JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 73: 2459-2469, 1995;
0022-3077/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xu, X.
Right arrow Articles by Karwoski, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, X.
Right arrow Articles by Karwoski, C.

Journal of Neurophysiology, Vol 73, Issue 6 2459-2469, Copyright © 1995 by APS

ARTICLES

Current source density analysis of the electroretinographic d wave of frog retina

X. Xu and C. Karwoski
Department of Psychology, University of Georgia, Athens 30602, USA.

1. Dark flashes were used to evoke spatiotemporal profiles of the d wave of the electroretinogram in frog retina. The current source density technique was used to compute the extracellular current sinks and sources underlying the d wave. 2. The largest d wave current was a sink at the outer plexiform layer (OPL sink) and a source at the inner plexiform layer (IPL source). Several properties of this sink/source, including its relative insensitivity to Ba2+, suggest that it arises from hyperpolarizing bipolar cells. 3. There was a slower IPL sink, along with a source at the inner limiting membrane (ILM source). Its properties, along with its sensitivity to Ba2+ and enhancement by picrotoxin, suggest it arises from the K+ spatial buffer currents of Muller cells. This IPL sink/ILM source underlies the M wave. 4. A small photoreceptor sink/source also contributes to the d wave. This is most significant during the very beginning of the d wave. 5. Our results indicate that in frog retina and at the stimulus conditions used in this paper, the d wave originates primarily and directly from the hyperpolarizing bipolar cells. Photoreceptors likely contribute a small amount, especially during the initial portion of the d wave. There is possibly a small Muller cell contribution.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
N. W. Khan, M. Kondo, K. T. Hiriyanna, J. A. Jamison, R. A. Bush, and P. A. Sieving
Primate Retinal Signaling Pathways: Suppressing ON-Pathway Activity in Monkey With Glutamate Analogues Mimics Human CSNB1-NYX Genetic Night Blindness
J Neurophysiol, January 1, 2005; 93(1): 481 - 492.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. A. Van Epps, C. M. Yim, J. B. Hurley, and S. E. Brockerhoff
Investigations of Photoreceptor Synaptic Transmission and Light Adaptation in the Zebrafish Visual Mutant nrc
Invest. Ophthalmol. Vis. Sci., March 1, 2001; 42(3): 868 - 874.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
G. B. Awatramani and M. M. Slaughter
Origin of Transient and Sustained Responses in Ganglion Cells of the Retina
J. Neurosci., September 15, 2000; 20(18): 7087 - 7095.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
B. Fortune, M. E. Schneck, and A. J. Adams
Multifocal Electroretinogram Delays Reveal Local Retinal Dysfunction in Early Diabetic Retinopathy
Invest. Ophthalmol. Vis. Sci., October 1, 1999; 40(11): 2638 - 2651.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online