spike trains of pairs of VPM neurons and SINs that were in precise topographic alignment. 3) Inferences of connectivity based on such CCGs were supported by applying very low-intensity (1-10 microA) microstimulation pulses to the recording microelectrode in VPM and observing evoked responses in the cortical SIN. 3. VPM thalamocortical neurons responded to a brief air puff stimulus at a median latency of 5.05 ms, and the estimated arrival time of the VPM impulses at S1 had a median value of 5.97 ms. This estimate was obtained by adding the antidromic latency of each VPM neuron to the latency of the peripheral stimulus and was supported by similar values obtained from three VPM thalamocortical axons recorded near their termination site within S1. SINs of S1 were among the first cortical neurons to respond to the peripheral stimulus, responding to the air puff at a median latency of 6.6 ms (range 5.7-13.0 ms). The latency of SINs to the peripheral stimulus was strongly related to the latency to gross electrical stimulation of VPM (median value 1.52 ms, r2 = +0.44, P < 0.0001). Many SINs (23 of 34) showed significant shift-corrected CCGs with VPM neurons that were in precise topographic alignment. Most significant CCGs revealed a very brief increase in SIN spike probability (half-amplitude response of approximately 1 ms) that reached a peak value at intervals of 1.4-2.0 ms after the VPM spike.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
|
|
 |
|
  C. R. Stoelzel, Y. Bereshpolova, A. G. Gusev, and H. A. Swadlow The Impact of an LGNd Impulse on the Awake Visual Cortex: Synaptic Dynamics and the Sustained/Transient Distinction J. Neurosci., May 7, 2008; 28(19): 5018 - 5028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Atencio and C. E. Schreiner Spectrotemporal Processing Differences between Auditory Cortical Fast-Spiking and Regular-Spiking Neurons J. Neurosci., April 9, 2008; 28(15): 3897 - 3910. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Tan, H. Hu, Z. J. Huang, and A. Agmon Robust but delayed thalamocortical activation of dendritic-targeting inhibitory interneurons PNAS, February 12, 2008; 105(6): 2187 - 2192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Cardin, L. A. Palmer, and D. Contreras Stimulus Feature Selectivity in Excitatory and Inhibitory Neurons in Primary Visual Cortex J. Neurosci., September 26, 2007; 27(39): 10333 - 10344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Witham and S. N. Baker Network oscillations and intrinsic spiking rhythmicity do not covary in monkey sensorimotor areas J. Physiol., May 1, 2007; 580(3): 801 - 814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rigas and M. A. Castro-Alamancos Thalamocortical Up States: Differential Effects of Intrinsic and Extrinsic Cortical Inputs on Persistent Activity J. Neurosci., April 18, 2007; 27(16): 4261 - 4272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Inoue and K. Imoto Feedforward Inhibitory Connections From Multiple Thalamic Cells to Multiple Regular-Spiking Cells in Layer 4 of the Somatosensory Cortex J Neurophysiol, October 1, 2006; 96(4): 1746 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Stuttgen, J. Ruter, and C. Schwarz Two psychophysical channels of whisker deflection in rats align with two neuronal classes of primary afferents. J. Neurosci., July 26, 2006; 26(30): 7933 - 7941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bereshpolova, C. R. Stoelzel, A. G. Gusev, T. Bezdudnaya, and H. A. Swadlow The impact of a corticotectal impulse on the awake superior colliculus. J. Neurosci., February 22, 2006; 26(8): 2250 - 2259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J Veredas, F. J Vico, and J.-M. Alonso Factors determining the precision of the correlated firing generated by a monosynaptic connection in the cat visual pathway J. Physiol., September 15, 2005; 567(3): 1057 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Pluto, N. L. Chiaia, R. W. Rhoades, and R. D. Lane Reducing Contralateral SI Activity Reveals Hindlimb Receptive Fields in the SI Forelimb-Stump Representation of Neonatally Amputated Rats J Neurophysiol, September 1, 2005; 94(3): 1727 - 1732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Alonso and H. A. Swadlow Thalamocortical Specificity and the Synthesis of Sensory Cortical Receptive Fields J Neurophysiol, July 1, 2005; 94(1): 26 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Z. Lauritzen and K. D. Miller Different Roles for Simple-Cell and Complex-Cell Inhibition in V1 J. Neurosci., November 12, 2003; 23(32): 10201 - 10213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Butovas and C. Schwarz Spatiotemporal Effects of Microstimulation in Rat Neocortex: A Parametric Study Using Multielectrode Recordings J Neurophysiol, November 1, 2003; 90(5): 3024 - 3039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Temereanca and D. J. Simons Local Field Potentials and the Encoding of Whisker Deflections by Population Firing Synchrony in Thalamic Barreloids J Neurophysiol, April 1, 2003; 89(4): 2137 - 2145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Nowak, R. Azouz, M. V. Sanchez-Vives, C. M. Gray, and D. A. McCormick Electrophysiological Classes of Cat Primary Visual Cortical Neurons In Vivo as Revealed by Quantitative Analyses J Neurophysiol, March 1, 2003; 89(3): 1541 - 1566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. N. Beloozerova, M. G. Sirota, and H. A. Swadlow Activity of Different Classes of Neurons of the Motor Cortex during Locomotion J. Neurosci., February 1, 2003; 23(3): 1087 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Swadlow Fast-spike Interneurons and Feedforward Inhibition in Awake Sensory Neocortex Cereb Cortex, January 1, 2003; 13(1): 25 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Pinto, J. A. Hartings, J. C. Brumberg, and D. J. Simons Cortical Damping: Analysis of Thalamocortical Response Transformations in Rodent Barrel Cortex Cereb Cortex, January 1, 2003; 13(1): 33 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Bruno and D. J. Simons Feedforward Mechanisms of Excitatory and Inhibitory Cortical Receptive Fields J. Neurosci., December 15, 2002; 22(24): 10966 - 10975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Constantinidis and P. S. Goldman-Rakic Correlated Discharges Among Putative Pyramidal Neurons and Interneurons in the Primate Prefrontal Cortex J Neurophysiol, December 1, 2002; 88(6): 3487 - 3497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Castro-Alamancos Role of Thalamocortical Sensory Suppression during Arousal: Focusing Sensory Inputs in Neocortex J. Neurosci., November 15, 2002; 22(22): 9651 - 9655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Beierlein and B. W. Connors Short-Term Dynamics of Thalamocortical and Intracortical Synapses Onto Layer 6 Neurons in Neocortex J Neurophysiol, October 1, 2002; 88(4): 1924 - 1932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Swadlow, A. G. Gusev, and T. Bezdudnaya Activation of a Cortical Column by a Thalamocortical Impulse J. Neurosci., September 1, 2002; 22(17): 7766 - 7773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Bair, J. R. Cavanaugh, M. A. Smith, and J. A. Movshon The Timing of Response Onset and Offset in Macaque Visual Neurons J. Neurosci., April 15, 2002; 22(8): 3189 - 3205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Miller, M. A. Escabi, H. L. Read, and C. E. Schreiner Spectrotemporal Receptive Fields in the Lemniscal Auditory Thalamus and Cortex J Neurophysiol, January 1, 2002; 87(1): 516 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Frank, E. N. Brown, and M. A. Wilson A Comparison of the Firing Properties of Putative Excitatory and Inhibitory Neurons From CA1 and the Entorhinal Cortex J Neurophysiol, October 1, 2001; 86(4): 2029 - 2040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Sosnik, S. Haidarliu, and E. Ahissar Temporal Frequency of Whisker Movement. I. Representations in Brain Stem and Thalamus J Neurophysiol, July 1, 2001; 86(1): 339 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ahissar, R. Sosnik, K. Bagdasarian, and S. Haidarliu Temporal Frequency of Whisker Movement. II. Laminar Organization of Cortical Representations J Neurophysiol, July 1, 2001; 86(1): 354 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Alonso, W. M. Usrey, and R. C. Reid Rules of Connectivity between Geniculate Cells and Simple Cells in Cat Primary Visual Cortex J. Neurosci., June 1, 2001; 21(11): 4002 - 4015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Jones, K. D. MacDonald, B. Choi, F. E. Dudek, and D. S. Barth Intracellular Correlates of Fast (>200 Hz) Electrical Oscillations in Rat Somatosensory Cortex J Neurophysiol, September 1, 2000; 84(3): 1505 - 1518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Hartings, S. Temereanca, and D. J. Simons High Responsiveness and Direction Sensitivity of Neurons in the Rat Thalamic Reticular Nucleus to Vibrissa Deflections J Neurophysiol, May 1, 2000; 83(5): 2791 - 2801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Swadlow and A. G. Gusev The Influence of Single VB Thalamocortical Impulses on Barrel Columns of Rabbit Somatosensory Cortex J Neurophysiol, May 1, 2000; 83(5): 2802 - 2813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Pinto, J. C. Brumberg, and D. J. Simons Circuit Dynamics and Coding Strategies in Rodent Somatosensory Cortex J Neurophysiol, March 1, 2000; 83(3): 1158 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Zhu and B. W. Connors Intrinsic Firing Patterns and Whisker-Evoked Synaptic Responses of Neurons in the Rat Barrel Cortex J Neurophysiol, March 1, 1999; 81(3): 1171 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Swadlow, I. N. Beloozerova, and M. G. Sirota Sharp, Local Synchrony Among Putative Feed-Forward Inhibitory Interneurons of Rabbit Somatosensory Cortex J Neurophysiol, February 1, 1998; 79(2): 567 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. McCasland and L. S. Hibbard GABAergic Neurons in Barrel Cortex Show Strong, Whisker-Dependent Metabolic Activation during Normal Behavior J. Neurosci., July 15, 1997; 17(14): 5509 - 5527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Gil and Y. Amitai Properties of Convergent Thalamocortical and Intracortical Synaptic Potentials in Single Neurons of Neocortex J. Neurosci., October 15, 1996; 16(20): 6567 - 6578. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
